Tamoxifen or no?

I'm not sure what you mean by "chemo prevention" as Tamoxifen is not chemotherapy, but rather an estrogen inhibitor/blocker in the breast.  That being said, my mother was diagnosed with breast cancer at 42. She passed away from metastatic breast cancer at 56. I took all the genetic testing, which came back negative. However, at 41, I was diagnosed with breast cancer. If I had taken Tamoxifen prior to my diagnosis, would that have made a difference? I don't know.....but in my opinion, if you have the opportunity to take it, I would.
Some women have horrible side effects from Tamoxifen, so you will hear all sorts of horror stories. And then some women do quite well on it. Also, be advised that Tamoxifen can cause a slight risk of uterine cancer, as it increases estrogen in the uterus and ovaries. (But decreases it in the breasts.)
Whatever you decide to do, I wish you well!! 

that is a tricky position to be in. Keeping body weight at a healthy level and exercise does help but doesn't so it all. You could research broccoli sprouts and mushroom extract. If I were in your position that is what I would pursue.there was also a study about intermittent fasting and breast cancer as well as not eating in the evening. That might be worth reading.

Also ask about a 10mg dose iof tamoxifen. I don't the research is there on chemo prevention has studits that though. It's tough to make decisions in such a gray area.

if all I needed to do was give tamoxifen a try to prevent what I'm currently dealing with I would be all over it. I'm 43 and I'm in my last crappy week of dose dense red devil so my view is but sour at the moment.

Yes its a tricky position. I have a friend who is around 47 and she had DCIS removed with radiation. For her the Tamoxifen has very little side effects. She thinks it is affecting her eyesight a bit. Your case might be a good canidate for the 10mg option. I know they were looking at the low dose for prevention. In my case I have had a chemo etc so I can't always separate the tamoxifen from the other side effects.

Another place to research this is called FORCE. It is for women who have a gene that puts them at risk for cancer. I think your way of looking at it is to conclude that you probably have a gene but they haven't found it yet. In my situation I have a gene PALB2 that is newly discovered. The research is thin so I research what they do for BRCA 1 & 2 women I look at the studies they have done for tamoxifen etc with them.

This might help answer your question. You could meet women who have a gene and are taking tamoxifen as a preventive measure or have been advised against it. An important factor is whether your relatives were ER/PR + or not . Because this is truly the only thing Tamoxifen works on. Many BRCA women are triple negative when diagnosed that is why they don't always recommend Tamoxifen.

Also my MO told me that 5 years of tamoxifen can provide up to 15 years of protection with certain BC. So you could also choose to wait awhile and then try it or try it now and if the side effects annoy you quit.

My mother and her sister were diagnosed in their early 60's in recent years. If I was made aware of my risk, despite my mothers negative genetic testing results, I would have jumped at any opportunity. I found a lump which appeared suddenly last year and within 2 weeks was diagnosed myself at stage IV with a bone met and now recently found but pre-existing brain lesions, I am only 42. I feel perfectly normal and am thankful for that but cancer is sneaky and I'd be more concerned about the family history as an indicator of future risk. Best of luck, whatever you decide.

I was told by the genetic councilor that there was likely and increased risk, perhaps in a 20 gene combination unknown at this time.

That's tough. My sis was dx'd with inflammatory breast cancer at 48. No other family history of it. Back then she tested for Brca..was negative. 48 came and went for me. I had been seeing a breast surgeon yearly for years due to dense breasts. Was like an ins policy for me to have her dbl check. For 2yrs she was able to get me an MRI then 6mths later I did mammo/sonos. Then i was not considered a high enough risk to warrant the MRI's any longer. At 51 I got hit with ILC. Pathology after surgery also showed Dcis/Lcis in the same 7mm tumor.

Had I been offered the Tamoxifen back then, I don't know what I would have done either. Unfortunately we have no idea what lies in store for us. Did they offer you increased surveillance since considered High risk? Alternating MRI with mammo/sono? At least that way you feel like if forbid anything would pop up, you would know sooner than later.

Sorry I'm not much help.

I think increased surveillance is a very good suggestions