long lasting treatment after multiple lines fail?

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ABeautifulSunset
ABeautifulSunset Member Posts: 990
edited January 2018 in Stage IV/Metastatic Breast Cancer ONLY

It seems like each of my treatment protocols works for a little less time with each one. Is this a downhill spiral? I'm wondering if it's still possible to find a long lasting treatment after four other protocols have stopped working. I don't think MO would be completely honest, as he always skews to the most positive and ideal benefit. Thanks for your input.

Stefanie

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  • ABeautifulSunset
    ABeautifulSunset Member Posts: 990
    edited January 2018

    bump.

    Really? No one

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  • bigbhome
    bigbhome Member Posts: 840
    edited January 2018

    I don't see why you couldn't. Just because one doesn't work long term, you never know what's around the corner! I mean, seriously Stephajoy, you will be one year ahead of me for a long time! Surely, you are not going to tell me that I m in trouble, because Ibrance hasn't lasted as long as Faslodax did. You will land on one that will work for a long time!

    I'm sorry I didn't respond sooner, but I feel sure you will find a long lasting treatment.

    Hugs and prayers,

    Claudia

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  • Sadiesservant
    Sadiesservant Member Posts: 1,995
    edited January 2018

    I hope that's not the case Stefanie as I have yet to find a treatment with a durable response. I feel pretty positive that we will hit the magic treatment that turns things around soon. And you haven't been on Verzenio yet. That could be a game changer.

    Pat

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  • ABeautifulSunset
    ABeautifulSunset Member Posts: 990
    edited January 2018

    thank you for the positive feedback. I’m definately hopeful

    I think I’m looking for someone to tell me they failed a couple of treatments and then got a long reprieve off of another. Anyone have that happen?

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  • SandiBeach57
    SandiBeach57 Member Posts: 1,617
    edited January 2018

    Stefajoy. I am interested in hearing these stories, too.

    I am "bumping" or responding to keep your thread active.

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  • Southernsurvivor
    Southernsurvivor Member Posts: 632
    edited January 2018

    Hi Stefanie,

    I’ve found no correlation from one type of treatment to the next on length of success. I had basically no luck with Abraxane or Gemzar/Carbo combo, then got a good 14-15 months on Xeloda. Then more failures and now on Halaven for almost 6 months so far with quite good results. I think it’s just a matter of finding the “right” one(s) for each individual, which of course, is trial and error (or what I call a crap shoot.) I haven’t had really long lasting success on any protocol yet like some have, but I’m still praying for that!

    Hang in there, Stef - as Claudia said, “you never know what’s around the corner!”

    Hugs, Sheri





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  • ABeautifulSunset
    ABeautifulSunset Member Posts: 990
    edited January 2018

    My first protocol after chemo was Faslodex and Exemestane. That lasted almost four years, so I got spoiled early. Then onto Ibrance and letrozole. That lasted almost two years. Just left Xeloda after 8 months and starting Afinitor with Faslodex, so I guess we’ll see.

    :)

    Stef

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  • JFL
    JFL Member Posts: 1,947
    edited January 2018

    Stefajoy, I can't recall who but I have seen at least two on these boards who had 3 or 4 fails and then found long-term response on something. Hopefully they will chime in.

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  • Becs511
    Becs511 Member Posts: 303
    edited January 2018

    Three treatments failed me over the course of about 2 years. I then found Xeloda (along with Herceptin and Avastin) - protocol #4. I started it in May 2016. I have been stable ever since. I do have scans next week so I hope lucky #4 is still holding down the fort!

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  • Cure-ious
    Cure-ious Member Posts: 2,626
    edited January 2018

    Thanks Becs! Of course the firstline regimen is chosen because most people respond to it and for the longest time, but they are just starting to use molecular genetics of the tumor to guide therapies, and even that is most often pretty uninformative, so for the most part it is a crapshoot.

    Steph-Immunotherapy and CAR-T protocols are the biggest game-changers, and there is a trial with Abmaciclib and Keytruda you could consider. The CAR-T trials they do at the NIH require that you have had at least one chemotherapy treatment regimen in the metastatic setting.

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  • ThunderJeff
    ThunderJeff Member Posts: 38
    edited January 2018

    Cure-ious--any idea if other comprehensive cancer centers are doing CAR-T trials? If there's something in the midwest that would be intriguing. My mother is moving on to Gem/Carbo after progressing on Xeloda/Keyruda clinical trial. If Gem/Carbo isn't efficacious, my thought is it would be better to take a shot at something in the IO space instead of another systemic therapy. (Doc said Verzenio/Ibrance wasn't high on the list at the moment because of her relatively low hormone presentation (20%PR/no ER).

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