HYSTER. OOPH. THEN TAMOX?

idaho

If I have a hysterectomy and oophectomy do I still have to take tamoxifen?  I am premenopausal and 46. 

flash

If you are having an ooph and a hyst, your onc will probably recommend an AI afterward since you will be post meno after having the ooph.  AI's have a statistically better percentage than just tamox but can only be given post menopause.

Anonymous

I had a TAH/BSO at almost 48 and continued with tamoxifen, but that's because I have LCIS (AIs not approved for LCIS); I would think they might switch you over to an AI since you had IDC. Even when  the ovaries are removed, there's still estrogen being produced by the adrenal glands, skin and fat.

Anne

KEW

Hi,

I would suggest that you request a cpy2d6 test to see how well your body metabolizes Tamoxifen.  In some women, they do not metabolize the Tamoxifen well, and that may explain the difference in the AIs appearing to be better in some cases.  I'm going through this right now.  I'm having a hyster/ooph in May, my main onco ran the test and I metabolize Tam well enough to stay on it, which is what I wanted to hear.  I have a 2nd onco I see when making big decisions and he said I should go onto an AI because some women do a little better on them than Tam, I asked him if this could have anything to do with the ability to metabolize Tam and he said yes, but there have been no studies yet as the test is so new. So, again, no studies.  I would at least try and get the test run, if you are not a good metabolizer your doc would probably put you on an AI. My 1st onco and I hope that I can have 10 years of hormonal therapy if I stay on Tam then move to an AI.  As mentioned above, even though you've had a hyster/oohp your body still makes small amounts of estrogen in the paths mentioned above, so I would think you should be on one of the drugs.