ER/PR +

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Deamo1
Deamo1 Member Posts: 193

My ER/PR was very high 93 and 98. Does having a high ER/PR have anything to do with female hormones? Trying to understand the difference. Thanks

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  • Polly413
    Polly413 Member Posts: 124
    edited July 2018

    Yes. This means estrogen and progestin cause your tumor to grow. There is nothing lucky about breast cancer but my breast cancer surgeon was very happy to see I was highly estrogen and progestin positive because there are therapies targeted to that -- i.e. they reduce the effect of these hormones in your body and usually for that reason your prognosis is better when your BC is both ER/PR positive. In my case because I am 73 I was very surprised to have this type of BC because I already had all the evidence of low estrogen most older women have such as dry skin and thinning hair,etc prior to breast cancer and it hardly seems fair! Polly

  • Deamo1
    Deamo1 Member Posts: 193
    edited July 2018

    Thank you! Wonder why my Oncologist didn't want to check my hormones also. I'm going to have my gyno do it for sure.

  • SpecialK
    SpecialK Member Posts: 16,486
    edited July 2018

    The percentages given do not reflect circulating estrogen, rather they are a measure of the number of receptors on the breast cells. The lab has a slide with 100 breast cells and then counts the number that have receptors - this is what makes up the percentage - an example would be the OP’s 93 - this means that 93 out of the 100 has an estrogen receptor. The importance of this is that a high number of receptors are ready to receive any circulating estrogen that is available. The only reason for an oncologist to check hormone levels wouldn’t be to determine whether a patient is pre or post menopausal, if there is any uncertainty, to determine which type of anti-hormonal is appropriate to prescribe

  • Lula73
    Lula73 Member Posts: 1,824
    edited July 2018

    ER+ means there are estrogen receptors on your tumor cells and the estrogen feeds/fuels the cell growth and division. This is considered a good thing because there are hormone blockers and inhibitors that can work to help reduce recurrence risk by starving the cells of its fuel. The higher the percentage given, the more dependent on the estrogen the cells are. PR+ Means there are progesterone receptors on the cancer cells. It's often assumed that this has the same meaning as estrogen+ but just a different hormone fueling the tumor. However, Its just the opposite. When the PR your body makes interacts with the receptors it actually interrupts the DNA signaling in the cancer cells and slows its growth. Bio-identical PR seems to have the same effect and is often used as treatment for stage IV ER/PR+ BC. Synthetic PR often found in prescription/nonprescription pills (like birth control pills) and creams is different than the PR our body makes and can increase risk of recurrence and is not recommended. Here’s a good visual on how all this works:

    image

    When you're PR+ anti-hormonal therapy will be recommended. They will only test your hormones to see if you're pre or post menopausal as those results dictate which anti-hormonals you can take. Unless you're post menopausal, routine hormone testing is useless as estrogen will still be present at significant levels in the blood stream-it just won't be able to interact properly with the receptors on the cells. The receptors being +/- have nothing to do with how much hormone you have circulating in your body.

    Hope this helps!

  • Deamo1
    Deamo1 Member Posts: 193
    edited July 2018

    Best explanation ever! Thank you!

    Now another question. I took the Mammaprint test and it showed (less than) 10% reoccurrence without any hormonal or chemo therapy. What if I don't take hormonal therapy? Knowing my ER/PR was 98. I'm deciding if I need it. I'm leaning towards not taking hormonal right now. Thoughts?

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