Minimum and maximum Taxol treatments ?

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Lily55
Lily55 Member Posts: 3,534

I know that everyone is different but I cannot get anything out of my oncologist (and I cannot change).

What is minimum treatment cycle for Taxol on its own? Two?

I gather that 8 is a typical normal number of sessions (24 treatments)

But is there a different maximum?

I am finding the lack of information very difficult and although treatments are weekly I am only allowed to speak to the Oncologist once a month


Comments

  • Larkin
    Larkin Member Posts: 58
    edited May 2019

    Don’t know minimum for sure but we used it in 3 Round sets before rescanning so I’m guessing three. Max I was told was around two years but obviously that depends on how your body does with it and how it works on your cancer

  • JFL
    JFL Member Posts: 1,947
    edited May 2019

    Lily, I think the maximum is something along the lines of the MO will continue it as long as it continues to work and so long as the side effects are tolerable. Usually neuropathy would be the dose limiter. Sometimes a mets patient may do a shorter, pre-set course via some agreement with the MO based on patient preferences (if a patient is only willing to take it only for a limited period of time) or an MO may have a pre-set course in mind for someone as their first treatment after visceral mets (such as liver) with the idea to move to hormone therapy or something else more tolerable after containing the visceral mets. However, those cases seem to be more the exception than the rule. I am severely allergic to Taxol but have no issues with Abraxane, the albumin-bound version of paclitaxel. I took it for about seven months, until I couldn't handle the neuropathy anymore. I was disappointed and wanted to stay on it longer. However, I was on an abnormally high, power dose administered every three weeks which carried more side effects than the standard weekly dose. I liked the quality of life of only going to get the infusion every three weeks but the toxicity was higher.

  • pajim
    pajim Member Posts: 2,785
    edited May 2019

    I haven't had Taxol in the MBC setting yet but it's my next drug so I've looked into it.

    At my center the normal cycle is three weeks on one week off, though a friend got it down to two weeks on two weeks off. I hadn't heard that there was a maximum number of cycles. This is not Adriamycin for which there IS a maximum number of doses. It's "as long as it works or as long as you can tolerate it"

    Can you ask the nurses for explanations? Your cancer center probably has a protocol around this. Normally patients start on the protocol then change if there is need. It's a bummer you can't talk with your MO, but I've found that nurses know more about the practical matters anyway.

    DId you stop in to the Weekly Taxol thread? They may be able to answer your questions too.

  • ShazzaKelly
    ShazzaKelly Member Posts: 909
    edited May 2019

    I have been on both iv and the new oral versions of taxol. I was on for a combined total of 4 years. We just carried on till it stopped working. I don’t think there s an upper limit for it. You just stay on till it fails or SEs get too much. It’s been my favourite chemo.

  • theresa45
    theresa45 Member Posts: 314
    edited May 2019

    ShazzaKelly - That's great that you taxol was effective for you for 4 years. Were you on a trial for an oral version of taxane? How was the oral taxane from a side effect perspective? Did it appear to work as well or better than IV taxol? I'm currently on Xeloda, but may have to switch soon and am considering options.

    What treatment are you on now? I hope that you are a long term responder to many treatments!!

    Thanks! Theresa

  • ShazzaKelly
    ShazzaKelly Member Posts: 909
    edited May 2019

    Theresa The trial drug I was on was Oraxol. It’s the oral form of paclitaxol. It seems to be as effective and certainly has less side effects than iv taxol. I’m currently on Letrazole and have been for about 18 months. Scan results tomorrow to decide if I stay on it.

  • snooky1954
    snooky1954 Member Posts: 883
    edited May 2019

    Lily....I was offered the choice of Zeloda or Taxol because one breast tumor was going outside my breast to give me skin cancer. Wanting to avoid the chance of ulceration the ONC offered the following The tx was to be for just 3mos at 3on/1off.  ( I also have bone mets and a multiple small lung nodules, and cancer in the axillary node)  I was told after three mos.  I was to back on an anti-hormonal.

    Well, at my three mo. scans I had fairly good results.   The skin cancer is still there but no more spreading. My breast tumor is less than half it's original size and the same for the axillary node tumor.  MOST of my lung nodules have been resolved and the rest are considerably smaller.  

    Good news huh?    Well, there's a twist.  Taxol did nothing for my bone mets.  THe one's I had grew and there are now a couple new spots.  My ONC said chemo mostly does nothing for bone mets and wants me to see what radiation will do for me.

    Oh, and the other thing which makes me upset (even though I know it's prob. for the best)  My ONC refuses to honor the 3mos only,  He keeps siting Standard of Care, if a treatment is working you stayon it.    The thing is the taxol has given me severe depression.  I've been on Zoloft for this for over 20 yrs,  but this depression was different.  Deep, dark, unrelenting.  I didn't even care of trying the tricks I've learned to help myself.  Dying didn't seem that bad a deal. (not suicidal, Faith way too strong for that)

    Told ONC I could not stay on taxol   So he offered me a deal for 2/3mos (Gosh, I hate deals)    First, cut back on steroids because they''ve been known to cause depression. Second, he offered to cut dose by 20%.   Third he offered for me to try every other week chemo.   

    So, I chose cutting the steroids, and every other week chemo.   He also put me on Trazodone, which is an anti-depressant but, in small doses helps you to sleep.  I was waking  up with panic attacks.  And I hadn't done that in years.   

    Sorry for the long answer.  I talked way more than what you asked about Tily.   My excuse is chemo this am. Steriod high, and who else is up at 3am? to talk with.

    But, time to go try to get some sleep.  MRI scheduled for tomorrow. 




  • Lily55
    Lily55 Member Posts: 3,534
    edited May 2019

    How did your MRI go Snooky?

  • snooky1954
    snooky1954 Member Posts: 883
    edited May 2019

    Thanks for asking Lily, the session itself went well. I had it at a different treatment center and it was a totally different experience.  Very much easier.  Tomorrow, I go in and find out what the results are.  Luckily,, I don't have to wait for results.   HUGS

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