Breaking Research News from sources other than Breastcancer.org
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Lumpie, that link about the Elephants having genes that cause cells with mutation errors to commit suicide is so very interesting! Coming from a humorous standpoint, it makes me wonder if fossils of dinosaurs might have dna with similar genetic code. I mean what's bigger than Elephants? Oh maybe a Brachiosaurus???! LOL. But this really is so exciting to learn. IMO there is SO much we can and should be learning from Elephants. I've always been enamoured by them. Thankfully I was able to go to AFrica as a part of my college studies back in the 90s and see herds of them that stretched for as far as the eye could see. Just amazing creatures.
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And whales! "Scientists know that age and weight are risk factors in the development of cancer. That should mean that whales, which include some of the largest and longest-lived animals on Earth, have an outsized risk of developing cancer.
But they don't. Instead, they are less likely to develop or die of this enigmatic disease. The same is true of elephants and dinosaurs' living relatives, birds." (sorry can't post links yet)
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Pairing targeted drugs for breast and lung cancer could overcome treatment resistance
Targeted drugs for breast and lung cancer could be used together to overcome resistance to treatment in several different tumour types, a new study shows. Scientists discovered that when the breast cancer drug palbociclib was combined with the lung cancer drug crizotinib, the two-drug combination was significantly more effective against cancer cells in the laboratory than either drug used on its own...
Based on this discovery, the researchers found that pairing CDK4/6 inhibitors such as palbociclib together with crizotinib -- which blocks MET activity -- created a combination treatment that was much more effective than either drug on its own against cancer cells grown in the lab or human tumours growing in mice.
https://www.sciencedaily.com/releases/2019/07/190711200609.htm
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How cell-free DNA (cfDNA) can be targeted to prevent spread of tumors
"After infection or injury, a group of specialized immune cells called neutrophils release small sticky fibers of chromatin, which is undegraded dead-cell DNA. These fibers are called neutrophil extracellular traps (NETs). Although NETs can stop harmful bacteria from spreading in the bloodstream, NET release can sometimes become uncontrolled; this could cause clotting or embolism (lodging of the clot inside a blood vessel), a potentially fatal condition. Prof Mizuta states that DNase1L3 can degrade NETs into cfDNA and thus be used to treat thrombosis caused by NETs.
NETs are also known to be the "seeding soil" for tumors. Tumor cells released in blood might latch onto NETs and grow on them and spread to other organs. For this, Prof Mizuta says, "Because DNase1L3 degrades NETs and generates cfDNA, we speculate that DNase1L3 treatment may also be useful to prevent tumor metastasis. We are now conducting experiments to test this speculation."
That said, can more research on cell-free DNA make human life cancer-free? Only time will tell..."
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Imprinted Spheres Fight Breast Cancer: Inhibition of HER2 on tumor cells by molecularly imprinted nanoparticles
A particularly aggressive, metastasizing form of cancer, HER2-positive breast cancer, may be treated with nanoscopic particles "imprinted" with specific binding sites for the receptor molecule HER2. As reported by Chinese researchers in the journal Angewandte Chemie, the selective binding of the nanoparticles to HER2 significantly inhibits multiplication of the tumor cells.
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Typical and atypical presenting symptoms of breast cancer and their associations with diagnostic intervals: Evidence from a national audit of cancer diagnosis
Includes a long list of breast cancer symptoms, a Venn diagram of different categories, and analysis of how non-lump and non-breast symptoms may lead to delay.
https://www.sciencedirect.com/science/article/pii/S1877782117300565
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Debbew - is this the article you were referring to? Seems interesting if so. I'm currently in a "lump" + "non lump" symptoms group with this "new" thing that is going on with my Left nipple. Guess we'll see what my SO makes of it next week. Thanks for the article. The Venn diagram was easy to understand.
'Typical and atypical presenting symptoms of breast cancer and their associations with diagnostic intervals: Evidence from a national audit of cancer diagnosis'
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Oops, I've fixed my link. Thanks for catching that! Yes, you found the same study. Thanks and hoping for a good outcome for you!
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I'd be curious to knw if any set of symptoms correlated with -type of cancer, -grade of cancer, -survival outcomes...?
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santabarbarian, symptoms like you might have experienced pre-dx? Good question.
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I had a red spot and a small fever, like a breast infection. I poked the area and sure enough a lump too. Came on all of a sudden from nowhere.
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my breast felt very itchy above where the tumor was but i could not feel a lump there... found on mammo
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Low Dose Naltrexone
Low dose naltrexone, referred to as LDN, is given as a capsule in the 3 mg to 4.5 mg range for cancer, as opposed to the 50 mg dose given for addiction. [1]
Low dose naltrexone might exert its effects on tumor growth through a mix of three possible mechanisms:
- By inducing increases of metenkephalin (an endorphin produced in large amounts in the adrenal medulla) and beta-endorphin in the blood stream;
- By inducing an increase in the number and density of opiate receptors on the tumor cell membranes, thereby making them more responsive to the growth-inhibiting effects of the already-present levels of endorphins, which induce apoptosis (cell death) in the cancer cells; and
- By increasing the natural killer (NK) cell numbers and NK cell activity and lymphocyte activated CD8 numbers, which are quite responsive to increased levels of endorphins. [2]
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Curcumin plays a vital role in fighting cancer
Sunil Pai, MD +
https://www.cancertutor.com/vital-role-curcumin-ca... -
Stolen from skyfly on another thread:
MIT supercharges cancer immunotherapy with a booster vaccine
"The team tested the vaccine on mice that had glioblastoma, melanoma or breast cancer, and saw a huge improvement in the T cell response. The mice were given about 50,000 CAR-T cells and then given a booster vaccine the next day, and then again a week later. In 60 percent of the mice, the tumors were completely eliminated. That's likely thanks to the boost in CAR-T cell numbers, which two weeks after treatment make up 65 percent of the total T cell population.
By contrast, in the mice that were given CAR-T cells but not the vaccine, there was no effect on the solid tumors and the CAR-T cells themselves were hard to detect in the bloodstream.
The technique also seemed to prevent the tumors from coming back later on."
https://newatlas.com/vaccine-supercharges-cart-cell-cancer-therapy/60550/
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Blood-Based Markers Key to Precision Medicine Approach in Breast Cancer
Mark E. Burkard, MD, PhD, discussed the significance of utilizing markers in the blood and highlighted emerging actionable mutations in breast cancer.
(Registration at onclive.com is free
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Researchers determine epigenetic origin of docetaxel-resistant breast cancer
"Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) have published a study in Molecular Cancer Research in which they identify methylation patterns associated with different subtypes of breast cancer... '[W]e have identified changes in the methylation of specific genes that can improve the classification of patient samples, thus helping us know whether they will respond to docetaxel treatment or not,' Dr. González-Suárez says. 'The differentially methylated genes identified can help us find treatments associated with the new subgroups.'"
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Broken heart syndrome may be linked to cancer, study suggests
Can cancer break your heart? A new study suggests that there's a link between cancer and a condition called broken heart syndrome.
The study, published Wednesday in the Journal of the American Heart Association, found that 1 in 6 people with broken heart syndrome had cancer, and that these patients in particular were more likely to die within five years, compared with broken heart syndrome patients without cancer.
Broken heart syndrome, which is also called stress cardiomyopathy or takotsubo cardiomyopathy, is a temporary condition that can be brought on by stressful situations. During broken heart syndrome, one part of the heart stops pumping normally, which may cause the rest of the heart to pump more forcefully, according to the Mayo Clinic.
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My 5-Month Interlude as a Disabled Professor
{A professor reflects on his period of disability. Many of us will relate to how our lives change when we are affected by a disabling condition.... such as cancer....}
"...my five-mouth travail provided a glimpse of an unnerving alternative reality for me as a classroom teacher. It caused me to see with new eyes how even seemingly insignificant things can create major obstacles for disabled faculty members and students as they go about trying to teach and learn on a college campus."
{No subscription required for this article but you may need to sign in.}
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Cancer Cells Switch Sugar for Fatty Acids to Spread Around the Body
Scientists have uncovered a crucial change in cancer cells that allows them to spread around the body – by switching from sugar to fatty acids to fuel their growth.
"We found that high levels of the protein AKR1B10 help tumour cells adjust to new environments as cancer spreads from the breast to other organs such as the lungs.
This research significantly improves our understanding of cancer cell metabolism and metastatic relapse and could lead to new avenues of exploration for new therapies and treatments for patients with metastatic breast cancer."
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Another way to knock out the nasties!
I hope some of the remarkable research being done gets the funding to work with humans! Would be good if Governments could speed up these protocols for terminal patients
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Cancer survivors are twice as likely to suffer from chronic pain
Researchers estimate over five million survivors struggle with the condition
A new study explored a unique symptom common to over five million cancer survivors: chronic pain.
According to researchers, cancer survivors are twice as likely to struggle with chronic pain compared with those who never had the disease.
"This study provided the first comprehensive estimate of chronic pain prevalence among cancer survivors," saidresearcher Dr. Changchuan Jiang. "These results highlight the important unmet needs of pain management in the large, and growing cancer survivorship community."
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Aggressive breast cancers more likely to hit black and younger women
Black and younger women face elevated risks of developing breast cancers that are not only aggressive but also less responsive to treatment, a new study confirms.
Conclusions: The results of the current study demonstrated that there is a significant burden of disease in TNBC diagnosed among women of color, specifically non‐Hispanic black women, and younger women. Additional studies are needed to determine drivers of disparities between race, age, and stage of disease at diagnosis.
https://onlinelibrary.wiley.com/doi/10.1002/cncr.32207
https://doi.org/10.1002/cncr.32207
{Don't they keep doing this research and finding the same thing?}
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Have Cancer, Must Travel: Patients Left In Lurch After Hospital Closes
Another example of an all too familiar trend — a rural hospital closes forcing patients to travel long distances to receive the care they need. The article looks at the impact on cancer patients in particular, as well as the community at large, when a local hospital like this shuts down. "Rural cancer patients typically spend 66% more time traveling each way to treatment than those who live in more urban areas, according to a recent national survey by ASCO."
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Billionaire Sean Parker is nerding out on cancer research. Science has never seen anyone quite like him
An interesting article that looks at how billionaire Sean Parker, known as an innovator and disruptor in Silicon Valley, is bringing his approach and money to cancer immunotherapy.
"While 'medicine in general can be so staid and cautious,' said D.A. Wallach, a life sciences investor who has known Parker since around 2011, 'you've got in Sean a billionaire who doesn't need to answer to anyone, who's incredibly intellectually engaged with this science, and who has believed for a long time that he knows what the answer's going to be.'"{Most Stat articles require a subscrition, but I was able to access this one.}
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{Don't they keep doing this research and finding the same thing?}
YES.
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'Big Three' Diagnostic Errors Account for Nearly 75% of All Serious Harm | HealthLeaders Media
KEY TAKEAWAYS
Diagnostic errors that led to death or permanent disability were linked with misdiagnosed cancers (37.8%), vascular events (22.8%) and infections (13.5%) — which led the researchers to refer to them as the 'big three.'
Half of the most-severe harm cases ended in patient death and the other half resulted in permanent disability.
Failures of clinical judgment caused more than 85% of the misdiagnosed cases.
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Paige touts study that validates its cancer diagnosis AI
Artificial intelligence-aided pathology company Paige said today that a new study has found that its computational decision-support systems can help clinicians diagnose and treat cancer. Published in Nature Medicine, a paper on the study describes an AI system for computational pathology that achieves clinical-grade accuracy levels. Researchers developed deep-learning algorithms to build a system that can detect prostate cancer, skin cancer and breast cancer with near-perfect accuracy, according to the paper.
https://www.nature.com/articles/s41591-019-0508-1
DOI: https://doi.org/10.1038/s41591-019-0508-1
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