CD47 Research at Stanford

That was written in July 2013 and much more has been elucidated since then. The emergence of numerous players, each creating their own Anti-CD47 approach, will ensure that one of them, if not all, will be successful. Like the author wrote, most believe that Anti-CD47 will be best in "combination therapy" settings. As a monotherapy (single agent), it probably won't be a smashing success, but who knows? We'll find out that answer within the next 6-9 months. As we all know, the purpose of the Phase 1 trials is to determine safety and the proper dosage. Anything beyond that is 'icing on the cake'.

Here's a great article released today about Toronto-based Trillium Therapeutics and their Anti-CD47 mAb. It's written by a PhD post-doc researcher who works in cancer research.
"Trillium Therapeutics: A pure-play on CD47 as an immuno-oncology target"

Also, there's a Facebook group called: "People for CD47 Cancer Cure" which discusses many of these concepts and provides updates on the clinical trials. Feel free to join the group and ask questions. The admin, a guy named Milan, is quite helpful at answering questions.

ML,
I'm not familiar with the petition issue. Perhaps a new thread could be started to discuss this?

Now, in terms of the high-dose chemo with purified stem cell therapy.
There's no question that the late 1990's phase I/II breast cancer clinical trial of High-Dose Chemo with rescue by autologous mobilized peripheral blood (MPB) is intriguing.
I think this might be the original 1996 trial link from clinicaltrials.gov
This 2012 Abstract discusses the trial results. Updates to this trial have also been discussed in Dr. Weissman's presentations, such as this more recent UCLA video from June 2015: "Why Aren't We Translating Discoveries When We Can? Some Case Studies" (~9 minutes in)

I'm told that larger RCT's were done and failed. I never researched those trials and have no other details though.

I'm also told the biggest issue with this approach is two words: "Werner Bezwoda". He's the South African stem cell scientist who fraudulently falsified his breast cancer purified stem cell research during the 1990's. He was fired in March 2000. Here's the wiki on the history.
It was such a scandal that it destroyed any chance that this therapy would be used by the current generation of oncologists. Here's an editorial written in 2000, shortly after the scandal was revealed, which discusses why this hurt the breast cancer community.
"Why Big Lies Matter: Lessons From the Bezwoda Affair"

It appears your video of Stage 4 Stanford survivor, E. Perez, is from January 2012.
I'd suggest emailing Dr. Judith Shizuru at Stanford (jshizuru@stanford) and ask if, and when, these trials will be re-launched.
I do think this is a topic that warrants a discussion, but it would be wise to start a new thread, since this has little to do with the ongoing CD47 effort.

News was just published (here and here) that Oxford University, in association with the Stanford Institute for Stem Cell Biology and Regenerative Medicine, has begun a Phase 1 Clinical Trial of the Anti-CD47 therapy against Acute Myeloid Leukemia (AML).

Here's a new 4 minute easy to understand video on CD47, with focus on breast cancer, here.

@Cure-ious. I'm not qualified to answer your questions. There's a Ovarian cancer thread on the inspire.com forum discussing CD47. There are a number of highly educated and informed patients/caretakers that might be able to answer your questions.
Thread is here.

This is good news.
Stanford has been very quiet about the CD47 trials. This one minute video, released today, here, is the first clinical update I've seen. It comes from Stanford's Dr. Krampitz who has been involved in pancreatic cancer & CD47 since the pre-clinical days.
It's not the greatest video (in terms of presentation), but the message is clear.
Safety is good. No adverse effects among patients.

I'm starting a clinical trial at Stanford with another drug next week so I am going to try to remember to ask the clinical onc about CD47. Thanks for keeping us updated. I am following this thread.

JS, Thank you once again.

letmywifelive, I'm so sorry.

I was stage IV at dx, I had 2 bone mets, left and right hip area. Acetabulum and iliac. (sp?) Where did your wife's show up?

My medication has been working well, thankfully. ( I should have said pelvis and hip). Best wishes to both of you.

Jumpship, It may be a good idea for you to post on Chrissyb's thread not dx with a recurrence (something like that?). I had no pain until I started the tx but I think that some people do feel pain. Best wishes to you and I hope you are cancer free.