Best time to take Ibrance and Letrozole

Hi. I take Ibrance/Letrozole in the morning with my cereal. I read that Ibrance absorbs better when taken with food and breakfast is my most consistent meal.

I am cycle 19 and my liver mets are behaving!

hi friends!

Lynnewood I love that you are on cycle 38 and stable!!! Gives me hope!!

I am on cycle 13 (?? Wow!!!) and I take my letrozole first thing when I wake up and then I take my Ibrance with breakfast about an hour or two later.

At first I felt all types of things like nausea, heartburn, anxiety...but now I don't have any stomach issues. I wonder if it was all in my head??? I get an occasional upset belly like 1/2 through the cycle or sometimes towards day 21 but nothing too intense.

Key things: avoid grapefruit and I was told by my ND also pomegranate, curcumin, goldenseal and I researched that bergamot (key ingredient in earl Grey tea) should be avoided as bergamot is the essential volatile oil from a certain kind of orange that is a no-no.

All the best! Brend

I think ND is a naturopathic doctor, but don't quote me on this.

I take my letrozole with lunch and Ibrance with dinner. I think some people mentioned trouble sleeping/bad dreams taking letrozole close to bed, so I decided to take it with lunch. I take Ibrance with dinner because it's my biggest meal and it's supposed to be taken with food with some fat in it.

I also wanted to spread out my daily pills and supplements so I don't whack my GI with 12 different pills at once (I take a baby aspirin and fish oil, calcium and vitamin D, a probiotic and an antihistamine in addition to the letrozole and ibrance).

It won't make a difference whether you take them together - the half-life (time it takes for the blood concentration to be cut in half) of letrozole is 2 days and that of Ibrance is 27 hours, so there will be plenty of each drug in your blood at any given time. Take them whenever it's most convenient and gives you the least trouble.

I have been dealing with Stage IV to my bones and have been taking Ibrance and letrosole for the past 2.5 years. It has keep me stable and doing well. I wanted to quickly share what my research has led to additional improvements. I have been taking 1tsp of Dried Ginger /day after reading research showing The active ingredient in "Dried" ginger kills 10,000 time more cancer stem cells than chemotherapy alone. Since adding Dried ginger to my daily diet as tea or Capsules my tumor makers went down much more than on Ibrance and Letrosole alone, and have stayed down. This is the title of one of the articles I read (or skip to the Summery if too complicated) Found articles in Google Scholar.like : 6‐Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase‐9 expression via blockade of nuclear factor‐κB activation. I also take Curcumin (Anti inflamitory) which with the medications has decreased my pain from 10/10 in my hip to 0/10 within one month after diagnosis. A good resource i recently discovered is a DR who operates a non profit dealing nutrition for healing and fighting diseases. His site is called NutritionFacts.org. Also you should look into IP6 (inositol hexaphosphate) To reduce chemotherapy side effects (small study), it suppose to improve quality of life. Please do your own research but I thought of sharing what took us about 2 years to find out these resources. Hope this helps Pat