Arimidex - cause of high blood sugar?

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Lee64
Lee64 Member Posts: 184

Had my 2nd 4-mo. check up yesterday. My blood sugar was l77!  In Nov. it was l22. I started Arimidex in Sept. and always had normal glucose levels before. Has this happened to anyone else? I have no history of diabetes in my family and never had this problem before. Thanks for any input.

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  • dogsandjogs
    dogsandjogs Member Posts: 1,907
    edited March 2012

    I don't know about sugar, but my cholesterol is high since being on Aromasin. It has always been on the low side before this.

    Do you have increased appetite for sweets? That can happen too--

  • Lee64
    Lee64 Member Posts: 184
    edited March 2012

    Thanks, dogsandjogs, for the reply. I  really don't like sweets at all; maybe have a dessert a couple times a year. I don't know if my cholesterol was checked during chemo. I have to make an appointment to see my PCP and I am just dreading another doctor appt.

  • IllinoisNancy
    IllinoisNancy Member Posts: 722
    edited March 2012

    Hi,

    My blood sugar went up with Arimidex too.  I found out when I had stomach flu and they did a blood test.  I guess I will see what the Onc thinks about that next month.  I am just so sick of doctors and medicines that I try to ignore it since I feel fine.  Good luck!

    Take care,

    Nancy

  • jancie
    jancie Member Posts: 2,631
    edited March 2012

    My blood sugar went up on Arimidex and I was pretty much on a low sugar diet - monitoring the grams of sugar per day - reading labels, etc.

    My cholesterol levels also increased.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited August 2012

    Add me to the list  After 4 1/2 years - my fasting blood glucose went up about 10 points a year.  THEN, it rocketed about 20 points, which I attributed to all the NIACIN I was taking to try to get my cholesteral levels down.

     Well, the cholesteral did drop by a large amount. BUT, then I read that taking large amounts of Niacin could contribute to a rise in blood sugar.

    DAMN.  Sorry, but I feel like being caught between the proverbial BRICK and a hard place.  SO, I'm taking LOTS of cinnamon, alpha lipoic acid, cutting all high glycemic carbs ( I've been gluten free for years, so very few carbs anyhow) and my blood glucose is dropping.

    ALL THAT BEING SAID- I THINK ARIMIDEX CONTRIBUTES TO HIGH BLOOD SUGAR - and with all the other hideous SE's we have to deal with( being on what I call the A Team) the docs just haven't worked their way to learning about blod sugar, YET!!!!

  • bevin
    bevin Member Posts: 1,902
    edited March 2012

    I too have had my blood sugar increase on arimidex. I was normal my whole life - about 80 glucose level and now its 100. My diet and excercise regime have not changed.

    Interesting question- did you chat with your Onco about it. I'm about 2 years out from diagnosis and at my next appointment will ask.

    If your level is about 120 you'll want to chat with the doctor to ensure you dont have diabetes. They should do a fasting blood glucose level on you. Do you fast before your blood tests.  I don't eat before as that will increase blood sugar in our bodies.

    Keep us posted on your update.

    Bevin

  • bevin
    bevin Member Posts: 1,902
    edited March 2012

    I too have had my blood sugar increase on arimidex. I was normal my whole life - about 80 glucose level and now its 100. My diet and excercise regime have not changed.

    Interesting question- did you chat with your Onco about it. I'm about 2 years out from diagnosis and at my next appointment will ask.

    If your level is about 120 you'll want to chat with the doctor to ensure you dont have diabetes. They should do a fasting blood glucose level on you. Do you fast before your blood tests.  I don't eat before as that will increase blood sugar in our bodies.

    Keep us posted on your update.

    Bevin

  • financegirl
    financegirl Member Posts: 114
    edited March 2012

    Onc said I'd be having regular blood tests (b/c of the Arimidex I'm taking).   Just asked nurse this when I had my last chemo port flush and she took blood at that time and she said she thought she's heard the doctors say it affects blood sugar and cholestrol.  So, I'm guessing it's what you all may be presently seeing. 

  • Anonymous
    Anonymous Member Posts: 1,376
    edited August 2012

    Blood tests.  Hope you all know that the Fasting ( 12 hour) Blood Glucose test is just a "snap picture" and if you are over 100 on that test, you SHOULD ASK FOR AN A1C blood test.

    The A1C( some call it an hbA1C) is a blood test that goes back 3 months and shows the level of glucose in the body NORMAL on this test is 5.6 or below.  Prediabetic is 5.7 to 6.4%

    On the Fasting Blood Glucose test below 100mg/dl is considered fine.  From 100 to 125 is considered prediabetic.

    I bought one of those little home testing thingies - and my numbers are ALL OVER the lot during different times of the day. The only thing I am sure of, is that Arimidex DOES effect the blood sugar levels.  Now waiting for oncologists to catch up on what WE KNOW Wink

  • Anonymous
    Anonymous Member Posts: 1,376
    edited August 2012

    I've been blaming Arimidex - wonder how many other women are taking Glucosamine or Chondroitin to ease joint pain????

    http://www.glucosamine.cc/Chondroitin_Glucosamine_Side_Effects.htm
    Chondroitin glucosamine side effects: insulin resistance 
If you suffer from insulin resistance or diabetes, or are at risk of developing insulin resistance, you may experience serious chondroitin glucosamine side effects, because glucosamine is believed to affect insulin resistance in humans. There are currently no clinical trials with human participants to back this theory, but animal testing has showed that there might be a link between glucosamine and insuline resistance - at least for certain animals.
    Until we know more, chondroitin glucosamine should be used with caution by those who suffer from insulin resistance or diabetes, or are at risk of developing insulin resistance. Consult your doctor before you start using chondroitin glucosamine. One way of avoiding potential chondroitin glucosamine side effects is to have your blood sugar checked regularly. Insulin resistance is serious, because it increases the risk of developing type 2 diabetes and metabolic  syndrome.
     

    DAMN, JUST DAMN - I was blaming the Slo-Niacin ( which helped lower my sky high cholesteral) but also probably has same effect on some 10% of takers as the Statins.  NOW THIS.

    Brick - rock - hard wall.

  • wallycat
    wallycat Member Posts: 3,227
    edited April 2012

    Since my 40's my glucose started hovering in the 102 fasting. I lost weight and added low-carbing and itkept it normal. Since arimidex, I added herbs and my fasting was actually 100 this time.

     Just a reminder that the 100 as pre-diabetes has only been "approved" the last several years.

    When I went to dietetic school, the fasting was 110 (this is still the normal fasting limit in Europe) and 100 was reserved for pregnant women.

    I can't wait to see what happens after arimidex.  I suppose if this is due to low estrogen, at some point, those of us predisposed, will end up with the same issues.  

    Damn is a very good exclamation!

    Editing to add: the only bright side to this is that the drug of choice is metformin, which is in clinical trials to reduce risk of breast cancer/recurrence.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited August 2012

    wallycat

    I got an email response from my question from my doc at Dana Farber - and it's not, honestly, as far as they know, the Arimidex.

    I fimrly believe it's the OTHER stuff:  cholesteral drugs, which we now KNOW.  I was taking Slo-Niacin, but it acts just like the statins do - really helped reduce my cholesteral, BUT..up went the blood sugar.

    What herbs did you take?  I am taking masses of cinnamon, also using alpha lipoic with my supplements, and lots of green tea.  

    Have stopped ALL glucosamine, chondroitin....

    but will try ANYTHING....my fasting goes from 95 up to 125 on some days....strange...

    eta: wally - I was excited too thinking about metaformin, until I looked up THOSE Se's - 

    DAMN!

  • wallycat
    wallycat Member Posts: 3,227
    edited April 2012

    I personally think that some of us are predisposed (genetically/heredity) to get some of these chronic, age-onset type "conditions" because our bodies react to the lack of estrogen as if we are aging unnaturally.  Of course, I would much rather deal with some of this stuff in my 70s (and hope I live that long) rather than in my 50s. Ah well.

     I don't OD on cinnamin but if I think of it, I sprinkle it on things I will eat.

    Green Tea supplements have shown to cause some liver issues, so I stay away from that as well.

    I take a multi that contains alpha-lipoic acid, grape seed extract, and a bunch of other stuff.

    I also take bitter melon (supposed to be good for glucose and cancer).

    I take L-taurine for blood pressure, magnesium (up to 1000mg or so broken up am/pm), a potassium supplement (99mg)..i started this with the tamoxifen because of the horrible leg cramps at night. I also take hawthorne for blood pressure.  I take about 7000IU of vit. D and I take milk thistle (standardized)--it is supposed to help lower glucose but I also think it helps cleanse out my poor liver of any effects from the meds.  I take a full aspirin at night with all of these.

    The once/day is really a twice/day but I only take it once..it also has coq10, resveratrol and L-carnitine. 

  • Anonymous
    Anonymous Member Posts: 1,376
    edited August 2012

    wallycat - you sound like me!  Only I'm older.  I take most of that stuff.

    My "blood sugar support" has bitter melon in it.  I should go back & look at Milk Thistle, I remember not taking it cuz I had gallstones, but had gall bladder removed, so now can probably take it..

    Agree with the genetics - and think taking an AI contributes to it too...

  • dopbell
    dopbell Member Posts: 2
    edited September 2017

    So, I just transitioned to anastrozole (Arimidex) one month ago. I was on tamoxifen for about 2 years. I have a family history of diabetes and I'm overweight. I did 2 fasting blood sugars this week: 133 and 149. My hemoglobin A1C is 6.1. I also have polycystic ovarian syndrome and was close to getting gestastional diabetes when I was pregnant with my twins. So, all that combined......I have diabetes now.

    Sadly, I have a HUGE sweet tooth. That is what bothers me the most......that I now have to give up all those simple carbs. I have started to walk 45 minutes a day, which has helped me lose some weight. I'm hoping if I get to my ideal weight, my sugars will improve. I also have high blood pressure - and I know that I could probably get off my blood pressure meds as well if I got to my ideal body weight. It is just so hard. I have struggled with my body weight for all my adult life.

    Anyway, it is just one more thing to deal with.....

  • ChiSandy
    ChiSandy Member Posts: 12,133
    edited September 2017

    I’m on letrozole (Femara) but pretty much the same SE’s as anastrozole due to both being nonsteroidal AIs. My fasting glucose has always been in the low 90s (exception being the couple of weeks after each knee replacement surgery—stress & physical trauma’ll do that). Since starting AIs, my glucose was >100, & a1c is in the high 5s. But those were all postprandial. (a1c, though is a long-term steady value). BUT letrozole spiked my LDL & total chol. to alarming levels, raised my triglycerides a bit, and took my HDL from the 90s down to 70 (good but not great). As a result, I went on a statin (Crestor) and my lipids are back to desirable levels (HDL in the high 80s). Glucose still hovering >100, but MO & PCP not worried. Neither think I should get any antidiabetic drug (though if it ever comes to that, my PCP says Jardiance or Invokana are more cardioprotective).

    But had a semi-fasting chem panel (last ate at 1 am) this morning at 9:15 before my Prolia shot, and the results aren’t in yet.

  • Akaamy2003
    Akaamy2003 Member Posts: 12
    edited February 2018

    I've had the same experience. My blood sugar has been borderline high (110 fasting, spikes above 140 after meals) for several years. I stopped eating carbs, which controlled it until I started anastrazole. Now my fasting levels are 120-150 all the time. Because I'm on Ibrance, which causes artificially low A1c ratings, I can't get treated for diabetes -- my A1c levels are not above the level where doctors will prescribe anything. My feet burn all the time and I'm wondering whether the anastrazole is worth it.

  • dtad
    dtad Member Posts: 2,323
    edited February 2018

    Hi there. You might want to ask your doc about the drug Metformin....

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