INSOMNIACS place to talk in the wee hours

sas-schatzi

We all know I'm crazy and I love you all for accepting that, I wrote this to another member on a different thread today, But you each may benefit.

member name deleted, maybe this will help your study. Most of the bodies systems(7) have a "negative feedback mechanism" That allows the system to check if it's working.  Say the control is A. A sends a message to BCD to do something. EFG senses whether BCD are doing their job. E, F, G all sense something different. They independently send messages back to A. A decides what to do. If B,C, or D aren't performing right A sends out another message. A >>>BCD>>>EFG>>>A>>>BCD>>>EFG>>>A>>>etc.  It all happens rapidly and continuously. Until something interferes.

"blood vessel dilation which leads to collapse of blood pressure...." " the vasodilation causes all the blood to pool to the extremeties "  First a description of the vascular circuit>>>heart>>Aorta(artery, slang Big Red) >>branching arteries>>arteriole>>capillary>>venule>>vien>>Vena Cava(vein, big Blue)>>Right heart>then lung circuit>then left heart.

The arteriole is responsible for constricting or relaxing which will increase or decrease  the pressure. Analogous to a garden hose with thingy on the end that you turn to change flow. Lol can't think of word.  When the arteriole doesn't work right then pressure changes can cause problems. If it constricts without responding to A's messages to relax, it results in too much tension in the line. i.e hypertension. Conversely, if the arteriole relaxes too much, there's too little tension in the line i.e. hypotension

In the case of the vascular system ---hypertension= high blood pressure, hypotension= low blood pressure. The arteriole is responsible for the changes. The ANS is responsible for changing the tension on the arteriole.

There is a pressure gradient in the vascular circuit. The arterial pressure is higher then the venus pressure. If the arteriole malfunctions and dilates the pressure within the capillary changes. This allows leakage of fluid from the capillary into the space outside the capillary. This fluid can flood the space outside the vascular circuit.  This happens in certain conditions i.e ANS dysfunction; Septic shock; Drugs that are meant to lower BP, but are working beyond what they are meant to do, infection, immune response

 If the pressure in the venus side changes by becoming to high, then it can reverse the flow by changing the pressure in the capillary . The capillary can't withstand the pressure and the fluid floods out into the space outside the vascular system.

Increased capillary permeability is the official wording. Causes>>changes in either pressure gradient from the arterial side or venous side. Changes caused by drugs. Changes caused by chemicals either internal, or external.

Flooding from the capillary can occur b/c of two different reasons. Either the arteriole failed/changed, or the venous system pressure was too great and back flowed.

Work to understand why the arteriole fails

What drugs are you on.

When edema occurs in the lower  extrmeties or anywhere, it creates a logjam. When the logjam occurs nothing flows right. Other structures are compressed because there too much pressure on them from the extra fluid.

A river logjam is an excellent analogy. Logs pile up the river stops flowing. The river banks overflow. What is around the river is covered. Say there was a pumping station that usually filtered the water from the river to be taken and cleaned to be dumped back into the river. The pumping station can't work right. It no longer is filtering the water from the river.

The logjam creates the flooded area, the pumping station can't get the gunk out of the water. It all is a mess. All this stuff just stagnates. Things start to grow.  The growing stuff affects the things around it.

The bodies usual protective mechanism is the lowly lymph system. The reason I say lowly lymph system is people in general don't know about the lymph system. The high and mighty nervous and cardiovascular system, even grade schooler's can talk about. But the lowly lymph system is ignored until something goes wrong.

The lymph system is analogous to the filtering pump station in the logjam example. The lymph system filters i.e. cleans the area around the cells, picks up the garbage thrown out by the cells, moves it to the transport system i.e. lymph network. The lymph fluid is taken to the lymph nodes which further cleans up the garbage. The fluid then continues from the lymph node and is transported to the thoracic duct where it's dumped back into the vascular system.

With edema, the lymph pathways can be compressed. It can't pick up the waste products that the cells throw out, and carry these waste products away. Those waste products can cause multiple problems, infection-cellulitus, rash associated with bodies immune response to stuff that's irritating cells.--release of histamine which causes an itch.

This is an area to study. --"what is the bodies response when edema occurs". Hope some of this helps

 

sas-schatzi

Okay as usual to much to read, but I love you all and may be this will help a bit

Ziggy every time I write, I have you, DS, and VoraciousReader in my head(VR)----besides all the stuff that's up there-----the three off you are making it better----but crowded

sas-schatzi

I am such  a biatch, this is a post on 2D6, a repost from what I wrote on the ASCO site. _Oh such a troublemaker, but I do love Paintball therapy

May  3, 2014 12:55AM, edited  May  3, 2014 01:47AM    by sas-schatzi

Just posted the following on the ASCO thread announcing new guidelines . I will bring the link to the topic back here

http://www.cancernetwork.com/survivorship/asco-gui...

If you are going to recommend a drug such as Duloxetine, then you are obligated to make sure the patients body can metabolize it. Duloxetine is primarily metabolized by CYP2D6 and CYP1A2.. You have not been known to support CYP testing in the past. Yet, you support targeted therapy or targeted molecular therapy for use and development of cancer therapies.

Why you don't support the one, and support the other is a mystery.

I coined the phrase many years ago Paintball Drug Therapy and Paintball therapy. It is the antithesis of Targeted Drug Therapy or Targeted therapy

Providing the NCI definition of Targeted therapy first, and then defining Paintball therapy

The term Targeted  therapy which is defined by NCI  as: A type of treatment that uses drugs or other substances to identify and attack specific types of cancer cells with less harm to normal cells. Some targeted therapies block the action of certain enzymes, proteins, or other molecules involved in the growth and spread of cancer cells.

Conversely, Paintball therapy is a type of treatment that uses drugs or other substances that are given as a general treatment without knowing if a patients individual genetic metabolism can allow the treatment to be successful i.e when a paintball is thrown how it splatters is unknown. A portion of the paintball may hit it's target, thus effective by chance. The splatter of the paintball is unknown. The effects, thus, may be harmful ranging from mild to major. Also, the Paintball approach to therapies may entirely miss the target or be substantially limited because the ability to metabolize is absent or limited.

How can you justify the support of targeted therapy for some drugs and use the paintball approach for other drugs.

If Paintball therapy  or Paintball drug therapy enters the lexicon. I certainly would like to be credited with it's origin. 

 

Blessings2011

Jwoo - "amazing" being the active word here..... NOTHING was amazing. LOTS of old-lady stuff, except for one burnt-orange knit tracksuit that we can't imagine she ever wore. The rest is like tons of polyester pants and pilly sweaters, and a gazillion sweatshirts with cookies, cookie cutters,and gingerbread men that family members kept giving her. I also think she has at least 40 nylon camisoles....

~ ~ ~ 

Sassypants - soooo sorry about the vertigo. I have BPPV, Debarquement Syndrome, Migraine-Associated vertigo, and an visual-oculomotor processing defect on the left side of my brain. There was a time when I couldn't walk a straight line, as I couldn't tell which way the floor was tilting. I used a cane most days, and a wheelchair on my worst. Interestingly, over the years, I got my symptoms under control. However, taking Femara for the past six months, I've had two exciting dizzy spells, like I'm trying to do cartwheels standing up, just crashing into furniture everywhere I go. I did learn that Valium happens to be an effective vestibular suppressant for many types of vertigo.

~ ~ ~ 

Smaarty - Hungry? USE MORE WATER! Add more water to your soup powder and blend in a blender it til it's frothy, then heat it up slowly in the microwave. (Instructions say you can't do this, but I've done it for years.) Also, add 2 cups of water and 1/2 a cup of ice to your powdered shakes and blend them in a blender til frothy.... this doubles or triples the volume. No more hunger! And use that Torani SF syrup... very "desserty" taste....

~ ~ ~ 

Today was a "fake it til you make it" kinda day. SET MY ALARM , got up, took a shower, washed my hair, got dressed, put on makeup, went to see my Oncological therapist, had a lovely 2 hour lunch with a dear friend, went back to the hospital to deliver the quilts to Oncology patients, and to Optometry for DH to pick out new glasses. So I looked and acted like a normal person. If I can just manage to do that every day..... whoopeee!

All for now, Owlettes.... Nighty night!!!

sas-schatzi

Blessings what you accomplished today, puts me in bed. The problem may be another doc appointment tomorrow. I've reached the stage --PCP (by aletter written by me)---define blood work needed for next year with cpt codes, define need for scans with cpt codes. Nothing will be done outside these parameters per patients requests.

DBF awake Maybe BBL

camillegal

All right stop the snake stuff, LOL

Sas I read every word and understood about 27 words, the easy ones. Whoa is this stuff in u'r head and u get it all? OMG u'r a genius

All I ever heard  from my Dad was the human body is like a cars engine, u have to tune it up and take care of it--if one thing isn't working then the whole engines in trouble. hahaha That's why I don't understand all the things u say, my brain takes simplicity well. But I love how u explain things for all of us to get something out of it--OK Ziggy start interpreting it.
I had a wonderful nite with my little man, we talk about so much and he's so interesting he really makes me think with our conversations. And funny enough to make me laugh.

OH BTW how did we start Phylotrouble's police ankle bracelet and she was being watched by the police all th time. I remember when she came and introduced herself and all of a sudden we called her every name under the sun and teased the hell out of her and she threw it right back and just had fun with it.

susan3

sas..need to read that again in the am. To much for brain to handle at the end of the day. Thanks for all the info

!blessings..happy you had a great day

Blonde..hope you r doing ok with roids

Duchy..hope your tummy held up with all those cashews

sas..how's the vertigo

Cami..itching better I hope

Have a great Saturday everyone

camillegal

Susan u are brilliant---when I posted I really forgot almost everything I read but Sas's stuff and some parts I did read 2x, but still ?????? and yet u remembered everything I was going to say--So now I'm saying Ditto--Thank you Susan

susan3

cami...and that's what friends are for....do u want me to sing it to you...lol

Sleep well

camillegal

sas-schatzi

sorry folks too much di sarrno

mostlymom

for our bb....

susan3

wow beautiful.....thanks for starting off my morn with a smile mm

Teka

Owlettes, last night able to sleep with the bedroom window open!

Chevyboy

Morning gals!  Okay I'm back 2 pages, and taking it from there!  I'm still laughing at ole'what'shernameLilshit, talking about Phylli! She said...

"Phillywhoiscrazyasbatshit had a psyche eval and passed?"  Ha, ha!

See, it was so long ago, we may have skipped over our own evaluation we gave her, about her being in the "big-house" and that's why she had to wear that ankle monitor!  See, SHE said it first, and we took it from there!  SHE is the crazyierthanthou person around here!  

It might have to stem from her standing on her porch with a paint-ball gun, and shooting the neighborhood kids with it!    I think she mentioned swarms of the local gendarmes.. (police) converging on her house, and taking her away to be locked up and be best friends with "BIG ALICE" !

OH GOOD LORD NO!  NOT Big Alice!  She was the bully of the yard, and took kindly to our shy Pnyllidink!  So there you have it....  Save this for further reference...

She has been rather tight-lipped about the whole thing lately, but I'm SURE she would elaborate if anyone happened to comment?

FBB!  You doin' okay?  And you think Ziggy, I mean Lilshit is "normal"??

And so Nettie!  Don't go gettin' normal on us here!  We tend to just brush-off anything that has to do with "normal!"  Sorry about the pain in your arms!  And so why did you have to go and get "Tennis Elbow"?  I would change sports if I were you!   Maybe.... oh wait.... don't try bowling.... Maybe drinking?  Is that a sport?   No, not even "curling."

Sass, I STILL don't get "gist!"  You said...

Cami it's all the Gists' with their own body parts, not paying attention to what the other Gist' are doing.   WTH???  How's anyone supposed to know what is going on, with you speaking in code like that? 

I KNOW about Don Keehoteeee!   He was insane?  Too?   I don't know nothin' about "windmills"....  just water-falls!  Okay, now try putting THOSE two analogies together, sassy-pants!

Ha, ha!  GGHOLE !  I love that you have flower beds!  I'm going out to move some of my "stuff" around today!   BTW.... A worm is not a snake.  Just thought I would throw that in....   YOU are modeling?  WHAT?  Did you say a table decoration?  Take pictures! 

Uh-on.... Sass is dizzier than usual!  Vertigo, she says!  Damn, I hate when that happens!  I mean seriously...  It's stuff we take... I think!

Now I'll go back, and find some more to comment on... 

Chevyboy

The only way I can do this, is by going to where I left off, then typing my comments like in an email, then highlight, copy and paste to HERE, so I can post it, without fear of it going into the twi-light zone!

PHYLLIthoughtitwasarocketparty!  SEE?  Who was it questioning the thinking in her with her ankle bracelet?   She's even talking about glowing sticks and goals/holes  for SOMEthing.... Maybe it's her OWN party....?

And you are causing turmoil with your  Medical staff-stuff???  Good Lord Phylli!  You are going to wind up in trouble aGAIN!

She made fun of Sass....  I say that quietly....Ha!  I can just see her laying down in the middle of a grocery store! 

Okay.... we got lots of grass/weed/pot/MJ-plants around here!  Heard it's very profitable... You might look into that...  then you would REALLY have an excuse to be locked up!  

WREN!  Dang girl!  YOU are going to get in trouble TOO!  Shooting rockets off all over the place!  Oh, it's your SON?  SURE it is! 

Oh Phylli.... A "pocket-rocket!"  Thought I missed that one, right?

Cammi woke up...  Oh wait, it says 17 hours ago...   Yes... they let Phylli out on a pass...  But she still has that lumbering bracelet... 

Morning Smarty!  You are just making that bra stuff up, right?   Can you at least post a picture of what you are "doing?"   And you've lost 12 pounds!  Smart-ass!  Wish I could!  

Susan!  LOVE your pictures!   You are very creative!  I see an old coal-bucket in one!   And a tomato cage?  I am growing them too, if it ever decides to be Spring/Summer! 

LilDutchess just ate "3.5" servings of cashews?  That's about 1/10th of what the rest of us eat...   I LOVE them, so I don't buy them....  same with Pistachio's! 

Hello yourself Blondie!  Hope you are doing good...  You mean chemo?  Damn!  We love you!  Come back soon!

No Spookers!  That was her own "find"!  But my Brother would have had that same thought....  Sass and my Brother's minds are just alike... Drives me nuts! 

Yes... Susan!  He is a lovely boy, that snake of yours!  I forgot his name....   Nice set-up, for that terrarium!   Do you have a heated mat, or rock or something so he won't get the chills?

Okay.... I'll answer more later!  I totally GET what you are talking about Sass!  I'll BBL!  xoxoxo

Chevyboy

Oh wait!  I just found a picture of Lilshit! 

ziggypop

thanks, chevy,geez what a way to wake up. and who BUYS things for snakes - a heated bed for a snake, do you have a college fund going for your pet mosquitoes, too?

Where's teka ..     i need coffee bad. Grouchy me.

camillegal

Good Morning Ladies---(well except a few) the pole dancer, the ankle bracelet. altho they're female--not ladies oh whatever I'm talking about I don't know.

I'm in the middle of thinking so it's not easy to write a post. My thoughts are deep so it' difficult to share right now.

Blondie I hope u have a good week-end , I worry abut u, I can't understand why everything isn't figured out. Or did I miss something.

I hope Sas is resting now--Chevy did u really understand it all? geeze I was in a confused state (as usual) but more so--Well I understood "GIST" That was my term Missy, u just don't pay attention to anything I say cuz u don't want to. And I remember more about Pylobrat as I was reading what u wrote--it was so silly and yet it stuck.

OK here's my deep thought--It's about food-  Tomorrow I'm going to dinner and it will be everything Homemade, even the wine and cannolies, all Italian food what the Eff do I bring. See this is deep thinking and forget homemade--I don't do that anymore--really---See the kinds of problems I face, just spinning my wheels. I guess I'm on my own with this--it doesn't quify as a medical emergency.

ziggypop

That picture of me was from like ten years ago, chevster, obviously my outfit is going to be out of style now. I am ALWAYS up with the current fashions, so stop giving peoples the wrong impression. 

blondiex46

Nope Cammie didnt miss anything, they still dont know why I can't bresthe.

Is that a pix of the firecracker.?

susan3

blonde..hope they figure it out soon

I am lost with the ankle bracelet

Chevy. Of course he has a heated pad. He gets baths also. Got to be quick when he is done. Comes flying out of the water. But I have good hand eye coordination to catch him mid air. I am sure all you other ladies are happy to hear that story..lol

Ziggy...no pet mosquitoes. Now that would be just crazy

Back to work..break is over see ya

FierceBluebird

good morning. I'm pretty drained physically and emotionally, but thank you everyone for positive comments. Keeping up with reading, just not posting much. MostlyMom I loved the blue bird photo! It's an indigo bunting and I love them. We rarely get them here. What a beautiful photo! 

Sas, thanks for the PMs. You know I love ya.

Jwoo, love the avatar and your photos. 

Wren, we used to do model rockets too. No pocket rockets. You just look silly on those.

Zigster, you can't fool us. We know that's your incognito outfit to keep the paparazzi at bay.

Blessings & smaarty, if your talking about heating a diet drink/ powder be sure there is no aspartame in it. Aspartame turns to formaldehyde when heated. The reason diet sodas can't be left in hot cars. (Chemistry background)

And the vote is in. No snakes in doghouse. BlueBirds don't like them. 

camillegal

FBB post whenever u feel like it, we look forward to it--we just want u to be better---U sure as hell have a great attitude---much admired by all--Chevy can always put a smile on our faces.

And yes that is Ziggy in that picture I was there when it was taken, but she didn't see me, oh it was a few yrs ago but imagine what she looks like now, That was very flattering for her.

Susan do u know how funny u are???

Chevy I took that recipe for the peach stuff and I'm going to make that tomorrow easy, peasy--just thow everything together and that sounds good too.

Anonymous

smaarthing - Chevy and camm's answers are about as concise as you get about the ankle bracelet. They know the most because .....well just because.   Except that it really started out as an ankle monitor and one of them said it first.  Now I just pretend to decorate it and try to get a wi-fi signal from it. 

sassy - thanks for the explanation of the lymph stuff.  I got it!  I can't repeat it back but I know that the nodes dump stuff in the thoractic duct! Then it starts all over again.  The rest I would have to show you on a map.  And yes, I know you explained it to me before.  That's why I get it now!

susan - holy crap!  you catch a snake in mid-air???  That must be his favorite part of the bath.  haha, I made that up.  I have NO idea what snakes think about baths.  I only ever held one snake and that was during a snake demo.  Even then I had to make the ranger take it back when it started to go down the front of my blouse.  Freaked me right out.  I also held a baby alligator on the swamp tour that I took last month.  See?  I'm pretty brave and amazing. bahahahahahhahahaha.  Okay, maybe not.

Okay, I'm off to shower and try to smell as good as cammi. Then maybe do something productive....or just take a nap!

Phyllopian

 

 

 

Teka

I am going to finish out the weekend being lazy!

dutchiris

Good morning!  Peach stuff?  What peach stuff?  And Ziggy's picture....too funny.

It's always good to hear from you bluebird.  I hope you get some energy back soon.  Until then just get some rest.

Someone got Sas ruled up.  Is she being censored?  Really?

ziggypop

cami - I am just as lovely today as I was the day that photo was taken. 

my blue-balled friends: 

ziggypop

FBB- Still right in your pocket, 'cause you are the only one here that's nice to me. 

Sassypants- what did you DO!? You know what, I bet it's about that 'colorado' thing. Or it's about that rolling on the grocery store floor thing. Or maybe it's about that incident when phillywhogetspeopleintroubleallthetime and spookie's mom were there. I bet that's it. Get BETTER, we just can't have you being an all falling down radioactive girl all the time. The world needs you. You have to be better and feel GOOD. Understand, Quixote? 

ziggypop

Susan... I just don't know what to say about that snake flying in the air thing, what kind of woman are you? Do you do things like eat fire ants for 'fun', too?