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  • Anonymous
    Anonymous Member Posts: 1,376
    edited November 2011

    Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells.

    Source

    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.

    Abstract

    PURPOSE:

    The existence of cancer stem cells (CSCs) in breast cancer has profound implications for cancer prevention. In this study, we evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, for its efficacy to inhibit breast CSCs and its potential mechanism.

    EXPERIMENTAL DESIGN:

    Aldefluor assay and mammosphere formation assay were used to evaluate the effect of sulforaphane on breast CSCs in vitro. A nonobese diabetic/severe combined immunodeficient xenograft model was used to determine whether sulforaphane could target breast CSCs in vivo, as assessed by Aldefluor assay, and tumor growth upon cell reimplantation in secondary mice. The potential mechanism was investigated using Western blotting analysis and beta-catenin reporter assay.

    RESULTS:

    Sulforaphane (1-5 micromol/L) decreased aldehyde dehydrogenase-positive cell population by 65% to 80% in human breast cancer cells (P < 0.01) and reduced the size and number of primary mammospheres by 8- to 125-fold and 45% to 75% (P < 0.01), respectively. Daily injection with 50 mg/kg sulforaphane for 2 weeks reduced aldehyde dehydrogenase-positive cells by >50% in nonobese diabetic/severe combined immunodeficient xenograft tumors (P = 0.003). Sulforaphane eliminated breast CSCs in vivo, thereby abrogating tumor growth after the reimplantation of primary tumor cells into the secondary mice (P < 0.01). Western blotting analysis and beta-catenin reporter assay showed that sulforaphane downregulated the Wnt/beta-catenin self-renewal pathway.

    CONCLUSIONS:

    Sulforaphane inhibits breast CSCs and downregulates the Wnt/beta-catenin self-renewal pathway. These findings support the use of sulforaphane for the chemoprevention of breast cancer stem cells and warrant further clinical evaluation.

  • CindyD
    CindyD Member Posts: 45
    edited November 2011

    Hi Ladies,

    I've been out of town for a couple of days and have a full day scheduled today. I will try to catch up tomorrow with all the awesome posts.

    Cindy

  • stage1
    stage1 Member Posts: 475
    edited November 2011

    I'm off to buy broccoli sprouts!  Thank you, Sharon!

  • Kaara
    Kaara Member Posts: 3,647
    edited November 2011

    I saw them in our grocery store.  They don't carry much organic produce, but I did see these.  How much would one have to eat to get the benefit?

  • B123
    B123 Member Posts: 730
    edited November 2011

    This is a great thread, I am so glad to come on to it and join you ladies! I have heard that Acai Berries play a very big role into prevention of reaccurance, it seems to be hard to find but I have had luck in the Brazilian stores.  I am not sure how well the Acai Berry vitamins and if they have the same effect?  I am also very interested in the Goji Berries as Princess has mentioned in this forum.  Does anyone know where those can be located?  If I dont have a juicer, is it possible to get the same effect of eating plenty of the greens mentioned, including watercress?  So many things to remember, it is so life altering, but of course so worth it! Thank you for sharing!

  • B123
    B123 Member Posts: 730
    edited November 2011

    Also, I have been told another fruit from South America that has a huge benefit to prevenative measures is soursop.  Hard to find but again, I find it in the Brazilian stores.  I have also seen Oprah talk about Acai berries and the benefits of it, with Dr. Oz.  I truley believe that the other countries live longer because they eat organic natural unprocessed foods grown in their backyards everyday. 

  • Anonymous
    Anonymous Member Posts: 1,376
    edited November 2011

    B123, acai berry cannot be dried as the goji can. But, from what I've read, acai seems to be most effective in a juice form though.  I buy dried goji berries at health food stores. The juice is extremely expensive.  

    If you don't have a juicer, you should definitely text  Santa and ask him for one. Juicing breaks down the cell walls of vegetables so that they are pre-digested. This means that all of the nutrients shoot straight into your system, instead of most going down the toilet.     

    This whole thread has lots of good info about vitamin d, enzymes, natural foods, iodine, glutathoine  magnesium, medicinal mushrooms, earthing, exercise, alcohol, alternative and integrative therapies etc.Take your time and go through it.  Also, jump in anytime and share info and ask questions.  The women here are really helpful and kind.  

    Sharon  

  • stage1
    stage1 Member Posts: 475
    edited November 2011

    My juicer is an old one, about 15 years ago I bought this Juiceman Jr.  I am wondering if the newer juicers are better.  Mine works, just seems like a lot is left in the machine.  Any comments, anyone??? Shall I buy a Vitamax??? I saw one at Costco for more than $300.

  • stage1
    stage1 Member Posts: 475
    edited November 2011

    I just went back top Cindy's post about the Vitamix, that is probably not what I need for juicing...

  • Anonymous
    Anonymous Member Posts: 1,376
    edited November 2011

    Stage 1, Breville is a really good brand. Take a look.  www.youtube.com/watch?v=lMJpWplyb_c It has great reviews on Amazon. I'm thinking of buying the vitamix because you can make yogurt, soups, nut milks etc with it.  

  • Kaara
    Kaara Member Posts: 3,647
    edited November 2011

    Stage 1:  You are right...Vitamix is not a juicer.  I have a Champion juicer which I have had for a long time....just reclaimed it from my DS.  My GD is buying me the greens attachment for it, she was so glad to hear that I am juicing.  She has been a vegetarian for several years and what a difference it made in her moods and life.  I'm still contemplating the Vitamix because of all the things princess said...it has a very high rating.  That Costco price sounds pretty good.  The ones I looked at were over $400.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited November 2011
    Kaara, there are enzymes. I can't remember which ones that are good to start taking before you have the surgery to help encapsulate the tumor. That's according to Dr. Burton Goldberg.  
  • stage1
    stage1 Member Posts: 475
    edited November 2011

    Thanks, Ladies, I am checking these out, my juicer works good and fast and it is strong, I am wondering if it is leaving too much behind, as when I clean it out seems like half the produce is left inside.  Is that usual with the Champion, also?  Or is it because I need an updated one?

  • stage1
    stage1 Member Posts: 475
    edited November 2011

    I am looking at the Breville, also.

  • stage1
    stage1 Member Posts: 475
    edited November 2011

    Okay, I watched the video on the Brelville, I think my Juiceman Jr. is very similar.  I also watched the video on the zuchinni bread made with the leftover pulp in the juicer.  Great idea.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited November 2011

    Zucchini bread sounds yummy. If you juice carrots, you can use the pulp to make raw carrot cake too.

  • Kaara
    Kaara Member Posts: 3,647
    edited November 2011

    My Champion juicer doesn't leave much pulp at all, and what is left is very dry.  The instructions said if the pulp is still wet to put it through the juicer again for maximum benefit, but I haven't had to do that as yet.  I'm telling you, this thing is a warhorse!  It survived 10 years with my DS who isn't known for his kind treatment of equipment, and it's still ticking.  Good idea to use pulp for other cooking.

    princess:  I remember hearing that about the enzymes as well...maybe I can find that in Suzanne Sommer's book "Knockout"...she interviewed Dr. Goldberg.

    We saw a great movie last night  "Food Matters".  Reinforces everything we've talked about on these threads...the importance of diet and supplementation in assisting the body in healing itself.  The use of vitamin infusion therapy was a big topic. 

  • Anonymous
    Anonymous Member Posts: 1,376
    edited November 2011
    Kaara, it's proteolytic enzymes. I'm not sure how much to take though.
  • Kaara
    Kaara Member Posts: 3,647
    edited November 2011

    Thanks princess!  Have a great weekend.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited November 2011
    Proteolytic enzymes are able to break down the walls of cancer cells and allow the immune system to handle them easily. Heavy meat eating may demand too many proteolytic enzymes to break down those complete proteins, which are needed to check the cancer cells normally floating around in our bodies.

    Heavy dosing of proteolytic enzyme supplements away from meals has succeeded with even terminal cancer patients. These enzymes, which also digest complete proteins, rip up cancer cell walls, leaving the cancer cells vulnerable to the immune system.


    Learn more: http://www.naturalnews.com/030116_enzymes_cancer.html#ixzz1eB9QihwP
  • Anonymous
    Anonymous Member Posts: 1,376
    edited November 2011

    Ladies, I just watched this  documentary. It's quite fascinating!

    Catching Cancer

    Can you catch cancer? Sixteen women in one workplace in Australia have all been diagnosed with breast cancer. Most are young, none have a family history of the disease and all the usual suspects - radiation, pollution, and chemical contaminations - have been investigated. Is it a co-incidence? Or could a virus be the hidden trigger? Catching Cancer investigates the latest research on the role of viruses and bacteria in certain cancers.

    Watch  http://youtu.be/XWJXqoaQU-k

  • Anonymous
    Anonymous Member Posts: 1,376
    edited November 2011

    Beautiful Minds

    Raised on a wildlife reserve in Alaska, 15-year old Garrett was interested in the dietary habits of their animals.

    After the tragic death of his mother, Garrett s father decided to home-school his son and assigned a book written by Dr. Max Gerson that proposes a direct link between diet and a cure for cancer.

    Fascinated, Garrett embarks on a cross-country road trip to investigate The Gerson Therapy. He meets with scientists, doctors and cancer survivors who reveal how it is in the best interest of the multi-billion dollar medical industry to dismiss the notion of alternative and natural cures.

    You can watch the full documentary on Youtube www.youtube.com/watch?v=QNoZSduLMuo  

    OR  Google  topdocumentaryfilms.com/beautiful-truth/. You can watch it for free there too.

  • B123
    B123 Member Posts: 730
    edited November 2011

    Princess, can you tell me where you can find the proteolytic supplements? I wonder why this is never told by the Oncs we see? The only thing they ever want to say is Chemo, they dont get to the route of the cause.  I have never used a juicer before, not sure how it works?  How many times do you need to drink from it a day?  Would it be for any mix of fruits/vegis?  Thank you ladies, this sight has been SO helpful!  I applause you all for doing so much research and finding all this information out.  I was on Tamox but stopped it 2 wks ago from the severe effects it had on me, still suffering through them, I will not do that again!

  • mommy4
    mommy4 Member Posts: 21
    edited November 2011

    My wonders also B123 you say u stopped tamox are u now on something else. I also am on oncs directions for tamox I do not like the effects. I need to find something else or nothing at all which would be my rather. Something natural instead.

  • Kaara
    Kaara Member Posts: 3,647
    edited November 2011

    I don't think you can just run out and indiscriminately start taking things that help to cure and prevent cancer.  Like anything else, there is a prescribed dose that works and too much may cause toxic side effects.  A good naturopathic doctor would be a valuable resource to have.  Suzanne Sommers book  "Knockout" has a number of them listed in the back in a special section.  They are broken down by state and cities.  This is how we found the doctor that my boyfriend is going to for his MS and who I will go to for my complementary cancer treatments.   Vitamin infusions are a very important part of healing, and only a doctor can set this up for you.

    Juicing requires that you buy a juicer that is preferably one that has an ability to get as much juice as possible, leaving very dry pulp.  You can google juicers and they come up in all shapes and sizes and prices, but cheap is not the best, because it will not juice up carrots and other hard veggies as well.  Most of these come with instructions on how to combine good veggies and fruits for optimal flavor.  Diet is pretty simple...veggies (raw) and protein in the morning,  (I usually do a salad with all kinds of veggies with a hard boiled egg, and a juiced drink),  raw veggies and protein for lunch, and either a carb (sweet potato or brown rice) and cooked veggies or protein and cooked veggies for dinner.  Cut out all white stuff...bread, pasta, white rice, desserts, etc.  You will start to feel more energy almost immediately once you have detoxed all of the processed foods out of your system.  This could take a while depending on how your eating habits have been over the years.  My boyfriend went from a highly acidic body to optimal alkaline in less than two months!

    The Gerson diet requires that you drink a lot of juice...up to 13 glasses a day I think they said.  Again, that needs some initial monitoring and set up to get the correct combinations for optimal healing.  It's quite a committment, but IMO it beats putting poison into you system.  I'm working into it slowly by changing my diet weekly to get more into the raw foods and juicing.  Once I hear what my final dx is and get treatment options, I will decide what I want to do, but regardless which way you go, diet and lifestyle play an important role.

    All the best to you in your quest for better health and quality of life. 

  • B123
    B123 Member Posts: 730
    edited November 2011

    Kaara, that IS quiet the commitment.. not an easy change.  But VERY well worth it!  I will try to eat salads and proteins but as for the juicing, I dont know that I can tolerate it right now give what the Tamox has done to me.  Thank you for the info.  As for the ND, you say there is some listed in the Somers book?  Did you see any for Boston??  THANK YOU!

    mommy4, I was on Tamox for 2 wks, had severe abdominal pains with severe diarrhea. They insisted it was a GI bug, NOT!  So 5 days later went back on but half the dose 10mg, and again 2 weeks later it was WORSE then before.  I am now 2 weeks OFF of it, and I am better but still having abdominal problems, diarrhea off/on (colitis symptoms) nausea, and I am afraid to eat/drink anything so I barely do now, which is scary because if I lose anymore weight I might disappear.  This is so not what I wanted.  It is very toxic and awful and I would do anything else then to take poison again!  I will start LUpron shots end of December instead of the meds.  I tried the Acai berries but that did a number on my stomach and went right through me, so I need to wait longer on those kinds of things.  Hopeing the GI specilaist will give me something tomorrow to fix this.

  • Kaara
    Kaara Member Posts: 3,647
    edited November 2011

    B123:  What a shame that you are going through this.  I hate to tell you this, but I watched this exact thing happen to my friend with lung cancer.  She got so sick she couldn't eat, but they kept feeding her the chemo anyway, and she died from malnutrition nine months later.  I just couldn't believe my eyes what happened to her, and she wouldn't tell them to STOP.  There just has to be a better way to combat cancer than poisioning our bodies.  Some people can handle it and some not.  You have to know your body and what its limits are.

    You might be surprised about the juice drinks...because they contain little or no pulp, they go right into your system, bypassing the digestive tract so they might be easier to absorb and give you the nutrients you need to get back to optimal health.  Try buying some organic carrot juice at the store that is already juiced (make sure it's pure) and see if you can tolerate it.

    I looked in my book and didn't see a dr. in Boston listed...only one in Lenox Ma.  If you google integrative doctors, or naturopathic doctors, Boston area, some will probably come up.

    In any event DO NOT go back on that stuff, at least until you have your digestive problem straightened out. 

  • stage1
    stage1 Member Posts: 475
    edited November 2011

    Sharon, I am wondering if I will be getting enough fiber in my system, if I am juicing most of my veggies and salad ingredients.  I am also trying to lose ten pounds to get to my BMI weight...any suggestions?  Any comments, anyone?  I am wondering, also, if the enzyme supplements will interfere with medications, ie..arimidex.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited November 2011

    Wow! Lots of questions here. But I'll do my best to answer them.

    Proteolytic enzymes are not difficult to find. Most health food stores should carry them. Enzymes are commonly included in alternative theatment protocols.   As I mentioned above, I do not know what dosage should be taken.( I imagine that it will be way more than what's  recommended on the bottle. ) If you are on medications, speak to your pharmacist about the foods and vitamins that may interact with your meds. I'm not on any meds so I can't really tell you for sure.  

    The reason your oncs have not told you about most of the information that you are learning here is because they don't go to the causes of  cancer or know very much about supplements and nutrition. Unlike  NDs,  oncs treat the cancer, not the person who has cancer. They only have chemo, rads, drugs and surgery in their toolboxes. NDs  look at what toxins you may have been exposed to; why your immune system failed you, what vitamins and minerals you are deficient in etc.  Their tests are also very different and comprehensive. The results allow them to tailor a regimen that is right for your body's needs.  

    IMO, the best thing to do is do your own research and ask lots  of questions.  Knowledge is power. There's lots of info on this thread to help you get started.  Then, shop around for a ND who specializes in oncology.  That way you'll be well prepared to ask him/her really smart questions.

    For those of you who do not elect to have chemotherapy, or for whom chemotherapy and/or Tamoxifen would appear to be a poor option, Kaara is right, there is a good list of clinics in the book, Knock Out.   Also, there are many alternative/integrative cancer clinics that help patients reverse cancer listed on this site  Directory of Clinics www.cancure.org/directory_clinics.htm.  

    Commonly used  alternative therapies  include, among others,  intravenous vitamin C and B17, metabolic therapy, insulin potentiated therapy and ozone therapy.  Again, do your research and understand how they work first.  Some are mentioned on this thread.

    As for juicing, I'll tell you what I do.  I drink green juice 1-2 times per day.  That's my medicine. Also, I eat fruits and vegatables with my meals, so I'm still getting enough fiber. You can use the pulp to make other dishes like soups, so it doesn't go to waste.

    When I do juice feasts to detox, I drink lots of green juice and some raw fruits and maybe a small salads at night. That's it for 3-10 days. No animal products or cooked foods are allowed. It's intense. But, I'm use to it now.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited November 2011
    Stage 1, as long as you are exercising and eatting healthy--mainly raw and lighty steamed veggies, fruits, seeds, nuts, fish and staying away from sugar, dairy, too much red meat, alcohol, starchy carbs and junk food, the extra 10lbs will melt off nicely. You don't have to "diet". Just make really good choices.

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