Endopredict test

Options
hawksfansarah
hawksfansarah Member Posts: 91
edited September 2016 in Stage IV/Metastatic Breast Cancer ONLY

Myriad Labs has the Endopredict test which uses immunotherapy to tell which chemo is right for you.

It sounds like an amazing advance, but it's only approved in Europe, not the USA.

I believe the test is currently seeking FDA approval in the US.

Any Europeans out there tried the test? How did it work for you?


· Share on FacebookShare on Twitter

Comments

  • Lisey
    Lisey Member Posts: 1,053
    edited September 2016

    Hawksfan,

    From my understanding the Endopredict is mainly like Oncotype (but apparently more refined). It doesn't tell you WHICH chemo will work, but whether or not one's risk is such that chemo is warranted.

    http://www.medscape.com/viewarticle/866023

    · Share on FacebookShare on Twitter
  • Vevs
    Vevs Member Posts: 91
    edited September 2016

    Hello there, I looked in to Endopredict but my Oncologist in The Christie's hospital in Manchester, UK, which is a centre of excellence for Cancer care, suggested I use an American company called Caris Lifesciences based in Phoenix, Arizona, for tumour testing. I have followed his advice. It was not free but my oncologist uses them for mets and more complex cancers. I hope this helps, the results have come back with many treatment options for my particular tumour which is very reassuring

    Elen

    · Share on FacebookShare on Twitter
  • Moderators
    Moderators Member Posts: 25,912
    edited September 2016

    Hi ladies! If you want, you can read more on EndoPredict Test in our main site. Hope this helps!

    The Mods

    · Share on FacebookShare on Twitter
  • Longtermsurvivor
    Longtermsurvivor Member Posts: 1,438
    edited September 2016

    Hope this is helpful, Stephanie

    Here are some options for having tumors profiled to determine their characteristics and possibly effective chemotherapy or other treatments:

    Genetic testing involves a blood test where you're looking to see if you have a gene that would predispose you to cancer. Molecular profiling or tumor profiling is where tissue from an existing tumor is taken and the genetic code of the tumor is sequenced.

    Rational Therapeutics – Dr. Nagourney

    https://www.rational-t.com

    Caris - Target Now

    http://www.carismolecularintelligence.com

    Guardant Health

    http://www.guardanthealth.com/guardant360/

    MD Anderson's Clearinghouse project

    http://moleculardiagnostics-cancer.com/uploads/files/1612/Funda_Meric-Bernstam.pdf

    See also:

    Foundation Medicine, a.k.a., Foundation One

    Clarient

    Precision Therapeutics

    Champions Oncology (in Baltimore, MD)

    ONCODNA

    · Share on FacebookShare on Twitter
  • hawksfansarah
    hawksfansarah Member Posts: 91
    edited September 2016

    This is so good to know, thank you!

    · Share on FacebookShare on Twitter
  • hawksfansarah
    hawksfansarah Member Posts: 91
    edited September 2016

    Ah, that clarifies things a lot. I had understood it the other way, that it could tell exactly which chemo would be best. Sigh double sigh. Science is too fast in some ways, too slow in others.

    · Share on FacebookShare on Twitter
  • Longtermsurvivor
    Longtermsurvivor Member Posts: 1,438
    edited September 2016

    Hi HawksFanSarah,

    We're writing about three types of testing - tumor profiling, OncotypeDX and genetic testing for inherited cancer syndromes like BRCA.

    The companies that profile tumors (listed in my post), should be able to direct you to which chemotherapies will and won't work for your particular tumor at this particular point in time in their development. Metastatic breast cancer is famous for changing mutations over time and even containing different types of cells in the same tumor.

    This cancer survival mechanism is part of what makes cancer so hard to get rid of completely - it just keeps changing. Think of antibiotic-resistant infections or pesticide-resistant mosquitos or herbicide-resistant crops. All beings want to live and they create cellular strategies to survive onslaughts of poisonous and lethal toxins. Cancer is made up of our good cells gone bad - it too wants to live and will change to survive.

    Our bodies want to live too, so it's important to support healing on all levels, not rely only on treatments to get rid of cancer.

    Rational Therapeutics website does a good job of describing the potential of tumor profiling.

    OncotypeDX wouldn't apply much in MBC, because it evaluates whether or not chemo is called for in those with earlier stage breast cancer - different test used for different reasons.

    And genetic testing blood tests are to determine the possibility of having a mutation that puts you at risk inherited risk of cancer. The most famous of these mutations of is BRCA that increases the risk of ovarian and breast cancer. Plus, it can help guide treatment options as there are a few BRCA mutation-specific drugs that aren't used outside those with the mutation. Angelina Jolie is the most famous, recent BRCA celebrity spokeswoman.

    Pretty much everyone with ovarian cancer is checked for BRCA mutations. Those with breast cancer, not so much unless they have a strong family history, were diagnosed at a young age and/or have bilateral breast cancer.

    Hope this helps to clarify things.

    Best, Stephanie

    · Share on FacebookShare on Twitter

Categories