No mutuations, will still develop ovarian cancer?

My understanding is that hormone positive breast cancers do not raise your risk of ovarian cancer. Those individuals who have certain gene mutations, like the BRCA and PALB2 and others, do have increased risk so they are usually recommended to have their ovaries removed.

HI stephilosopy:

That is good news.

I would add that the absence of a pathogenic mutation by current multigene panel testing does not exclude the possibility of any heritable component. One reason is that specific test panels do not include all genes (known or unknown) that may confer increased risk of breast or other cancers. Importantly, a very strong family history of certain cancers may be indicative of increased risk, despite negative panel test results.

Assume that one of the current multigene panel tests yields accurate negative results: "no mutation detected", plus no variants of unknown significance (also assume correct classification of such variants). "Detected" is a critical word, and what has been excluded is what has been specifically tested for. For example:

(a) Different multigene panels include different gene selections and different numbers of genes. Thus, in the typical case, not all known predisposition genes may have been tested.

For example, the current MyriadPro myRisk panel includes more than 25 genes:

https://new.myriadpro.com/products/myriad-myrisk/myrisk-gene-table/

Ambrygen's "BreastNext" panel currently includes 17 genes, but it includes MRE11A, NF1 and RAD50 which do not appear to be included in the above Myriad panel.

http://www.ambrygen.com/tests/breastnext

Many other panels are available. Genetic counselors choose test panels based on the results of the individual's genetic / familial risk assessment and other factors.

(b) We do not know all of the genes that when mutated may contribute to risk of breast cancer or other cancers, either alone or in combination. Obviously, such genes are not included in current panels.

(c) While specific gene rearrangements may have been tested, there may be other gene rearrangements in certain test genes that were not probed or detected.

(d) There is some (probably low) possibility of an undetected mutation located in areas of the genes that were not tested (e.g., certain non-coding control regions or certain intron sequences).

This is a rapidly evolving area and as more information becomes available, patients may seek further counseling to discuss possible additional testing in the future (if indicated). See for example:

Ruddy (2016): "Cancer Survivorship Care: An Opportunity to Revisit Cancer Genetics"

http://ascopubs.org/doi/full/10.1200/jco.2015.63.5375

(Free pdf available under "PDF" tab)

Be sure to obtain a complete copy of your test report and all associated documentation for your review and records. Please discuss the implications of your test results, including any caveats and limitations, in light of your personal medical and family history, with your genetic counselor.

BarredOwl