Alisertib

Ann,

What is the NCI number for the trial? Are they combining it with another treatment?

Jennifer

Hi Ann,

Oh, I am very interested in this trial! Please post any information you learn about the results they are having with the trial thus far? Can you comment on how it was that you were recommended for this trial? Was there something from the genetic testing of your cancer that indicated that this might be successful? You are ER+PR-HER2- but may have been on aromatase inhibitor when you got mets? If so, they may be concerned about endocrine resistance.

Endocrine-resistant cancers often have PI3K activating mutations, but the drugs have not been as effective as hoped. However, earlier this year it was reported that PI3K or mTOR inhibitors, like everolimus, work synergistically with aurora A kinase inhibitors, like Alisertib, and are very effective at killing cancer.

https://cen.acs.org/pharmaceuticals/drug-discovery...

But there are significant side effects coming from the PI3K inhibitors, and we don't have a good idea on what side effects come from the Alisertib- so any information is much appreciated!!

Another combination that might work in future for this is CDK7 inhibitor with PI3K inhibitor, which could be a good combo to keep an eye on for after Alisertib..

Best of luck!

Hi Cure-ious greetings from the UK, I’m so happy to have found this intelligent thread, the posts are so informative and it’s lovely to find others so invested in treatments. I’m not medically trained but educated to degree level and find that I can understand and interpret research papers, trials etc fairly well.

I’m in the process of asking for a referral to another hospital as I feel mine has let me down in many ways. I always visit my Onc with a list of questions and ask about new drugs coming up and she shrugs and then tells me “I read too much” how patronising is that!

My primary was 1999 Er+ Pr+ Her - diagnosed bone mets 2014 Er+ Pr- Her- 8/8 estrogen

I had one CT scan 2014 and then an MRI every 12 months I didn’t question this. My last MRI in July showed progression in spine so was given another CT which showed small spot on liver. I have been stable on Exemestane for over 3 years but somewhere between the last 2 MRI scans there was progression and had I had more frequent scans this surely would have shown up sooner.

Our NHS system is a postcode (zip code) lottery and funding varies, I have had a good run on Exemestane and am keen to keep on hormonals. My Onc can only offer chemo. I had tamoxifen after primary for 5 years followed by letrezole for a further 5 years. I asked for Faslodex but not funded. I have found another hospital about an hour away that offers Faslodex so have asked for a referral there. I so want an Onc who is forward thinking and positive.

I have a question... do you think it’s possible from the CT scan to be sure the “spot” is metastases? I know it’s likely given I already have it in my bones. Onc said it might be too small to biopsy or difficult to reach? It’s 1.6cm.

Can I ask what treatment you have been on so far for your bone Mets?

Thank you

Debs