Tamoxifen and singing voice

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I finished radiation 3 weeks ago. The day after, I started the tamoxifen. Immediately I felt “different" but I've been pushing though. The one side effect that I did not anticipate was the weakening of my singing voice. I had done some initial reading about side effects—but did not come across mention of the loss of a singing voice. This is the most distressing issue for me on this drug—as I'm a singer (not professionally but I've sung all my life). I can't ignore the fact that my vocal range is wispy and weak.
Has anyone else experienced this? Is there anything that can be done? There may be some vocal exercises—but I'm afraid of the damage being done to my vocal cords.
My diagnosis was ILC and my oncotype was 9. ILC has more potential to reoccur in the opposite breast—so I feel I need to take the estrogen blockers but my score was low—which makes me wonder if the risks of taking it are worth it.
Wanted to reach out to the community to hear your thoughts.

Comments

  • flashlight
    flashlight Member Posts: 698
    edited December 2020

    Vainandafraid, I have never heard of this, but that doesn't mean anything!! I was wondering if you developed a cough or sore throat during radiation? If not, Tamoxifen gave me bad heartburn which can make your voice raspy from the acid reflux. It helped me to decrease my dose to 10mg, after taking a few days off, and slowly increasing to 20mg. I still take 10mg twice a day.

  • Mom2bill
    Mom2bill Member Posts: 5,342
    edited December 2020

    I have actually come across a change in singing voice on some lists of Tamoxifen side effects. I developed some hoarseness a few weeks ago and am thinking it could be related to the medication.

  • Beaverntx
    Beaverntx Member Posts: 3,183
    edited December 2020

    Had not made the connection to Tamoxifen, but my vocal range narrowed so that I could not reach the upper soprano notes or the lower alto notes. Ended up leaving the church choir because I was totally frustrated. Hmmmm...

  • AliceBastable
    AliceBastable Member Posts: 3,461
    edited December 2020

    My voice change is from radiation, not Tamoxifen.

  • WC3
    WC3 Member Posts: 1,540
    edited December 2020

    Vainandafraid:

    I'm glad you mentioned this because I've experienced something related but have never previously said anything about it because it's odd.

    I'm also not a professional singer but have done Karaoke in the past and am a regular shower singing and I like to be able to carry a tune if just for my own sake. A few years ago I was put on a low dose of testosterone because. This was too low of dose to drop my voice or anything like that but I completely lost the ability to sing on key. This seemed like a sound processing issue like I just couldn't find the note in my head. It resolved when I went off the testosterone.

    When I went on the tamoxifen, I noticed my ability to sing on key drastically improved.

    I'm now off the tamoxifen and on anastrazole which I think may increase my testosterone so we will see what happens with my singing abilities.

  • Vainandafraid
    Vainandafraid Member Posts: 6
    edited December 2020

    I appreciate all of your responses. I came across “change to singing voice” as a potential side effect on a few sites about tamoxifen. I could tell there was a difference in my voice after a few doses. This is super distressing to me. I’ve read a little about toremifene. It’s also a SERM. I’m wondering if it would affect the voice as well.

  • buttonsmachine
    buttonsmachine Member Posts: 930
    edited December 2020

    vainandafraid, my personal theory is that voice changes from hormone medicines are due to just that: the changes in our hormones brought about by these drugs.

    If you think about it, our voices are very sensitive to hormones. They change at puberty (okay, more for guys), and as we become older and lose our hormones due to natural menopause. Think of all the singers out there who don't sound the same at 70 as they did at 30. I also had a friend from choir who usually sang alto, but could sing tenor while pregnant!

    I don't think it's just you though. When I was on aromatase inhibitors and ovarian suppression my vocal range got noticeably smaller. I was singing in a band with friends at the time and it became frustrating to hit both higher and lower notes in my normal register. I also felt that my voice quality changed very slightly, but it was mostly just noticeable to me.

    It's hard when treatment disrupts the things we love and care about. I hope you find a good solution, keep us posted.

  • Vainandafraid
    Vainandafraid Member Posts: 6
    edited December 2020

    Buttons-You make good points about hormones and vocal sensitivity. I can still sing in my middle register but higher and lower notes aren’t as strong. Such a bummer.
    Did your voice “come back” after taking the AIs?

  • buttonsmachine
    buttonsmachine Member Posts: 930
    edited December 2020

    Vainandafriad, I think my voice came back, but since I jumped into other meds it's hard to say for sure. Also, in my case I unfortunately had a metastatic recurrence which has caused other troubles (I feel of breath sometimes due to that, for example).

    It's a tough call. I would recommend doing what you can to prevent a recurrence - because believe me, life does not get easier when your cancer comes back. That being said, it's important to prioritize the things that are important to you in life NOW, and hang on to those. For example, I switched from AIs to Faslodex because the AIs were causing problems in my hands, and making it so I couldn't play the piano. The Faslodex did not cause that problem, so I could have effective hormone medicine, and keep up my music.

    I'm not saying you should do Faslodex ;-) but what I am saying, is talk to your doctor and see if there is a "middle way" of treating your cancer and also maintaining what is important to you. There might be. Ultimately it is your decision. But quality of life is SO important too.

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