Ringworm drug for dogs (Fenbendazole) might also cure cancer

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  • Cure-ious
    Cure-ious Member Posts: 2,626
    edited June 2019

    Also, Halaven crosses the blood-brain barrier, here is an abstract:

    https://abstracts.asco.org/239/AbstView_239_254493...



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  • AllyBee
    AllyBee Member Posts: 128
    edited June 2019

    Mike- I've seen people on a few different combinations with carboplatin on here. I don't know too much about it but it probably depends on what chemos have been tried previously. I did carboplatin with gemcitabine, others I've seen mention carboplatin with tamoxifen. Carboplatin seems like a common choice for TNBC. I found the side effects fairly tolerable just hard on the platelet counts and started having abnormal liver enzyme levels. My brain met was surgically removed so I don't know how effective it was in my brain but it cleared up a local recurrence in my lymph nodes after 3 cycles. Hopefully it cleared up any micro-nasties in my brain too.

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  • mike3121
    mike3121 Member Posts: 410
    edited June 2019

    Cur-ious, thanks for the info. I don't speak "Doctor" but I guess it says it crosses the Brain Blood Barrier. Eribulin's been out for general use some 6 years yet the article is dated 2019 so why are they just finding this out? It would be great. However, my wife was taking eribulin when she developed cancer to the dura brain lining. Yet my wife had done so well under eribulin she was given 3 months off no chemo so maybe that's when the cancer made it to her brain.

    Ally-Bee, I did understand enough "Doctor speak" to read that carboplatin does cross the BBB.

    I've been yapping away on this site lately, well I'm scared and maybe when I meet with the doctors I'll be able to ask some intelligent questions.

    I found this online and many other places also say the same thing:

    "Eribulin does not cross the healthy blood–brain barrier (BBB), but could have the potential to do so after cranial radiation therapy."

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  • Cure-ious
    Cure-ious Member Posts: 2,626
    edited June 2019

    Well, I really know nothing about Halaven, brain mets or triple-negative disease, but if your wife did respond to Halaven before, there is a trial combo with a CXCR4 inhibitor that has been getting some buzz, might be worth asking her onc about..

    https://www.targetedonc.com/news/fda-grants-balixa...


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  • mike3121
    mike3121 Member Posts: 410
    edited June 2019

    Halaven (eribulin) does not cross the brain blood barrier.

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  • blainejennifer
    blainejennifer Member Posts: 1,848
    edited June 2019

    Guys,

    I got the "talk" from MO on Friday. My platelets are too low for some treatments, and my liver too compromised for others. For now, am doing a Hail Mary by recycling Faslodex.

    So, I wondered if any of you all has run across information on how Fenbendazole interacts with the liver. So far, I think I'm good at the low doses in Joe's protocol.

    Also, has anyone heard about canine Fenbendazole being cut with an estrogenic filler?

    Onward and upward,

    Jennifer

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  • NicoleRod
    NicoleRod Member Posts: 2,906
    edited June 2019

    blainjennifer I will be watching for a reply to your post that is a great question about Fenben and liver.

    I am sorry you are not able to utilize certain treatments now but I am encouraged by how positive you sound.


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  • snooky1954
    snooky1954 Member Posts: 883
    edited June 2019

    Jennifer--- Most of the folks on Joe's fB page claim there is no reaction with the liver.  But I know of no scientific study that would prove that.

    Might I suggest that you join Joe's FB page and read some of the testimonies?  Also, "frisky" (miaomix) emails Joe and he answers fairly quick, so you might try that.

    You are in my prayers Jennifer, that Faslodex  once again works for you.   HUGS,   S

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  • JMouse
    JMouse Member Posts: 78
    edited June 2019

    mike3121, I understand that in addition to cranial radiation therapy, ultra sound is being studied for use in temporarily "opening" the blood-brain barrier.

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  • Cure-ious
    Cure-ious Member Posts: 2,626
    edited June 2019

    Jennifer- My apologies, but I can't remember- did you do well on a CDK4,6 inhibitor? I don't see it in your list, did the cancer have FGFR1 mutation

    Mike-Abemaciclib does cross BB barrier, and they are testing it for triple-negative cancers, any idea what they are finding? or perhaps she already tried it, can't recall everyone's therapies

    https://clinicaltrials.gov/ct2/show/NCT03130439


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  • Yndorian
    Yndorian Member Posts: 263
    edited June 2019

    Mike, DMSO 70% taked orally or by skin carries any drug through the entire body, included brain and bones. HUGS

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  • Yndorian
    Yndorian Member Posts: 263
    edited June 2019

    DMSO also has an anti-tumoral and anti-inflammatory activity by itself. It hasn't SE

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  • mike3121
    mike3121 Member Posts: 410
    edited June 2019

    Yes, I Googled it and it clearly shows it passes through the BBB. Also, how it has healing properties as well. However, I can't find where it binds with other chemicals and carries them through the BBB. Even if it did this binding of chemicals, it would require years of investigation by the FDA and Big Pharma. Thanks though, heartened by your concern.

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  • JMouse
    JMouse Member Posts: 78
    edited June 2019

    blainejennifer, I'm so sorry you're going through this. I hope the Faslodex Hail Mary works out and Fenbendazole mops up after.

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  • Yndorian
    Yndorian Member Posts: 263
    edited June 2019

    Blainejennifer: Excuse my interference. Standardized milk thistle works miracles to recover hepatic functions. You can give it a try while you take Faslodex, then can go with FZ. Fenben has low toxicity, and Joe says on his page that it's sad that many people wait to try the FZ when it is already late. I whish you a quick improvement, with all my heart!

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  • Frisky
    Frisky Member Posts: 1,718
    edited June 2019

    Yndorian...do you use the over the counter DMSO?

    Liquid or cream?

    I want to use it on my sore muscles...what do you recommend i get?

    I would buy it on Amazon...


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  • Yndorian
    Yndorian Member Posts: 263
    edited June 2019

    Frisky, I use 70 % liquid DMSO. I obtain it from a drugstore but you can get online too. It really helps with muscle pains, but it has the oddor issue if you take it oraly, so I take oraly MSM and use DMSO by skin

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  • Frisky
    Frisky Member Posts: 1,718
    edited June 2019

    Thanks Yndorian, I take MSM but I've never tried the DMSO...I think it's time to see if it can relieve some of these aches and pains...

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  • Frisky
    Frisky Member Posts: 1,718
    edited June 2019

    And then we wonder why the world rejects our contaminated and disgusting food supply....I swear right here and now, that if God grants me my wish, the first thing I’ll do, will be to pack and go back to Europe....

    FDA confirms PFAS chemicals are in the US food supply
    The US Food and Drug Administration confirmed that PFAS chemicals have made their way into the US food supply. On Monday, the FDA publicly acknowledged the initial findings of the agency's investigation into how the "forever chemicals" have been detected in the foods we eat.

    Read in CNN: https://apple.news/AX9zrU7yZTies7xLeGkhvwg

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  • Chemokaze
    Chemokaze Member Posts: 208
    edited June 2019

    Verzenio (Abemaciclib) crosses the BBB

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  • mike3121
    mike3121 Member Posts: 410
    edited June 2019

    Sounds great but not used for TNBC.

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  • Yndorian
    Yndorian Member Posts: 263
    edited June 2019

    https://www.curezone.org/forums/fm.asp?i=1622323

    Mike : this link has good information. Specialy the part that talks about the bht (butilhidroxitolueno). It cross the bbb and stop mets. Please read it. I'm sorry about my interference but I trying to help. God bless you and your loved wife

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  • snooky1954
    snooky1954 Member Posts: 883
    edited June 2019

    frisky

        I used DMSO a year or two ago, waited a minute or two and than added aloe vero to top of it.  It definitely helped with pain. I purchase the aloe vero from amazon.  also mixed bakingsoda /water mixture on top of it (for breast tumor and had great results)   It's late and I had chemo this a.m  brains not functionly 100%..   Will find the info and get it to you ASP

    I'm so glad that you're better on the new Ibrance.  

    About the aloe ,   it's so much better if you buy your own plant, then you know what you're getting.

    S

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  • mike3121
    mike3121 Member Posts: 410
    edited June 2019

    Yndorian, good or even bad information is not interfering. Sounds interesting I'll look at it.

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  • santabarbarian
    santabarbarian Member Posts: 3,085
    edited June 2019

    IV high dose C is very active against cancer, and a cursory peek at Google says there are ways of getting C across the blood brain barrier...

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  • snooky1954
    snooky1954 Member Posts: 883
    edited June 2019

    Yndorian…...I absolutely second Mike's opinion..   You're more than welcome here.  S

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  • snooky1954
    snooky1954 Member Posts: 883
    edited June 2019

    Ha,ha.   Yndorian…….I've sure the odor from DMSO will NOT bother Frisky.   It smells like garlic and with her Italian roots i'm sure she won't mind.


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  • Frisky
    Frisky Member Posts: 1,718
    edited June 2019

    Snooky I beg to differ...garlic is excellent in certain dishes...but not as a body scent...bergamot is more likely....Thus my favorite and only cologne is Blenheim by Penhaligon....

    image

    is the unscented DMSO okay? I was thinking about using it as a bodycream...


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  • Husband11
    Husband11 Member Posts: 2,264
    edited June 2019

    You need to be very careful with the use of dmso. Because it so readily transports substances across the skin and into the blood stream, you have to be very careful to not contaminate the area you apply it to, else you risk absorbing internally whatever is on your skin.

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  • Frisky
    Frisky Member Posts: 1,718
    edited June 2019

    Thank you for the warning Husband!

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