Trials coming for TNBC vaccine developed in Jacksonville FL

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cp418
cp418 Member Posts: 7,079
edited December 2017 in Triple-Negative Breast Cancer

http://www.firstcoastnews.com/story/news/health/20...

Trials coming for breast cancer vaccine developed in Jacksonville

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  • Meow13
    Meow13 Member Posts: 4,859
    edited February 2015

    my mo thinks this vaccine for her2+ could be the closest to a cure yet. Unfortunately it wouldn't benefit me but very encouraging for others.

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  • Meow13
    Meow13 Member Posts: 4,859
    edited February 2015

    This vaccine says for triple negative, my mo must have been talking about some other research vaccine

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  • Redporchlady
    Redporchlady Member Posts: 113
    edited February 2015

    I have already contacted Mayo clinic to sign up for the trial and received a letter back that when the trial opens they will contact me.  I also am being treated at a Mayo clinic so my ONC said that they would also scan the database for patients like me to be a part of the trial.  He said would gather more information we could discuss it when it becomes available.  It does give us hope that they are working on a cure.  I pray every night and give thanks to God for the wonderful doctors and nurses that are working to help us rid our body of cancer and to come up with a cure.   

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  • jarris77
    jarris77 Member Posts: 100
    edited February 2015

    I just got a call back from the Mayo Clinic regarding the TNBC vaccine. I was told that the media kind of jumped the gun a little. Said they were expecting to start the trial in early 2016. She put me on the list and said I would receive info as it becomes available. 

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  • DaLyA08
    DaLyA08 Member Posts: 4
    edited February 2015

    Please keep us posted, jarris77. I'm in Colombia. I would really love to know when this trial starts.

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  • jarris77
    jarris77 Member Posts: 100
    edited February 2015

    I will post any info when I receive it. I called the Jacksonville, FL office and was transferred to Arizona. If I understood her correctly, they aren't sure yet which location will actually be performing the trial. She did say it sounds very promising! 

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  • Redporchlady
    Redporchlady Member Posts: 113
    edited February 2015

    Here is what I got from the clinic after signing up for information on the trial.  Roxanne

    02/06/2015

    Thank you for your interest in our cancer vaccine trial and cancer research at Mayo
    Clinic. The cancer vaccine trial is being developed to learn more about how the
    vaccine prevents breast cancer recurrence. 
    We expect that this study will be conducted in patients who have been
    previously diagnosed with early stage triple negative breast cancer who have
    completed surgery and chemotherapy.

    We have received a large amount of calls, but wanted to reply to you as soon as
    possible.  As we get closer to the trial opening in the next year, we will contact you regarding your interest.

    Enclosed is information on prior vaccine research at Mayo Clinic and a variety of
    resources. If you are interested in scheduling an evaluation with one of our specialists
    to talk about other treatment options and clinical trials please call

    Arizona:  800-446-2279

    Florida:  904-953-0853

    Minnesota:   507-284-4137

    Please let me know if I can be of further assistance with any other breast cancer clinical trial options
    at Mayo. Thank you for contacting Mayo Clinic.

    Toni Kay Mangskau

    Clinical Trials Referral Coordinator

    (855-776-0015)

    Abstract on prior research

    http://meetinglibrary.asco.org/print/1153831

    Other Triple Negative Breast Cancer
    Treatment Studies at Mayo Clinic

    https://clinicaltrials.gov/ct2/show/NCT01042379?term=i-spy&rank=1

    https://clinicaltrials.gov/ct2/show/NCT01881230?term=abi-007-mbc-001&rank=1

    https://clinicaltrials.gov/ct2/show/NCT01325441?term=bbi608-201&rank=1

    Various other resources

    www.Tnbcfoundation.org

    www.breastcancertrials.org

    www.researchmatch.org

    www.emergingmed.com

    www.patienttravel.org

    http://www.cancer.org/docroot/subsite/hopelodge/locations.asp



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  • shelleym1
    shelleym1 Member Posts: 298
    edited February 2015

    This is incredible! I am not TN but my friend is. I showed her this article. We are holding out hope that this is going to be a game changer!!

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  • WinningSoFar
    WinningSoFar Member Posts: 951
    edited February 2015

    Oh, it's for early stage. Too bad.

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  • jarris77
    jarris77 Member Posts: 100
    edited February 2015

    Redporchlady, that is the exact email that I received. I called first and then sent an email and got a response from both. I don't know how any of this works, but I was afraid if I waited too long, I would miss the chance to get in on the trial. 

    The article stated that they wanted patients that had tumors that expressed a protein....folate receptor alpa protein. Does anyone know if that is something that we can find out?

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  • gw1945
    gw1945 Member Posts: 1
    edited February 2015

    Just signed up today. I am so excited to be a part of this trial. I feel it may be a breakthrough for all types of cancer in the future. I really hope I will meet the criteria. At this point I don't know if my tumor expressed the Alpha Folate Protein which seems to be a requirement for this trial. It apparently isn't something tested in most pathology reports.

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  • Galht12
    Galht12 Member Posts: 1
    edited March 2015

    I have been trying so hard to find out the status of this trial. I got the same response from Mayo Clinic as most people. How did you get in gw1945?


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  • StefLove
    StefLove Member Posts: 322
    edited May 2015

    The MO I went to for a second opinion mentioned this trial, or possibly another one coming out too, and said that when I finish chemo, rads, etc that they'd probably have more information but she wants to sign me up when the time comes. She said it all depends on my brca testing but she seemed very excited about it.

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  • LillieRose
    LillieRose Member Posts: 112
    edited May 2015

    I want in on this! What do I need to do?! Anyone have info on who to contact? Do I just call the Mayo clinic?!

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  • Addie29
    Addie29 Member Posts: 307
    edited May 2015

    how can I contact them to be put on the list?!

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  • Addie29
    Addie29 Member Posts: 307
    edited May 2015

    I just called them and they told me because I have Medicaid it's a $5000 pre service fee. This is bullshit!

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  • StefLove
    StefLove Member Posts: 322
    edited May 2015

    what?!!! That's insane. And stupid.

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  • Addie29
    Addie29 Member Posts: 307
    edited May 2015

    yeah well I'm still going to get info and try to sign up. We have a way to add insurance through my husbands work if need be.

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  • slv58
    slv58 Member Posts: 1,216
    edited May 2015

    Is there a link to email? I went to the mayo site but can't seem to find anything? Chemo brain!

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  • Addie29
    Addie29 Member Posts: 307
    edited May 2015

    they don't have anything online yet because it isn't open for trials yet. I called to get put on a list.

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  • slv58
    slv58 Member Posts: 1,216
    edited May 2015

    Thank you Addie!

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  • Addie29
    Addie29 Member Posts: 307
    edited May 2015

    you're welcome. It gives us hope and I refuse to miss out on a potentially life saving drug. They didn't even have details about it. But I was told told that once they do and you're signed up you will get details.

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  • LillieRose
    LillieRose Member Posts: 112
    edited May 2015

    what number did you call?! I want on that list! :) thank you!

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  • Addie29
    Addie29 Member Posts: 307
    edited May 2015

    I went online and looked for the FL office number. I called the general number and then they directed me to the appointment line. I explained what I was looking to do and we went from there. They take some info and set up an acoount for you. Then you should receive a phone call from someone in about 3-5 days.

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  • LillieRose
    LillieRose Member Posts: 112
    edited May 2015

    thank you!

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  • JohnSmith
    JohnSmith Member Posts: 651
    edited May 2015

    I'm sure everyone is aware of the upcoming ASCO cancer conference at the end of this month.
    Abstracts were just released to the public. Among them was an abstract dedicated to a Phase 1 trial focused on the immunotherapy vaccine developed by the company TapImmune. As the OP mentioned, Mayo Clinic researchers are collaborating with TapImmune to develop the vaccine.
    Here is the abstract: "A phase I trial of the safety and immunogenicity of a multi-epitope folate receptor alpha peptide vaccine used in combination with cyclophosphamide in subjects previously treated for breast or ovarian cancer."
    Details of this trial will be discussed during the conference in two weeks.

    Here's the details of this Phase 1 clinical trial from clinicaltrials.gov
    Estimated Enrollment: 24
    Study Start Date: July 2012
    Estimated Primary Completion Date: June 2015

    This may not be the exact trial the OP is referring to, but it's certainly a precursor to future vaccine trials dealing with the folate receptor alpha protein. It should also be mentioned that there a number of early stage immunotherapy trials dedicated towards TN.

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  • Addie29
    Addie29 Member Posts: 307
    edited May 2015

    this isn't the same trial they are referring to. I spoke with someone from the mayo clinic yesterday that deals directly with vaccines. This trial isn't released yet and is still waiting for funding. They aren't sure how many people it will be for either.

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  • jlstacey
    jlstacey Member Posts: 277
    edited May 2015

    Ladies, I was given this number to call today: 904-953-2865. It goes to the head of Clinical Trials at the Jacksonville clinic and her name is Cathy. She is out of the office, so I left a message. Thought you all might like to know!

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  • Addie29
    Addie29 Member Posts: 307
    edited May 2015

    that's who I spoke to. Very friendly.

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  • KeepingtheFaith1
    KeepingtheFaith1 Member Posts: 1
    edited September 2015

    Greetings,

    I spoke with a rep. from the Mayo Clinic today. A little update about the TN vaccine study. They are hoping to begin the screening process at the end of the year and are planning to offer the trial at all 3 locations (Jacksonville, FL - Rochester, MN & Scottsdale, AZ). I asked how many potential patients are they anticipating for the program and was told 200. Not sure if it's for all 3 sites or the total for all 3 sites. Just want to share the update. If you are looking for more info the main number at Mayo is 507-284-2111. Everyone that I have spoken with at Mayo has been very helpful, empathetic and professional. #KeeptheFaith

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