Has anyone been on Olaparib?

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Sharon1960
Sharon1960 Member Posts: 3
edited June 2016 in Stage IV/Metastatic Breast Cancer ONLY

My oncologist mentioned the possibility of trying Olaparib, which I know is specifically for ovarian cancer, but has been tested on TN BRCA 1/2, Stage 4 breast cancer patients. I'm curious to find out if anyone has been on it and how it worked for them. Thanks!

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  • 3-16-2011
    3-16-2011 Member Posts: 559
    edited June 2016

    I have asked about parp inhibitors on this site in the past and got many responses. I am brca 2 and have seen optomistic research about the possibility of parp inhibitors working for brca 1&2 breast cancer patients. Good luck

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  • Pillow
    Pillow Member Posts: 11
    edited June 2016

    I've been on olaparib since 12/2014 as part of a phase 3 trial for brca+ patients. I had close to a complete response, but after a year, had a little progression in some mediastinum nodes. Radiated those nodes in 12/2015, and went back on the olaparib, with no or very little progression (last CT was a little ambiguous).

    Olaparib, a.k.a. Lynparza, has been approved by the FDA for stage 4 ovarian cancer (maybe just for brca+ patients???), and I expect will be approved for breast in the next couple of years.

    The pills, 2x/day, may cause a little fatigue, but otherwise, I've had no side effects.

    You can PM me for more info.

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  • cb123
    cb123 Member Posts: 320
    edited June 2016

    Pillow,

    Thank you so much for being part of the study. You're being very brave.

    I know that the Olaparib is a chemo drug taken orally, I'm wondering if you're using it with another traditionally administered (IV) chemo drug and if so what's your IV chemo cocktail?

    I'm so anti-chemo but it's impossible for me to be anti-Olaparib with my BRCA 1 mutation.

    cb

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