HYSTER. OOPH. THEN TAMOX?

If you are having an ooph and a hyst, your onc will probably recommend an AI afterward since you will be post meno after having the ooph.  AI's have a statistically better percentage than just tamox but can only be given post menopause.

Hi,

I would suggest that you request a cpy2d6 test to see how well your body metabolizes Tamoxifen.  In some women, they do not metabolize the Tamoxifen well, and that may explain the difference in the AIs appearing to be better in some cases.  I'm going through this right now.  I'm having a hyster/ooph in May, my main onco ran the test and I metabolize Tam well enough to stay on it, which is what I wanted to hear.  I have a 2nd onco I see when making big decisions and he said I should go onto an AI because some women do a little better on them than Tam, I asked him if this could have anything to do with the ability to metabolize Tam and he said yes, but there have been no studies yet as the test is so new. So, again, no studies.  I would at least try and get the test run, if you are not a good metabolizer your doc would probably put you on an AI. My 1st onco and I hope that I can have 10 years of hormonal therapy if I stay on Tam then move to an AI.  As mentioned above, even though you've had a hyster/oohp your body still makes small amounts of estrogen in the paths mentioned above, so I would think you should be on one of the drugs.