Breaking Research News from Breastcancer.org

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FDA Approves Piqray to Treat Advanced-Stage Hormone-Receptor-Positive, HER2-Negative Breast Cancer With PIK3CA Mutation
May 29, 2019
FDA approves Piqray in combination with Faslodex to treat metastatic and advanced-stage, hormone-receptor-positive, HER2-negative breast cancer with a PIK3CA mutation that has grown after hormonal therapy treatment in postmenopausal women and men. Read more...

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Adding Kisqali Improves Overall Survival in Younger Women With Advanced-Stage Hormone-Receptor-Positive Breast Cancer
June 10, 2019
Results from the MONALEESA-7 trial show that adding Kisqali to hormonal therapy and ovarian suppression significantly improves overall survival in premenopausal women diagnosed with advanced-stage, hormone-receptor-positive, HER2-negative breast cancer. Read more...

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Can Treatment Regimens Before Surgery for Early-Stage HER2-Positive Breast Cancer Omit Chemotherapy?
June 11, 2019
Treating early-stage HER2-positive breast cancer before surgery with the combination of chemotherapy, Herceptin, and Perjeta seems to be more effective than the combination of Kadcyla and Perjeta before surgery. Read more...

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Experimental Margetuximab May Help Treat Certain HER2-Positive Metastatic Breast Cancers
June 12, 2019
The experimental targeted therapy margetuximab combined with chemotherapy may help treat pretreated metastatic HER2-positive breast cancer in people with a specific variant of CD16A, a protein that activates immune cells. Read more...

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Adding Clinical Risk of Recurrence to Oncotype DX Score Can Help Make Chemotherapy Decisions for Younger Women With Early-Stage Breast Cancer
June 14, 2019
Considering information about the clinical risk of recurrence of early-stage breast cancer along with the Oncotype DX Recurrence Score results can help refine which women age 50 and younger diagnosed with early-stage hormone-receptor-positive, HER2-negative breast cancer that has not spread to the lymph nodes with a Recurrence Score of 16 to 25 will benefit from chemotherapy. Read more...

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Patients Report Less Fatigue, More Convenience, Slightly Worse Cosmetic Outcomes With Partial-Breast vs. Whole-Breast Radiation
June 14, 2019
Compared to whole-breast radiation, women treated with partial-breast radiation who didn't have chemotherapy after surgery reported less post-treatment fatigue and slightly poorer cosmetic results. They also said partial-breast radiation was more convenient. Read more...

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MRI Finds Breast Cancer at Earlier Stage Than Mammograms in High-Risk Women, but May Result in More False Positives
June 29, 2019
Screening with MRI finds breast cancers at an earlier stage than mammograms in women with a family history of the disease, but this benefit may come with the risk of more overdiagnosis and false-positive results, especially in women with dense breasts. Read more...

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Combining Breast Density Info With 5-Year Breast Cancer Risk Score Helps Determine Which Women Need Additional Screening
July 3, 2019
Combining breast density information with a woman's 5-year breast cancer risk estimate can help doctors better figure out which women should have additional screening beyond yearly mammograms. Read more...

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Ashkenazi Jewish Women Who Know They Have BRCA Mutation Have Better Breast Cancer Outcomes
July 11, 2019
Ashkenazi Jewish women who know they have a BRCA mutation, but decided not to have preventive mastectomy, have better outcomes if they're diagnosed with breast cancer compared to Ashkenazi Jewish women who don't know they have a mutation. Read more...

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Childhood Cancer Linked to Worse Mortality After Breast Cancer
July 12, 2019
Women diagnosed with a childhood cancer who developed breast cancer as an adult were more likely to die after being diagnosed with breast cancer compared to women who did not have childhood cancer. Read more...

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Herceptin Biosimilar for Breast Cancer Now Available in U.S. Market
July 24, 2019
Kanjinti (trastuzumab-anns), a biosimilar for Herceptin used to treat people diagnosed with HER2-positive breast cancer, is now available in the United States. Read more...

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Allergan Issues Worldwide Recall of Biocell Textured Breast Implants and Tissue Expanders
July 24, 2019
On July 24, 2019, Allergan announced a global recall of Biocell textured breast implants and tissue expanders after the FDA requested the action. Read more...

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Delaying Chemotherapy More Than 120 Days After Diagnosis Linked to Worse Survival for Early-Stage Breast Cancer
July 26, 2019
If chemotherapy after surgery is part of a woman's recommended treatment plan for early-stage breast cancer, chemo should be started within 4 months of diagnosis because waiting longer is linked to worse overall survival. Read more...

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ASCO Updates Guidelines on Using Biomarkers to Make Adjuvant Treatment Decisions for Women Diagnosed With Early-Stage Invasive Breast Cancer
August 5, 2019
ASCO updates guidelines on using biomarkers to make decisions about systemic therapies after surgery to treat people diagnosed with early-stage invasive breast cancer to include recent results from the TAILORx trial on using the Oncotype DX test to guide use of chemotherapy after surgery. Read more...

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Using MRI to Follow Previously Diagnosed Women Finds More Breast Cancers, but Leads to More Biopsies
August 5, 2019
MRI monitoring in women previously diagnosed with breast cancer finds more cancers than mammography, but also leads to more biopsies. Read more...

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Abdominal and Intramuscular Fat Increase Risk of Heart Disease in Breast Cancer Survivors
August 9, 2019
Women with a history of breast cancer who have high levels of abdominal and intramuscular fat have a higher risk of heart disease, even if they have a normal BMI. Read more...

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Preventive Ovary Removal in Women With BRCA Mutation Leads to Lower Bone Density
August 13, 2019
Women with a BRCA mutation who have their ovaries and fallopian tubes removed preventively are likely to have lower bone density after surgery, especially if a woman is premenopausal at the time of surgery. Read more...

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Task Force Expands BRCA Genetic Testing Recommendations; More Women Will Be Referred for Counseling and Testing
August 26, 2019
The U.S. Preventive Services Task Force updated its recommendations on risk assessment, genetic counseling, and genetic testing for BRCA-related cancer, saying that women with either a personal or family history of breast or ovarian cancers, as well as women who are Ashkenazi Jewish (Eastern European), should have their risk assessed by their primary care doctor. Read more...

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Home-Based Weight Loss, Exercise Programs Don't Help Breast Cancer-Related Lymphedema
August 26, 2019
Neither weight loss nor at-home exercise programs — nor a combination of the two — improved lymphedema beyond the standard of care in overweight women who had been treated for breast cancer. Read more...

S00

my paternal grandmother got breast cancer in her 80s. They took her left breast. She had a very good doctor in the Midwest. He put her on an oral chemo that took care of it. She lived to be 102 yrs. My mother was the first in her family to get it and after losing the right breast, it returned with a vengence. She lost the left breast after enduring all of the crap, it went to her liver. She lived under the huge AC/DC power lines and it affected many lymph nodes. Her neighbor developed lymphoma soon after. They had her on experimental drugs as the $200 a pill was out of her reach. She was told in September 2008 that she was cancer free. We lost her in March of 2009. I felt they should’ve done more than poke at her and ask if there was pain. I have RADS so when breathing became normal my lung doctor called me in to check my lungs. They found a mass on my left breast. DNA was discovered so they tested the tumor and went after it. I had an excellent surgeon and a great radiologist who took measures to miss my lungs. I had a lumpectomy, lost my thick hair down to my waist. I was focused on my husband who was fighting wegeners vasculitis so my goal was to survive to take care of him. I could only tolerate egg flower soup. We fought together made it not a big thing for me. Some things are as bad or worse than cancer. I rubbed tea tree oil on my sensitive scalp and found only one of the four anti nausea pills worked better than all four. I am 3 years on anastrozole and do many Herbs and vitamins. 8000ut D3. 10mg melitonin to sleep. Lots of side effects from Anastrozole and find hydration helps muscle cramps and B12

S00

take 8000uts of D3& folic acid, use a soft natural brissel brush, tea tree oil to get hair growing. I use a no. 1 shampoo and no.2 conditioner from Sally’s Remember, your hair is new and like baby hair so it’s more fragile. Use a more natural mascara and a little brush to get eyelashes back. Baby oil will help eyebrows and lashes. Keep tea tree oil and the shampoo away from eyes. Natural tears will help the drying of your eyes affecting eyesight. Bag Balm will cool off your bottom as Anastrozole blocks estrogen ( our body’s natural lubrication) and cause raw burning effect. It’s a catch 22 as our body uses estrogen to keep things working. That’s why muscles stiffen and hurt. B6 will keep your hair in and blood pressure can be brought back down using potassium complex and eating a banana. Take care and be careful about scratching that dead arm, you can claw it pretty bad if you can’t feel it. All the Bes

Moderators

Receiving Less Than 85% of Planned Chemotherapy Dose Affects Early-Stage Breast Cancer Survival
August 29, 2019
Women diagnosed with early-stage HER2-negative breast cancer who received less than 85% of the planned total dose of chemotherapy had worse survival than women who received 85% or more of the planned dose. Read more...

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FDA Says Men Should Be in Breast Cancer Studies
August 29, 2019
Men should be included in breast cancer clinical trials, according to draft guidance issued by the FDA. Read more...

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Small Study Finds High Rate of Gene Mutations in People Diagnosed With Metastatic Breast Cancer
September 3, 2019
Of 100 people diagnosed with metastatic breast cancer, 14 had a genetic mutation linked to the disease and 21 had a variant of unknown significance, according to a small study. Read more...

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In Appropriate Women, Nipple-Sparing Mastectomy Doesn't Lead to Higher Breast Cancer Recurrence Rates
September 4, 2019
Rates of breast cancer recurrence in the nipple/areola area after nipple-sparing mastectomy with immediate reconstruction were low as long as the characteristics of the breast cancer were considered when deciding who should have the procedure. Read more...

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Updated ASCO Guidelines Add Arimidex to Recommended Risk-Reducing Medicines for Women at High Risk of Breast Cancer
September 6, 2019
Arimidex is now an option to lower breast cancer risk in postmenopausal women at high risk of the disease who have not been diagnosed, according to updated ASCO guidelines. Read more...

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FDA Warns About Rare but Severe Lung Inflammation Linked to Breast Cancer Drugs Ibrance, Kisqali, and Verzenio
September 17, 2019
On Sept. 13, 2019, the FDA released a statement warning about a link between rare but severe lung inflammation and the three CDK4/6 inhibitors used to treat advanced-stage hormone-receptor-positive, HER2-negative breast cancer. Read more...

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FDA Warns About Probable Carcinogen in Zantac
September 18, 2019
On Sept. 13, 2019, the FDA warned that some ranitidine medicines, including Zantac, contain low levels of NDMA, a probable human carcinogen. Read more...

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Men at High Risk for Breast Cancer Benefit From Mammograms
September 19, 2019
Mammography screening offers benefits to men with a high risk of developing breast cancer, according to a study. Read more...

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Men With Breast Cancer Have Lower Survival Rates Than Women
September 23, 2019
A study found that men have lower overall survival compared to women after a breast cancer diagnosis. The characteristics of the breast cancers and undertreatment of male breast cancer seem to account for much of the difference in survival. Read more...