Xeloda for residual disease for ER+ or PALLAS trial?

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Mom_of_twins
Mom_of_twins Member Posts: 180
edited April 2017 in Stage III Breast Cancer

Hi everyone! This post is sort of a spin off to my previous post, "Response to neoadjuvant chemo?" Is there anyone here that is ER+ that is currently taking Xeloda after they had significant residual disease after neoadjuvant chemo? I consulted with 5 top oncologists (Rush, Northwestern, and U of Chicago locally, as well as MSKCC and Mayo). They all consistently said that they would only consider Xeloda if I was triple negative. They all recommended the PALLAS trial (I just signed consent today), but I'd rather actually know I'm getting a drug (versus being in the control arm) that has been proven to reduce the risk of recurrence of both ER+ and ER- cancer, which the Create-X study (Xeloda) has demonstrated. The worst part of all of this is I feel like I want to do more and everything I can to keep this BC away forever. I have 4 very young girls and this is all so scary.

Would love to hear if there's anyone out there that's ER+ with residual disease that is currently taking Xeloda.

And as a side note, is there anyone currently enrolled in the PALLAS trial? If so, how's it going?

Thanks!!

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  • Miamimi
    Miamimi Member Posts: 16
    edited April 2017

    hello,

    Did you get into the Palas study? I'm on Xeloda but thinking of stoping so that I can participate in the Pallas study

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  • Mom_of_twins
    Mom_of_twins Member Posts: 180
    edited April 2017

    Yes, I did. But I landed in the control arm.

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  • KammyMN
    KammyMN Member Posts: 9
    edited April 2017

    I am in the PALLAS trial - mid 2nd cycle now. I'm not exactly certain about side effects because life has been a bit of a whirlwind. Chemo finished late October, Radiation finished mid December, ovary removal early January, started Letrozole February 1st and then PALLAS trial (I was randomized to receive the Ibrance) in March.

    Noticed thinning eyebrows/lashes, but frankly, I believe that was from the Letrozole, and they've already recovered. My finger nails seem weaker once again, I'm more tired, and my white count has taken a hit, but is currently just barely under normal levels, and while I still get exhausted by about 4 p.m. each day, I think that's more about recovering from the whole process than the Ibrance. So far, so good.

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  • MichelleMME
    MichelleMME Member Posts: 7
    edited April 2017

    My MO informed me yesterday that due to the residual ILC in my skin that she'd give me a choice to either try the Xeloda or just take out my ovaries. She is not pushing one over the other since the Create-X study showed better results for triple neg and the study was primarily done on asian decent woman (I am white). So she is leaving the decision to me and need to let her know by end of this week. I too am curious to hear from those that are taking it for residual ER+/PR+, HER- and what SEs they may be experiencing. I am unsure what I want to do at this point.

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  • ABeautifulSunset
    ABeautifulSunset Member Posts: 990
    edited April 2017

    you should go onto the Xeloda thread in the Stage 4 forums and read a few pages. there are some fairly unpleasant side effects and it can't really be used long term for most people, maybe a few years before the SEs become intolerable. I've not been on it (yet) so you should read the thread for more info.

    :

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