Herbs That May Increase Breast Cancer Recurrence Risk

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This report is from Consumer labs at http://www.consumerlab.com/tnp.asp?chunkiid=35541#herbs

Herbs That May Increase Breast Cancer Recurrence Risk

Women who havehad breast cancer are at high risk for a recurrence. As noted above, use ofestrogen promotes the development of breast cancer, and for this reason it is off limits. However, certain natural products may present a similar risk. Numerous herbs and supplements have estrogen-like properties, including the following:

Contrary to popularbelief, black cohosh is probably not estrogenic.

Othersupplements, such as androstenedione and boron, may raise estrogen levels in the body. Finally, although the herbs dong quai and Panax ginseng do not appear to act in an estrogen-like manner, they may nonetheless stimulate growth of breast cancer cells.92  Women who have undergone breast cancer surgeryshould use these herbs and supplements only under the advice of a physician.

The weak estrogen, estriol, is sometimes advocated by alternative practitioners as a safer choice than standard estrogen. However, test tube studies suggest that estriol is just as likely to cause breast cancer as any other form of estrogen.93 

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Comments

  • Anonymous
    Anonymous Member Posts: 1,376
    edited May 2010

    The urban legend that there are "estrogenic herbs" or foods that cause breast cancer keeps circulating. Somebody posted a scientific study disproving this on this forum but the myths keep resurfacing.

    And test tube studies prove nothing. If what goes on in a test tube counted we would have had a guaranteed cure years ago.

    Anyway, thanks for thinking of us.

  • thenewme
    thenewme Member Posts: 1,611
    edited May 2010

    Hi Agnes17, Thanks for the post! I'm not able to read the links since I'm not a member of consumerlabs, but your post mirrors what I've read in other scientific research.

    Lucy88-I'm not sure exactly what you're referring to as urban myth (actual links or citations for the scientific study would be helpful).  I don't think the OP said there was absolute proof of a cure. In fact, it raised the possibility of inherent risks with certain supplements and advised caution in using them.  Here's at least one scientific study that concludes the same as the OP:

    http://www.ncbi.nlm.nih.gov/pubmed/11875334 

    "RESULTS: Dong quai and ginseng both significantly induced the growth of MCF-7 cells by 16- and 27-fold, respectively, over that of untreated control cells, while black cohosh and licorice root did not. 

    CONCLUSIONS: Our studies show that dong quai and ginseng stimulate the growth of MCF-7 cells independent of estrogenic activity. Because of the lack of efficacy and the potential for adverse effects, use of these herbs in humans warrants caution pending further study. "

  • dlb823
    dlb823 Member Posts: 9,430
    edited May 2010

    Hi, Agnes ~ Like thenewme, I couldn't get into the site to read the full article, so I'm wondering if you or someone can tell me (either from that research or other knowledge) what the problem is with alfalfa, a supplement I've used for many years.  I've never heard alfalfa, which draws a variety of micro nutrients from deep in the ground, termed estrogenic, and it seems to me that its inflammation-fighting properties would be especially beneficial to us now.    Deanna     

  • thenewme
    thenewme Member Posts: 1,611
    edited May 2010

    Hi DLB,

    From Sloan Kettering: http://www.mskcc.org/mskcc/html/69114.cfm

    "Alfalfa sprout extracts exhibit potent estrogenic activity in vitro (9); therefore, patients with estrogen-sensitive cancers should avoid alfalfa supplementation. Further, rats fed alfalfa are more susceptible to colon cancer, although similar effects have not been observed in humans (2). "

    And another source of info:

    http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-alfalfa.html 

  • dlb823
    dlb823 Member Posts: 9,430
    edited May 2010

    Thanks, thenewme!  Very interesting!  What's strange is that I recently had an app't. with the integrative specialist @ UCLA, to discuss diet & supplements, and she never questioned alfalfa, which was on my list of the 15 or so supplements I take.  In fact, I just went back and looked, and she'd noted "OK optimal" next to it.  Hmmmm... I'll ask her about it.    Deanna

  • pip57
    pip57 Member Posts: 12,401
    edited May 2010

    I have to agree that 'test tube' studies are not the most reliable.  But most of our decisions about the supplements and foods that we consider beneficial are also based on the test tube or petri dish.  At best there are very loose studies that show some kind of association with certain items.  Like, people who wear shoes are most likely to get cancer.  

  • thenewme
    thenewme Member Posts: 1,611
    edited May 2010

    Well, CRAP, Prettyinpink!  So it was the *shoes* that did me in?  Ack - I always tried to convince my mom to let me go barefoot - see what happens!

  • Husband11
    Husband11 Member Posts: 2,264
    edited May 2010

    There is definately scientific recognition of phytoestrogens.  Their significance in breast cancer though is mostly uncertain, and it seems the general advice is to err on the side of caution and limit exposure to them if you are hormone receptor positive.

  • Nordy
    Nordy Member Posts: 2,106
    edited May 2010

    A big study just came out on Soy and its safety. You can access it here on this board as it has been proven safe... So I think maybe some of the info on Consumer Labs may be a little outdated. The Eastern diet is high in soy, and it wasn't until they adopted a western diet that there was a significant increase in many types of cancer. Just some "food" for thought!

    www.breastcancer.org/tips/nutrition/new_research/20091208.jsp
  • althea
    althea Member Posts: 1,595
    edited May 2010

    nordy, the link you provided doesn't say one word about genetically modified soy.  A glaring omission imo.  The vast majority of soy products grown in the US are genetically modified. 

  • Husband11
    Husband11 Member Posts: 2,264
    edited May 2010

    I wouldn't say Soy has been proven safe by that study.  It involves Chinese women, who ate soy frequently, still got breast cancer, continued to consume soy, and fared as well as the women who didn't consume soy post treatment.  Flaws: 1) The women consumed soy all their lives, and their bodies may have adapted to it 2) The study uses women who consumed soy while at the same time developed breast cancer.  The nature of their breast cancer could be differrent, and the cancer cell's sensitivity to soy could well be different than women who weren't taking soy while their cancers developed.  How can you say soy is safe if you only include women who got cancer while they consumed  a diet high in soy?  I think this Chinese population of women is too unique to compare to North American women.  It's entirely possible that women who consumed soy and got cancer, and continue to consume soy, are very different from women who don't consume much soy, get breast cancer, and start to consume increased levels of soy.  Its apples and oranges.

     That said, I'm not saying I believe soy is detrimental, I'm just saying that we don't have good answers to the fear that it is.

  • pip57
    pip57 Member Posts: 12,401
    edited May 2010

    Nordy, Soy is one of the most genetically modified crops in the world.  I would be very cautious with it.

  • debisongbird
    debisongbird Member Posts: 275
    edited May 2010

    Thanks for the post. Yeah, I was hoping panax ginseng would be something I could take, since energy is a missing link in my armor. Low, low energy. Any suggestions. I have considered spirulina or blue algae (which I think is safe.) Let me know if you have heard anything about these two being unsafe or causing estrogen growth! Went to buy fish oilcaps yesterday and they were loaded with soy!!!???

  • michelleZ1959
    michelleZ1959 Member Posts: 1
    edited May 2010

    Oh my! my naturopath has put me on Red Clover to help keep my blood healthy, my nutritional councelor put me reveratrol (red wine& green tea) to help with the chemo side effects (i did not take it!) but do take the red clover 2 every day! I guess I shouldnt?

  • Anonymous
    Anonymous Member Posts: 1,376
    edited May 2010

    Michele, Don't pay attention to the urban legends you hear about estrogenic herbs on this board. 

    Studies done with test tubes in specific concentrations are NOT equivalent to humans.

  • thenewme
    thenewme Member Posts: 1,611
    edited May 2010

    Hi MichelleZ1959,

    Unfortunately, there really aren't any easy answers about "should I" or "should I not" take any particular supplement.  We all have to do research and weigh the risks and benefits, considering our own specific circumstances, and make our own choices. 

    Since you're seeing a nutritional counselor and naturalist who are presumably experts you trust and who are familiar with your specific medical needs, you may want to discuss with them your concerns.  There is lots of great information on this board about all things breast-cancer related, but there is also a lot of misinformation.  The fact is we're just strangers on the internet, and we're all learning as we go.

    Here's some information about red clover that you may want to be aware of, especially if your breast cancer is estrogen receptor positive:  SOURCE HERE

    "Do Not Take [red clover] If ....  you have a hormone-sensitive disease such as estrogen receptor-positive breast cancer, ovarian cancer, endometriosis, or others (Red clover may have estrogenic activity and should be avoided or used cautiously by patients with these estrogen-sensitive diseases). "

    ETA- Be sure to get your information from credible and reliable sources and double check everything you read!

  • thenewme
    thenewme Member Posts: 1,611
    edited May 2010

    Hi Lucy88,

    I wonder if you can clarify your statement, "...Don't pay attention to the urban legends you hear about estrogenic herbs on this board.  Studies done with test tubes in specific concentrations are NOT equivalent to humans."

    Which urban legends are you referring to?  Are you saying there are no herbs with estrogenic activity that may be harmful to ER+ breast cancer patients? 

    I also don't remember any one saying that test tube studies are equivalent to humans.  

    If we could all cite our sources when we post (or dispute) specific information, I think it would be so much more helpful for discussion and fact-finding purposes. 

  • mollyann
    mollyann Member Posts: 472
    edited May 2010

    thenewme, you need to read more carefully. Seriously, I worry about you. Do you still have all that time you talked about?

    hugs Kiss

  • Hindsfeet
    Hindsfeet Member Posts: 2,456
    edited May 2010

    ok...estrogen base foods are not the cause of cancer? As I understand, it only feeds the cancer once you have it. Once your cancer is removed, you are cancer free, and these foods in moderation are ok to eat.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited November 2010

    Hello thenewme,

     I can't find any citations for your claims that estrogenic herbs have caused problems in humans. Until we see them in humans and not in test tubes, you are making unproven claims.

    "Not knowing when the dawn is coming, I open every door." -- Emily Dickinson

  • CrunchyPoodleMama
    CrunchyPoodleMama Member Posts: 1,220
    edited May 2010

    Re: the soy debate... not to sound like a broken record, but in the traditional Chinese diet, not only was the soy not genetically modified, but it was also FERMENTED... not consumed the way it's consumed rampantly in the U.S. Those two factors -- GMO vs. organic/non-GMO, and fermented vs. not fermented -- make ALL the difference.

    Just the phytates/anti-nutrients alone in unfermented soy should be enough to tell you to stay away from those types of soy foods -- regardless of its phyto/xenoestrogen status.

  • jessamine
    jessamine Member Posts: 322
    edited May 2010

    I totally agree with poodle mama re: the importance of eating only organic and fermented soy (miso and tempeh). I think it's worth saying too that what they genetically modify FOR is to make the plants more resistant to pesticides, enabling them to apply many many times more than would be possible on natural plants. Definitely not something you want to eat.

  • thenewme
    thenewme Member Posts: 1,611
    edited June 2010

    Lucy88 and Mollyann,

    Two simple questions:

    1. What is the "urban legend/myth"  you insist that I'm spreading?

    2. Do you have sources to share that might be helpful for this discussion? 

  • Husband11
    Husband11 Member Posts: 2,264
    edited June 2010

    I thought the traditional tofu (bean curd) and soy milk were unfermented, and older than Budhism?

  • Janeluvsdogs
    Janeluvsdogs Member Posts: 242
    edited June 2010

    Timothy, this is going to sound like a stupid question but is the soymilk in the supermarket the same as what the Asians consume? What is soy isolate?

  • Husband11
    Husband11 Member Posts: 2,264
    edited June 2010

    I don't know the answer to the question about soymilk today vs traditional, other than that things were made a lot simpler in the past, and less processing.  Probably they just used ground soybean.

     Soy protein isolate is a refined soy product in which the fat and the majority of the carbohydrate portion of the soy flour is removed to leave a higher concentration of protein.  Apparently it can be up to 90% protein content.

  • MsBliss
    MsBliss Member Posts: 536
    edited June 2010

    Unless you are getting Fermented organically grown soy, like a tempeh or an edamame dish, you are likely to get "Round up Ready" soy.  It is a GMO soy crop designed to be unaffected by excessive applications of a weed killer called Round Up.  Secondly, if you don't metabolize estrogen to more favorable types (the "2" methoxyestradiol) you are more likely to have the pro inflammatory estrogens circulating in your body regardless of whether you avoid estrogenic foods or not, so:

    In other words, if you are going to eat soy, make sure it is organic, preferably fermented, and in moderation.

  • Rufusmama
    Rufusmama Member Posts: 19
    edited June 2010
    • I took soy supplements for about 2 years for symptoms of menopause (they did help), drank tons of soy milk, ate soy burgers, etc.  Had breast tenderness and developed "complex" cyst that turned out to be cancer.  I have reported this to the FDA via the MedWatch program. I'm convinced there was a link.  Much of our food now has soy protein, soy flour, or soy of some sort in it.   Breast cancer rates are rising. 
  • joanne_elizabeth
    joanne_elizabeth Member Posts: 499
    edited June 2010

    Soy supplements are dangerous.  Recent research show 11 grams/soy per day in milk, tofu etc can help PREVENT recurrence.

  • peggy_j
    peggy_j Member Posts: 1,700
    edited May 2011

    Bump. Anyone have an opinion of the book The Definitive Guide to Cancer: An Integrative Approach by Lise Alschuler and Karolyn Gazella?  My MO is recommending tamoxifen for me, and this book contains a table listing hormone drugs and herbs that may either be helpful or possibly harmful during treatment. Would love find a reliable source of scientifically-based data.  

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