Time before metastasis in hormonesensitive breast cancer

Hi, my mum was diagnosed in december 2008 as a stage I er- pr++ her2- ki67 15%

Her mets were diagnosed in november 2014 er++ pr- her2++ (IHC) her2- (fish) ki67 25%

Another biopsy in october 2018 er+++ pr- her2++ (IHC) her2- (fish) ki67 25%

Diagnosed 2001 as stage 2a - er+, pr+

MBC 2016 (almost 2017) - same

But, just want to caution about making comparisons at that level. So much depends on the aggressiveness, patient age, stage and treatment in addition to hormone sensitivity. I’m sorry that you are facing this nd sincerely hope the liver lesions are non-malignant.

8 years. I went from Stage 2 to Stage 4 with extensive bone mets and liver mets. ER+/PR+. Mine was likely triggered by IVF/pregnancy.

Four years for me.

But my Mom had sixteen years, then a local recurrence (she had a mastectomy this time). It's been seven more years with no problems.

Anna33,

I was originally diagnosed in May 2013 as stage IIB. I was diagnosed stage IV December 2018. I had 5.5 years in between. I was ER 90% and PR40% HER2 neg. This time I’m still highly ER positive but PR neg(still HER2 neg). I don’t know the % of ER this time. From my understanding it’s hard with bone biopsies so maybe eventually I’ll find out I’m still PR positive.

I can’t answer your question about PR sensitivity. I’m not sure but would also like to know.

JFL, do you think you would still be early stage if not for the IVF/pregnancy? Or do you think it was always going to come back? I ask because I took a break from Fareston (serm like tamoxifen) in 2017 to try IVF with our frozen embryos and I feel as if I caused my early cancer to become stage IV

this thread is so helpful and interesting to read!

I was dx’ed de novo in April 2017 and one of my biggest questions that will forever remain a mystery unless science catches up is I want to know how long was this cancer active and growing inside of me? Inside my breast? Inside my bones? Was it 3 years? 5 years? 10? 20? I wish science could answer this question.

I feel like there’s things in my life that I can look back on and ponder if they were influenced somehow by cancer growing in my body.

Thanks to everyone who has shared

JFL- I’m sorry. I know the feeling of desperation for a child. I too was given medical clearance. The IVF clinic I went to is the largest practice in the country but they are a factory. I assumed that the largest equated to the best. I learned it doesn’t. I wanted to natural cycle IVF and was told it doesn’t work and not be scared of the estrogen injections because if I was cleared for pregnancy then the estradiol valerate shots were much lower than estrogen naturally occurring in pregnancy.

I had 5 frozen embryos. 3 did not survive the thaw. The first transfer did not work. Then they recommended a uterine lining test. You go through an entire IVF cycle except on your transfer day you do the biopsy instead of the transfer. The IVF clinic lost my biopsy specimen. Then they had me go through an entire new IVF cycle so we could do the biopsy again. Finally after that we tried for our last remaining embryo. It took but I had a miscarriage. The clinic never took the time to follow up with me.

At the end of last year in 2018 Iwas going to try again but using my eggs post chemo at a different clinic. They do low dose stim cycles and natural IVF. They ran several tests on me then told me chemo had cooked my eggs and donor eggs were the only option. I started looking into adoption then three weeks later I got the news I was stage IV.

I try not to look back but I can’t help but feel like I should have never attempted IVF. I feel like I have greatly shortened my time with my son I adore. I should have protected what I had but the maternal pull is so strong.