"overall survival data from MONALEESA-2, breaking the 5-year mOS barrier for patients with metastatic HR+ breast cancer"

https://t.co/L5xeOZADVf

Treatment and Survivorship Interventions to Prevent Poor Body Image Outcomes in Breast Cancer Survivors

https://www.dovepress.com/treatment-and-survivorship-interventions-to-prevent-poor-body-image-ou-peer-reviewed-fulltext-article-BCTT

This might have already been posted, but I read it in detail yesterday. I think it's crucial that the BC medical community really spends time realizing that taking care of the whole person overrides what I still have seen as the knee jerk reaction to just annihilate the cancer with secondary regard to the aftermath of a woman who must live with decisions that can be made without us being prepared with the right questions or coming to an agreement with the best possible treatment.

Here are the major sections:

We Shared Decision-Making

Local Therapy De-Escalation

Axillary Downstaging

Radiation

Systemic Therapy

Lymphedema Risk Mitigation

Preventing and Managing Weight Gain During Treatment

Prehabilitation

Addressing Menopausal and Sexual Sequelae of Treatment

Psychological Interventions During Treatment

I feel strongly that these subjects need to be incorporated into the care of every newly diagnosed BC patient. I've gotten so much of this support and preparation from being here, but not everyone knows about options until they have made permanent decisions with what still seems to be a traditional approach that is a decade behind current best practices. As a person living in a city without a major breast care integrated care system, I still prefer to piece the right solution for me into what we have here. I may still end up traveling. But knowing that treating my cancer has options that require shared decisions is both empowering and unnerving for me. My BCS is in line with my approach, but for now, we may lack oncoplastic expertise that can keep be here.

Research done in Montreal could lead to treatment for [TNBC]

[Using CRISPR to knock out genes systematically, researchers identified two signalling pathways or gene networks of significance in TNBC.]

"One of them was an oncogenic pathway. Those are genes that normally promote cell proliferation on tumours and this one was hyperactivated in those breast cancer patients," Lebrun said.

The second group of genes, which normally act as tumour suppressors by preventing cells to multiply, were found to be inactive or asleep.

This combination, Lebrun believes, could explain why TNBC tumours are so "aggressive and metastatic."

Understanding which genetic mechanisms were involved allowed the team to then uncover existing drugs that targeted those networks.

One of the drugs they tested, Verteporfin, surprisingly had nothing to do with cancer.

"It's actually a drug that is used for disease of the degeneration of the retina. It's an eye disease," Lebrun said... In all, the team evaluated around 10 different drugs, with Verteporfin being one of two standouts... Individually, each [of those two] drug[s] had around a 20 per cent decrease in tumour growth... "But [together] we got something more like 80 per cent," he said. "That's what we call a synergistic effect."

Efforts have been underway since the summer to get Phase 1 clinical trials off the ground... [but] Lebrun said he couldn't give a timeline of when the trial would start and when patients could begin enrolling.

https://globalnews.ca/news/8702026/montreal-mcgill...

Lumpie, I was quite surprised to see that article, too! I wondered if it had anything to do with vitamin D, but that doesn't seem to be what they are thinking.

Norcals, thanks for the nod! Lumpie has led the way but I'm always interested to see what all the other posters have uncovered.

timing of chemo - as in morning or afternoon- may affect outcomes

"patients who received most treatments after noon required fewer dose reductions and were less likely to stop treatment.

In addition, recurrence rates were highest among patients who received at least 70% of treatments before noon."

https://www.cancertherapyadvisor.com/home/news/con...

test

Interesting in-animal study for cyclophosphamide+CSF1R-inhibitor in mTNBC. Some macrophages inhibition mechanisms... Hope such things come into clinical trials sooner than later: https://scienmag.com/a-promising-combination-thera...

Saulius

Dear Homemom, Cliff Notes for Dummies would be useful for me too:)D I also sometimes feel they write these articles only for a few selected people - nothing has changed since times of Socrates:)

Saulius

The most detailed photograph of a cell inner: https://angstrom3d.com/cst-molecular-landscapes

Man... how complicated life really is:/

Saulius

I’m wondering if anyone has an article or info on the efficacy of full axillary node removal vs radiation of nodes after a positive frozen section of the Sentinal node in surgery, but specifically for those with tumors over 5cm treated with neoadjuvent chemo. I can’t find info on this subset, most articles talk about small tumors and/or don’t mention neoadjuvent chemo.

Thanks in advance

Researchers reveal a possible biological mechanism connecting breast cancer and type 2 diabetes

https://www.news-medical.net/news/20220530/Researc...