2014 San Antonio Breast Cancer Symposium

besa

http://www.sciencedaily.com/releases/2014/12/14121...

"Tamoxifen reduces breast cancer rates by nearly a third for 20 years"

besa

http://www.sciencedaily.com/releases/2014/12/14121...

"New drug combination for advanced breast cancer delays disease progression"

voraciousreader

http://www.marketwatch.com/story/radius-health-pre...

voraciousreader

http://www.prnewswire.com/news-releases/san-antoni...

voraciousreader

http://medicalxpress.com/news/2014-12-san-antonio-...

voraciousreader

http://www.businesswire.com/news/home/201412110051...

JohnSmith

Regarding the SOFT trial results, Medha Sutliff of the "Young Survival Coalition" posted this video earlier today.

Also, here's a slightly different spin (than the earlier posted article) regarding SOFT results:
Ovarian Suppression emerges as "Practice Changing" option for younger, premenopausal patients

cider8

The SOFT results are pretty neat. I wonder if I could have avoided a recurrence and new primary if I had ovarian suppression. No way I'm stopping Zoladex. Next injection is tomorrow. But I wonder how they will decide on Tamox vs AI? And Arimidex vs Aromasin? It's really weird reading the medical language, especially "toxicity." I'm miserable these days with the fatigue and aches and stiffness that I'm sure is from OS and AI. But I'm alive and NED...

I'm interested in (I think) a report about anesthesia related to increase of recurrence (as in, could it relate to my recurrence and new primary?). I'm not on top of things as most of you, so I appreciate the links and discussion

voraciousreader

cider.....here is a clinical trial with respect to anesthesia and recurrence

http://www.cancer.gov/clinicaltrials/search/view?c...

voraciousreader

http://journals.lww.com/anesthesia-analgesia/Abstr...

Cider...here is an interesting study

cider8

Androgen receptor target therapy sounds fascinating! It gets my heart pumping! What if that's a big missing treatment? People who think no one is working on a cure for cancer does not see all this research.

My RO from MDA was quoted in the rads articles. And my MO from MDA presented at the conference yesterday on circulating tumor cells. I love my cutting edge doctors! I do get bummed I never qualify for clinical trials. But I am sort of a funk right now. (Ok, way off the topic of this thread!

ETA: thanks for the links VR. I've never gotten any of my anesthesia reports to see what I had.

voraciousreader

cider...I wasn't aware of the anesthesia link...thanks for informing me! I haven't had general anesthesia since my diagnosis. Hope I won't need it any time soon! Almost had it a few weeks ago...but I was able to talk the anesthesiologist out of it! He said if I answered all of his questions correctly, I could avoid it! Now I'm glad that I pushed for a local!

geewhiz

Thanks for the anesthesia studies!!

This is why I push for keterolac during surgeries...for some reason it shows a slight reduction in recurrence. My first surgeon used it already anyway. My subsequent surgeries I had to battle a bit as the new surgeon said that there is a minor increased chance of bleeding with it. And like you Voracious - with my knee surgery last year I asked for a block and remained awake. Freaked my surgeon out a bit, but she was young and super cool. It was just a meniscus repair. The less drugs the better. Good grief I am falling apart from every end.

voraciousreader

http://mobile.reuters.com/article/idUSFWN0TW02I201...

Afinitor fails in advanced HER 2 POSITIVE BC

voraciousreader

http://www.thepharmaletter.com/article/domp-announ...

Triple negative

voraciousreader

https://www.bcm.edu/news/cancer-breast/study-targe...

HER 2 POSITIVE

voraciousreader

https://www.genomeweb.com/drug-discovery-developme...

Afinitor helped a subset....

voraciousreader

http://www.webmd.com/breast-cancer/news/20141212/l...

Low fat diet

voraciousreader

http://www.onclive.com/conference-coverage/SABCS-2...

voraciousreader

http://www.onclive.com/conference-coverage/SABCS-2...

High risk of developing breast cancer and Tamoxifen

Moderators

Hi all! See the NEW Breastcancer.org podcast, discussing much research presented at SABCS. We'll also be reporting on the stories with our Research News program, and will post the stories here!

2014 San Antonio Breast Cancer Symposium Research Highlights, December 12, 2014

In this Breastcancer.org podcast, Brian Wojciechowski, M.D., Breastcancer.org medical adviser, discusses some of the research that was presented at the 2014 San Antonio Breast Cancer Symposium. Listen to the podcast to hear Dr. Wojciechowski explain:

• results of a study that found that Aromasin plus ovarian suppression reduced recurrence risk better than tamoxifen plus ovarian suppression in women diagnosed with early-stage, hormone-receptor-positive disease
• research that underscored the long-term benefits of tamoxifen for reducing risk in women with a higher-than-average risk of breast cancer who've never been diagnosed
• a study showing that Faslodex worked better than Arimidex as a first treatment for women newly diagnosed with advanced-stage breast cancer
• research conducted in part by Breastcancer.org that shows that breastfeeding, even for a short time, reduces breast cancer risk more than previously thought
• why a low-fat diet improved survival in women diagnosed with hormone-receptor-negative breast cancer

Running time: 16:01

Listen now.

Moderators

Aromasin Plus Ovarian Suppression Reduces Recurrence Risk Better Than Tamoxifen Plus Ovarian Suppression in Premenopausal Women Who've Received Chemotherapy (with video)
December 11, 2014
Watch an interview with Prudence Francis, M.D., lead author of the SOFT study, which suggests that Aromasin plus ovarian suppression reduces the risk of recurrence more than tamoxifen plus ovarian suppression in premenopausal women diagnosed with early-stage hormone-receptor-positive breast cancer that's been treated with chemotherapy. Read more...

voraciousreader

Kay...When I was diagnosed, I was already on a low fat diet, by default, for 15 years, because of the DH's disorder! He is deficient in the enzyme that brakes down fatty acids that are needed to create energy...and I STILL got cancer! 😞

Dealing already with world class endocrinologists and dieticians due to the DH, following my own diagnosis, I asked if there were any dietary changes that I should make and they pretty much implied, Good Luck! They explained that the human body is quite elegant for most of us...and when bad things happen, correcting things, via diet, is not as simple as it seems....I already knew that going into the DH's battle...silly of me to think it would be any easier when it came to my own cancer...

voraciousreader

kay, tricky is what all of these studies are! I take exception to most of these studies that imply diet and nutrition! I recall when my gyno's wife was diagnosed with late stage ovarian cancer....quite ironic don't you think....her husband is a gyno and she got ovarian cancer.....he said to me that he just couldn't understand how his wife and I got cancer. He said he believed we were so "healthy" before our diagnoses....

I think studies like this make me feel worse because like her, I led such a "healthy lifestyle" before being diagnosed. I don't think there is anything more that I should of or could have done and that's what is so frustrating! I have a morbidly obese sister. The worst thing that has happened to her is she needed knee replacement due to her weight! Mom is approaching 90 and eats a fat laden diet to the point that watching her eat sometimes makes me physically ill! My kids once complained that her cooking made them sick! Surprise! She is doing FANTASTIC! Looks better than most women twenty years younger!

Kay....there is NOTHING and I do mean NOTHING in these types of studies that would convince me that they are meaningful.

BayouBabe

http://www.forbes.com/sites/elaineschattner/2014/1...

Fourminor

I was so swayed by Robert Lustig's very scientific argument that sugar is a toxin in Fat Chance, that I find it hard to accept that its fat. I mean this guy actually went over cell biology and metabolic pathways and shows that our cells are designed to run on glucose, and lactose, but not fructose, although fructose when consumed in whole fresh fruit is mitigated by the fiber. The population studies he cites about high blood pressure, diabetes, metabolic syndrome, and the rapid acceleration of obesity at the time that low fat diets were promoted to reduce heart disease--which took decades for people to question--I"m sold. I also know that after I had my son I had such a hard time losing weight that i went on the Zone Diet for two months which had two small servings of meat a day. I am not a big meat eater, but I was desperate, and the weight melted off me. IT was all veggies, whole grains, a little dairy and lean meat. Based on that I went back to eating some meat--not a lot though--mainly chicken a few times a week and red meat a few times a year.

Now i don't know what to do!! I'm wondering if I should continue to try to keep my sugar intake low, and maybe cut back on dairy and meat as much as possible?

besa

When it comes to all these diet studies I can't help but think of the 1973 Woody Allen movie "Sleeper" and be skeptical (and smile). In the movie the main character, who owned the "Happy Carrot" health food store in 1973, wakes up after being frozen for 200 years and learns there was a whole new and different slew of popular "healthy" foods.

I do feel keeping a healthy weight is important but the rest of it -- exactly what we should be eating, I want to see more data and more studies before I become a believer :-)

rozem

just wanted to report back on my MO appointment in regards to SOFT results.  She said the only thing they don't know is if the benefit in OS+AI is the same if given years after treatment.  The women in the study all started in one of the arms within 8 months of finishing chemo.  I am over 3 years out.  She said that we can infer that it would still be beneficial for 2 reasons;  we know that er positive cancers can have late reccurances and we know that 10 years of hormone therapy has an advantage over 5.  So for  all these reasons plus i am considered high risk she is recommending I continue with the shots and switch to an AI

PoohBear-61

Rozem ...that's sounds very logical to me ....In my case however my MO agreed with me on my decision to stop the shots following the results of the Soft trial.

Ive been on them for 18 months and I am 48 years old so likely in menopause for good ( but you never know ) ....

Question is where do you exactly draw the line between the high risk and the low risk . I am Grade 2 and onco score of 18.

I am comfortable with the fact that I completed 18 months of these shots but am very happy to be stopping them as well .

rozem

poohbear - high risk in the study was defined as needing chemo - since it looks like you did not you would be in the low risk group (as defined by the study) I would have made the same decision as you !