Anyone here w a blood clotting disorder on endocrine therapy?

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LoveMyFamily
LoveMyFamily Member Posts: 58
edited July 2016 in Hormonal Therapy - Before, During, and After

I was diagnosed w bc earlier this month. Have had the surgery and will have my initial consult with a med oncologist later today... my bc surgeon suggested that radiation / endocrine tx would likely follow surgery. Thing is, I have a serious blood clotting disorder and have been on warfarin for about 11 or 12 years and am considered a lifer when it comes to warfarin. I'm worried the endocrine tx will bring on clots ... anyone else in the same boat? My clotting disorder stems from inherited protein c defiency. If you have a blood clotting disorder (i.e., clot too easily), what did your medical oncologist advise about endocrine tx?

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  • MelissaDallas
    MelissaDallas Member Posts: 7,268
    edited June 2016

    I don't have a clotting disorder, but I did have a pulmonary embolism when I had ovarian cancer. The MO said no to tamoxifen and raloxifene because they are a clotting risk (small), but the aromatase inhibitors do not carry the clotting risk so it was suggested I take Aromasin. You must be menopausal or have your ovarian function suppressed to take the AIS though.

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  • Jojo0529
    Jojo0529 Member Posts: 193
    edited July 2016

    hello, I have factor v - only had tamoxifen for 2 months.. Then oopherectomy and Anastrazole ... The ai is a little tougher in my opinion .. But necessary

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  • chrissyb
    chrissyb Member Posts: 16,818
    edited July 2016

    I'm factor V as well and have been on Femara (an AI) for six years now with no problems at all. Good luck with your choice,

    Love n hugs. Chrissy

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  • cive
    cive Member Posts: 709
    edited July 2016

    On Warfarin for life because I have afib which increases my chance of a stroke. I take letrozole(Femara) with no problems.

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  • kira1234
    kira1234 Member Posts: 3,091
    edited July 2016

    I do know tamoxafin can cause thrombosis. Unusual but with your history something to consider.

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  • obsolete
    obsolete Member Posts: 466
    edited March 2017

    Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial

    Findings 1920 women were randomly assigned to receive anastrozole and 1944 to placebo. After a median follow-up of 5·0 years (IQR 3·0–7·1), 40 women in the anastrozole group (2%) and 85 in the placebo group (4%) had developed breast cancer (hazard ratio 0·47, 95% CI 0·32–0·68, p<0·0001). The predicted cumulative incidence of all breast cancers after 7 years was 5·6% in the placebo group and 2·8% in the anastrozole group. 18 deaths were reported in the anastrozole group and 17 in the placebo group, and no specific causes were more common in one group than the other (p=0·836).

    One quantitative interpretation is that there is merely a tiny 2-3% ABSOLUTE benefit in taking anastrozole as per above-named study. You need to discuss the risks with your physicians, as A.I.'s increase the risk of cardiac events. Ref. 2010 Breast Cancer Symposium, San Antonio: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC284405...

    Aromatase Inhibitors Increase Risk of Heart Problems

    http://www.breastcancer.org/research-news/20101210

    Compared with tamoxifen, use of an aromatase inhibitor was linked with a 26 percent increase in risk of heart disease. This is not a large increase in risk, but the researchers speculate that the risk may be greater for women who have other risk factors for heart disease.

    http://awomanshealth.com/news-from-the-33rd-annual...

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  • FLBuckeye93
    FLBuckeye93 Member Posts: 87
    edited July 2016

    I don't have a history of blood clots, but I'm factor V and prothrombin positive so no Tamoxifen. I'm on Arimidex and Zoladex for ovary suppression. Doctor also gave me meds to take for long haul flights, but I forget he name of it.

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  • LoveMyFamily
    LoveMyFamily Member Posts: 58
    edited July 2016

    thanks e1... I'll be on Femara when I start. Glad to read those of you w clotting issues are tolerating it well.

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