Calling all TNs

Meadow

Yes loving the news Ally

Allydp

Thank you all so much!

Gramof2boys

Great news Ally!

JohnSmith

I've never posted in the TN section, but I was curious about something.

Cancer cells have a variety of receptors on them that fuel their growth. With hormone positive folks (like my wife), estrogen tends to be the major driver since they have estrogen receptors on the cells.

So, what drives the growth of TNBC? Essentially, what receptors exist on TN cancer cells that drive the growth?

just curious...

Allydp

JohnSmith - there's a lot of research going into this very question. There's some studies that suggest TN tumors possibly have androgen receptors or folate receptors or opioid receptors, but nothing concrete has been proven. I know a few women who's tumors started out hormone positive and morphed into TN, so who really knows. Hopefully they can zoom in on something concrete soon.

placid44

JohnSmith,

I've also read that at a molecular level,TNBC is similar to ovarian cancer...more similar to that than other breast cancers. Almost like an ovarian tumor that appears in the breast.

JohnSmith

Hmmm... if there's no obvious receptors that are driving TN cell growth, than there must be other mechanisms (that have nothing to do with receptors) fueling growth. But, if cell receptors are utilized, maybe there's numerous ones activated, yet each one is so subtle that they aren't significantly detectable / measurable. Perhaps the sum total of all of these subtle receptors add up enough to allow significant cell growth.

placid44

cancer cell growth can occur because something is fueling it or because nothing is available to inhibit the growth.

Honeytagh

Hi. Im a new member to this thread diaognosed with tnbc at 32 without any family history. I have had lumpectomy chemo and rads. Yet my oncologist has prescribed dipherline every three months for five years as he believes my periods should be shut down.Has anyone heard of it? Im really embarrassed and dont know what to do as my surgon who is a well known professor does not agree with my oncologist

Luvmydobies

Hi there Han, I've never heard of those injections you asked about for TN.

Coopdizzle

I don't know what to tell you. I had a hysterectomy because I'm BRCA1. I haven't heard of TN women getting any aftercare meds.

MomMom

Ally & Luv,  So, so happy for you both!!! Awesome!!

Shari, Thinking of you and hope your recovery is problem free.

Arlene, Sorry for your complication, may that be a blip that passes quickly.

Simple, Congrats on a great report!  Words we all love to hear.

Paula

 

slv58

Hi everyone, I'll have to go back and read the couple of pages I've missed but I can't concentrate for to long yet!

Ally I am so thrilled you got great results! You've brightened my day- shuffle shuffle shuffle (best I can do right now!)

Had horrible effects of morphine causing extreme nausea-given anti nausea that made me dizzy that made me nauseated! Managed to get off the morphine and am doing well with Tylenol. Had low oxygen levels which they are working on, thus I tire easily but forcing myself to walk. Still in hospital because of lung issues but may go home mon or tues. Wifi is sketchy here, so will try to read up bit by bit and watch the video! Hugs to everyone for seeing me through this with your love, prayers and positive energy! Love to all, nighty- night ;-)

Shari

Cocker_Spaniel

HanTagh my understanding of Diphereline (another name for it is (Triptorelin Embonate) is that its a medication used to treat prostate cancer by lowering testosterone in men.  It belongs to a group of medicines for the release of hormones and should not be taken by women. In some cases, although its not a cure,  it can help men with prostate cancer but in others it can increase the growth of cancer.    I'm 100% sure you don't have prostate cancer so I would be having a very long discussion with my oncologist before I would even consider taking this drug.   

John Smith it is universally known that the scientists do not know what is causing the TNBC cell growth.  It does not have any receptors. They have come up with so many different theories over the years such as androgen and folate  but as yet nothing has been found to inhibit the growth.   I do believe though that they are on the brink of discovering exactly what causes such an aggressive cancer and it is only a matter of time but of course we all want to know how much time.  It is reassuring to know that they are working on it at this very moment.     

Tobycc

Shari, we all know it is hard to rest in a hospital but know you are covered in prayer and warm in our pockets! Try and rest, one step at a time

Kath

Luvmydobies

Shari, I'm so sorry you're still in the hospital but am glad you checked in. Hang in there and just try to get some rest! Praying for you for comfort, speedy healing and rest. XOXO!!!

simplelife4real

Shari, thanks for the update. I'm sorry you have had so many complications. That sounds miserable! I hope they release you soon and you can get back home to your own bed (and your own internet). I'm glad you made it through the surgery okay. ((hugs)))

greenae

Shari

Good to hear from you! I hope you are feeling better and getting stronger. Sending Hugs and positive vibes...

love, arlene

anotherNYCGirl

Shari, - Feel better and go home SOON!!

Arlene, - Good to see you posting! How are you doing?

Hugs to all here!

greenae

Hi Another!

Feeling ok, still with some discomfort and the drain, but 0cc today. so hoping to lose it tomorrow. Starting chemo in a couple of weeks...looks like it will be TC, getting prelim labs Wednesday. Just still so tired...dumped the pain meds during the day...and going to try to quit at night, starting tonight. Afraid to read about Cytoxan and Taxotere, yet...don't want to have myself experiencing every SE before chemo even starts...lol How are you? Hope all is good!

love, arlene

eileenpg

Greenae= I did Taxotere and Cytoxan. You can do it!!! It is manageable.  I worked part time the entire time I was on chemo and continued to exercise.  3 1/2 months since my last chemo. Feeling better than ever. Glad your surgery went  well and you are done with that part.

MomMom

Arlene,  Chemo for many (and I was one of them!) is very doable.  You can see from my signature that I had it all - ACT.  I exercised every day through chemo (albeit at a slower pace) at age 67. My gym friends were a huge source of encouragement.  If you can manage some exercise, it will serve you well.  Thinking of you as you continue to recover from your surgery.

Shari, Prayers and healing thoughts your way as you continue to recover.  So sorry for the horrible SE's from the morphine. Huge hugs to you both.

Paula

 

greenae

Paula and Eileen

Thank you!! You both made my day! I really would like to give up the worrying and researching and just get through each day. Maybe spring coming, along with my chemo will help, as both of you just did. Muhwaaah!

arlene

Honeytagh

Though I m new to this thread and I dont know the members well I send my wish and prayers to Shari and all.

Luvmydobies

Arlene, great to hear from you! Hope you lose those drains tomorrow! You'll feel much better after that. I'm also one that wasn't bothered by chemo. Never once even felt sick, until I got CDiff but that was NOT from chemo. You'll be alright! HUGS!

Shellbeach7

I just wanted to tell you how much I enjoyed your video. . So lovely and fun for your children, thank you for sharing, you made it special, so real, yet lighthearted. I've just been diagnosed and also just joined this sight, this is all so new, but your video was so comforting and inspiring, along with all the posts I've read so far.

SA8PG

Continued prayers & hugs for Shari.

Ally & Luv so happy to hear your great news. Yippie!!!!

Arlene you can do this!!! I was 2 weeks post partum from delivering my son & really wore down when I staterd chemo. The Sancuso patch (for nauesea) was a life saver for me. I wore that on my upper arm day of and 7 days after chemo. Never got sick once. You got this!!! Hugs & prayers your way.

HanTagh & Shellbeach7 welcome to this wonderful support group. I'm sorry your here but know that this group is full of love & support for you. It has brought me much encouragement. :-)

Shellbeach7

Thank you so much for your kind message SA8PG. . I'm waiting to have some genetic testing done, from there decision will be made as to what type of surgery will be scheduled.

There is so much to learn and process, but I will say, for getting this kind of "bad news", it has been a such beautiful experience. Everyone I've encountered in the last two weeks has been so kind and helpful, from my Incredible nurse practitioner who found the lump during my annual, everyone at our local cancer center, to the posts from this particular discussion board (I haven't been on any others, I chose this particular board because it was for Triple Negative patients like myself.)

A Big Thank you again to you and to all the other bloggers for such inspiring, encouraging and amazing stories, kind and loving words and for making a newcomer feel so welcomed. .❤😊

Tobycc

The patch has worked wonders for me as well. I did the zofran during the taxotere round, until I had the reaction and switched to CMF. Now since I have been on that, been on the patch. Worked for 7 days for 5 tx, now I am switching out every 5-6 days.

You can do this, and welcome to the new ladies. I too am sorry you are here, but so glad you found us!

Kath

Meadow

Han and Shellbeach, welcome!