Scientists block breast cancer cells from hiding in bones

Options
Heidihill
Heidihill Member Posts: 5,476
edited June 2016 in Clinical Trials, Research News, Podcasts, and Study Results

http://www.eurekalert.org/pub_releases/2016-05/dum...


· Share on FacebookShare on Twitter

Comments

  • katcar0001
    katcar0001 Member Posts: 621
    edited May 2016

    Even though this is a study on mice, it is very interesting and shows promise to prevent bone metastases. I will be watching for more info on the human clinical studies of GMI-1271. I am hoping that Sipkin and her team follow up on further testing with plerixafor in humans, but it sounds like that is further in the future after more testing on mice. Thanks for sharing.

    · Share on FacebookShare on Twitter
  • JohnSmith
    JohnSmith Member Posts: 651
    edited May 2016

    Good post. This ties into "ER+ dormancy" and why early-stage HR+ disease can come back decades after initial diagnosis. With bone mets being common, this is a major problem that needs to be solved.

    TAGS added for future reference: E-selectin, Eselectin, GMI-1271, GMI1271 plerixafor

    · Share on FacebookShare on Twitter
  • Heidihill
    Heidihill Member Posts: 5,476
    edited May 2016

    katcar, plerixafor is already being used in humans to induce stem cell release to the bloodstream in bone marrow transplants.

    · Share on FacebookShare on Twitter
  • JohnSmith
    JohnSmith Member Posts: 651
    edited June 2016

    Hi katcar,
    I had not heard of GMI-1271, so did a quick google search.
    Ironically, results of a Phase I clinical trial of the E-selectin antagonist GMI-1271 (combined with chemo) for Acute Myeloid Leukemia (AML) were announced today, here and here.

    I'm not sure how helpful this news is, but figured it's worth adding it to this thread.

    · Share on FacebookShare on Twitter
  • cp418
    cp418 Member Posts: 7,079
    edited June 2016

    http://www.oncologynurseadvisor.com/breast-cancer/...

    New Therapy Blocks Breast Cancer Cells From Entering and Hiding in Bone Marrow to Form Latent Metastases

    · Share on FacebookShare on Twitter

Categories