Taxol in tablet form?

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Anotherone
Anotherone Member Posts: 633
edited October 2019 in Stage IV/Metastatic Breast Cancer ONLY

any news about this ?

https://www.onclive.com/publications/oncology-live/2018/vol-19-no-21/novel-oral-paclitaxel-formulation-aims-to-overcome-drawbacks-of-iv-version

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  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2019

    still in clinical trials. I think I saw someone on this board say they were getting it but they may have been on the trial

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  • ShazzaKelly
    ShazzaKelly Member Posts: 909
    edited July 2019

    It’s still in trial. I took it for 2 years, I found it much easier than the iv ver

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  • Daniel86
    Daniel86 Member Posts: 271
    edited July 2019

    Shazza, just out of curiosity, what were the SEs you/others experienced? Neuropathy? Did you lose your hair?

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  • pajim
    pajim Member Posts: 2,785
    edited July 2019

    This is Oraxol. There were a number of posters about it at ASCO this year. It's an oral form of Taxol. It's mostly being studied in South America but there are some trials in the US. Dana Farber was doing a sort-of Phase 1 of it. The Phase 3 is out of South America and is due to be finished at the end of this year.

    They have shown that the blood levels of Oraxol and Taxol are the same. So the bioavailability is OK. Which means the effectiveness is probably the same but not a sure thing. The digestive tracts does all sorts of things to drugs. The rumor is that the side effects are not as bad. The posters I saw said so but I don't know enough about the SEs of either drug to tell whether that was drug company hype.

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  • ShazzaKelly
    ShazzaKelly Member Posts: 909
    edited July 2019

    I lost my hair on the iv version but after 2 years it had grown back a bit. Once I swapped to Oraxol it came in thicker and returned to its pre chemo self. I had had my iv dose reduced over time to combat neuropathy, nausea and general fatigue. When I started Oraxol my dose was much higher but I had no real side effects.

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  • ann273
    ann273 Member Posts: 209
    edited October 2019

    Looks like there's been some progress on oral taxol.

    https://www.fool.com/earnings/call-transcripts/2019/08/07/athenex-inc-atnx-q2-2019-earnings-call-transcript.aspx

    They also plan to release results at the San Antonio Breast Cancer Conference.

    The good thing seems to be that the side effects profile seems a lot better including no hair loss.

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