Breast cancer spreading because of biopsy?
I have a strong family history of breast cancer but i have tested brca1 and 2 neg. That was 22 yrs ago. I have a .9 spiculated lobulated mass with microcalcifications. Sering a surgeon july 31. I've been a mammo tech for 16 years. I work for a breast oncology surgeon now. His nurse has told me that breast cancer cant spread during biopsy or surgery. I had always thought before she told me that it could. I just read a post that says the person had microinvasion because of biopsy. So which is it? I need to know before I see the surgeon. I have to be off blood thinners so im hoping for open incision with frozen section and check the sentinal node at the same time. And bmx then if the surgeon will or go back while i'm still off blood thinners and do it. Any info greatly appreciated!
Comments
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This is what I found on the topic, "There's little reason to worry that a biopsy or other surgical procedure will allow cancer cells to escape and spread within the body, specialists say.
"A common patient concern is that biopsies may cause microscopic cells from cancers to metastasize to other parts of the body," says Thanh Barbie, MD, a breast surgeon in the Susan F. Smith Center for Women's Cancers at Dana-Farber. "However, medical evidence supports that this is unlikely, as most cancer cells that get displaced into the surrounding environment will likely be cleared by the surrounding immune cells."
In fact, a study of more than 2,000 patients carried out by Mayo Clinic scientists dispelled the myth that cancer biopsies cause disease to spread. The researchers showed that patients who have biopsy procedures to confirm their diagnosis and determine the cancer's stage had a better outcome and longer survival than patients who did not have a biopsy. http://blog.dana-farber.org/insight/2017/05/can-a-...
As a side note, Thanh Barbie was my breast surgeon at Dana Farber.
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Yes, it is believed that it can be spread (and/or its spreading tendency promoted) by those procedures. This is why the disease sometimes shows up again at or along one's skin incision. This is why the needle track site (from a biopsy having had cancerous tissue finding) would be taken in treatment surgery. This is why re-excision is done using the same incision line used before.
https://www.cancertreatmentwatch.org/general/biopsies.shtml
On another hand, it is believed that a single gram (so this would be per gram, what follows) of cancerous tumor tissue might shed three million circulating tumor cells (CTCs) per day. It is also believed that metastasis may occur very early on in the development of (primary) invasive tumors -- even before a primary tumor is capable of detection by any of the usual medical imaging means.
https://www.newyorker.com/magazine/2017/09/11/cancers-invasion-equation
I had excisional biopsy instead of needle biopsy. As with lumpectomies, the need for additional surgery because of diseased margins is not at all unusual -- about twenty percent of all lumpectomies for breast cancer, I think, but with my cancer type, about twenty-five percent, I think. Not all of my margins were "clean," and for the next two weeks, the very fragile tumor tissue remaining was presumably being eroded by blood sloshing against it (I could hear it sloshing) in that blood-filled cavity, presumably putting a veritable soup of it into my bloodstream.
There is a medicine that can be administered in connection with surgeries for breast cancer patients that is believed to reduce the likelihood of cancer spread from surgery. It is an NSAID. Ask your Surgeon if Ketorolac would be appropriate for your case. I am not on anticoagulant therapy, but I have long been on the highest permissible human dosing for the NSAID I take. Ketorolac was administered in connection with my last breast surgery, and I had a great deal of apparent internal bleeding -- there was a long-lasting, broad (about 7" from top to bottom), apparently fluid-congested, purple band (of apparent internal bleeding throughout) across my chest.
https://www.medscape.com/viewarticle/723293
Consider that for some of the more aggressive breast cancers, other (neoadjuvant) treatment is advisable before having treatment surgery.I understand sentinel nodes are identified from the flow of injected substance. Be aware that in some cases, no particular lymph node/s can be identified as the sentinel node/s.
Now there have been identified many more hereditable gene mutations associated with familial cancer patterns. Whether or not there is a finding of breast cancer in your case, you might wish to have full (or fuller) panel testing, because the results may matter as to your (even risk-reducing) treatment options and choices.
I am so sorry about your having this anxious time and situation.
(((Hugs)))
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Thank you both! Its hard for me to believe it can't spread thst way. If you can get an infection in your blood during invasive procedures..bacteria entering the blood stream.. why csnt cancer cells enter as well. Pretty sad it was an rn thats been in this exact profession..working for the same surgeon..for 20 years! Geez! I will check out the link you provided. My entire career i have heard that and my jaw almost hit the floor when she told me that. I need to do some more research for myself. Im going to request more gene testing since as of now it was my mom at 39, sister at 39, prob me at 52 and my brother schd for a prostate bx.. psa over 6 at 64. Wishing you both the best!
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I am a firm believer that any inflammation can be a cause for cancer to spread and grow, including the inflammation caused by the biopsy. I wanted an excisional biopsy but was not able to find a breast surgeon willing to do it. Most breast surgeons require a needle core biopsy. I did not have lymph node involvement prior to my biopsy, it was not palpable or visible with ultrasound. Nine days after my needle core biopsies (I did have bilateral cancer and they did 2 needle core biopsies of 5 and 6 passes, each breast) there was lymph node involvement. It grew to 2.6cm it just 9 days and burst the lymph node. Perhaps it was there prior to the biopsy but too small to identify, but something caused it to grow to 2.6cm in 9 days. I believe it was the biopsy and inflammation. Insist on the ketorolac preincision, I do now for all surgeries and if my surgeon refuses, I find a new surgeon.
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A breast biopsy is known to carry a small risk of spreading cancer cells through the breast. It is called needle track seeding, neoplastic seeding... it can be called a few things in the literature. Anyway, here is a recent article on it: https://link.springer.com/article/10.1007%2Fs10549-017-4401-7
I was one of the "lucky" ones to have this happen. My MO and BS confirmed that yes, it happens, and it is probably the best explanation for my skin metastasis. However - and I can't emphasize this enough - don't let that scare you away from a biopsy.
If you are worried about it, here are a few things you can consider:
1.) Some types of breast biopsies are a higher risk for needle seeding than others - talk to your BS and inquire about whether a lower risk biopsy is possible.
2.) If you later have a lumpectomy/mastectomy, one possible solution is to surgically remove the needle biopsy path and surrounding skin with the tumor specimen. This is not always routinely done, as it is deemed unnecessary, and can have a worse cosmetic result. However, if you have a very aggressive cancer, these are good extra precautions to take. This was not done for me, but I think it might have prevented my current situation.
3.) Even though needle seeding can occur in breast biopsies, a few stray cancer cells *should* die from inadequate blood supply, radiation, chemo, etc. That is why you need to follow through with all your recommended treatment.
4.) Cancer can be spread by surgery, as others have pointed out. However, surgery is still the most important part of treatment for early stage breast cancer, and gives us the largest survival benefit.
Anyway, my situation was double bad luck: I was unlucky to have needle seeding at all, and unlucky because my cancer was super aggressive and the stray cells that were spread in the biopsy refused to die from standard treatment! Instead, my cancer actually GREW during radiation and dose dense AC chemo. So yes... It happened to me, it made a mess, and now I have to live with the consequences. But as the article points out, it is rare for it to happen in the first place, and it is usually only a problem for those of us with very aggressive cancers. Most people are not in that situation.
That being said, I wish they would change protocol and do more to prevent this. For those of us who are more at risk, the consequences are life threatening. Even though it's rare, it happens too often.
Anyway, it's good to be informed, but also be realistic about the risk. It's small. It is much riskier not to biopsy and treat a possible cancer. I hope that helps, and that you find some good solutions going forward. Please keep us posted.
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All your personal history and information just insures me of my decision. The one i made 16 years ago only months into my career as a mammographer is still right for me today. It's really nerve wracking meeting doctors for the first time.. at least the ones that will be treating me personally. I hope this surgeon will give me my options but respect my wishes. Im not the average patient that doesn't know at least some of what's suppose to happen. And its so very true..its different when its you! Thank you so much! Im sorry you're going through this at such a young age! Prayers for you!
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I think if I were you, I would stick with MDAnderson and the American breast cancer findings. If your test is positive Nothing will make it worse. You can only get better. There are so many variables for each person's diagnosis it's hard to compare. Speculation without the details of your diagnosis can drive you mad. If you want every detail of every form of breast cancer and it's treatment and clinicals about to hit the patient scene MD Anderson is for you. It also helps with what questions to ask your doctors. Your doctor will listen to your wishes unless he feels you're doing yourself harm. If not find another. Mine gave me an array of choices but all hinged on my tumor. You'll still have weeks to wait on some of the path but you'll know your disease and choices you have. If you second guess the standard of treatment today then all the research, testing and studies with women in your position is of no availe for you. Hugs and strength to you. I would be interested I your diagnosis-hopefully negative. Be sure to check out After The Shock forum if your interested in additional communication with women at every leg of this journey. :-)
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I had the same concerns. In very rare cases seeding along the needle track does happen. Usually the body destroys these cells. I wanted an excisional biopsy for my latest mass but no breast surgeon in Ontario would do one without a core biopsy first.
I believe it is difficult to find a breast surgeon anywhere who will immediately do an excisional biopsy without a needle or core needle biopsy first. And even if an excisional biopsy is done, they often need to go back later to clean up the margins, so you may still have cancer cells released into the body between those two surgeries.
Once cancer is in your body there is a chance that there are already cancer cells floating around in your blood and lymph fluid, way before a tumor is discovered. Most of these cells the body will destroy, and those that are left, that is what systemic chemo is for.
Core and needle biopsies are the standard operating procedure. Think of the millions that have been done. If having a biopsy was a deadly mistake with bad outcomes, I don't they they would be the standard of care.
I know I read of at least one study assessing this issue, in which they found that yes some errant cells were released into the body after biopsy, but the number of these cells DECLINED as the interval between the biopsy and detecting the cells increased. This showed the body was successfully destroying the cells. I will try to find that study and post the link.
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The article I posted above was out of MD Anderson, and they found that of 4,010 cases there were 8 cases of seeding from a breast biopsy. (This study does not address distant proliferation of cancer cells at all, only local spread within the breast.)
Anyway, according to those numbers you would have around a 0.2% chance of this happening. I just happened to be one of the 0.2%, and I had the risk factors they identified. In any case, that is an extremely low percentage. I hope that helps to reassure you. It's good to be aware and vigilant with this disease, but at the same time you will drive yourself crazy if you worry about every possible complication.
In many ways breast cancer is still on the fringes of our understanding. Although the standard of care isn't always perfect, I remind myself that it's still the best we have right now. Maybe one day there will be a real cure, but we're not quite there yet.
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One of the problems in proving whether or not biopsy/surgery spreads the cancer is this statistic:
(from the Providence Health & Services, Oregon web site)
"With most breast cancers, each division takes one to two months, so by the time you can feel a cancerous lump, the cancer has been in your body for two to five years. It can certainly seem like a lump appeared out of nowhere – especially if you or your doctor have recently examined your breasts and not felt anything suspicious – but in reality, the cancer has simply doubled that one last time necessary to be noticeable. By the time you can feel it, a breast tumor is usually a little more than one-half inch in size – about a third the size of a golf ball. It has also been in your body long enough to have had a chance to spread."
There are millions/billions of cells in that tumor as well, many of which may be carried distantly before its discovered
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I was told that this is very possible but that most doctors will not admit this to patients. They may fear that patients will be afraid to have biopsies, which are obviously necessary. My sister's doctor does surgical biopsies for this reason. I asked lots of questions because I was curious as to how my lazy little grade 1 tumor managed to make it into my first sentinel node of 8. I had both types of biopsies on the same date. They did the needle type and also the stereotactic type on the same area, several samples from each. Needless to say, I was quite a mess, black and blue over almost the entire area of my 34B boob. My doctor did tell me that they think some of these cases of node isolated tumor cells and micromets may not be true mets but instead just the nodes doing their job picking up residue from the biopsies. Interested in what others think about this. Of course, in my case the micromets may have had more to do with my type of cancer which was IDC with Lobular Features. Studies show that almost 50% of these cancers have spread to the first sentinel node for some unknown reason.
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There's alot to consider..does it or doesn't it! There's still so much unknown about breast cancer. But also so much progress since my mom's dx in the 70's (mastectomy and cobalt radiation that burned her skin to her sternum) and even more since my sisters dx in the 90's. Since I've been reading and reporting to radiologists for 16 years I've had the opportunity to see lots of patients charts and all that it contains. My mind is made up as to what surgery/treatment is right for me and I'm praying this surgeon is one that will really consider what i want. I don't care what any dr says...it should be the womans choice as to whether its lumpectomy, umx, or bmx. I've had a few patients thst were discouraged and pressured into not having the surgical trestment they wanted and it ended up killing them in less than 2 years. I'll go to my appt with an open mind and lots of prayers! And go from there! I appreciate all your responses and wishing you all the best!
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My tumor/nodule/mass is 1.5 cm. I will have the results of my stereostatic biopsy tomorrow. My mom had TNBC dx at age 75. I am 56. Truly hoping I'm not TNBC. My mammo was painful, but nothing compared to the biopsy.Worrying the cancer may be really mean with all this pain. The lump is the size of a pea and looked like a perfect pea on the mammo.
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I'm sorry this is happening to you. With your mom's hx I'm sure you're beyond scared! 1.5 cm is not considered very big. Sounds like if it does turn out to be something its early. Mine is .9 cm and hearing its so small helps but it still keeps me up at night. And if you mean smooth borders by perfect pea..smooth borders are also good! We do sterotactic bxs where i work and geez i never want one! Alot of docs are in a hurry and won't take the time to numb you up good. It's awful sometimes. Praying your bx comes back negative!
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That site you posted is amazing, thank you so much for posting it. I believed my cancer was spread to the lymph nodes through the biopsy, and this is just more evidence. Kinda scary to think though, that the current expected level of care is actually promoting cancer. I hope they continue their study and change the way cancer is treated. People use to think years ago just opening someone up that has cancer would spread it. I remember hearing people saying once air hits the cancer cells it spreads like wildfire, and there is somewhat a bit of truth to that, although, not the air that causes the proliferation, but the dislocation of cells entering the bloodstream and lymph system.
The downside is you must be treated or it spreads anyways. It might have spread even before the biopsy, so if we need a biopsy to be treated currently, then my suggestions is to do everything you can to make sure those tiny cells are not in an environment that is hospitable and allows them to grow. Ketorolac for inflammation and change of diet ( high protien, low carb, no sugar), radiation for the stray cells and chemo for those that escaped.
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