High cholesterol? Statins? Uggg

Options

Hi everyone, I've been through BC twice and had chemo twice. At my latest physical with PCP my bloodwork showed high cholesterol. Total is 269, HDL 56 and LDL 191. My last chemo was the end of Aug 2015. I have always had slightly elevated levels but now they are quite high and my PCP wants to put me on statins. I've read so many different opinions on statins and the thought of taking any kind of RX bothers me. I've managed to loose 27 pounds since sept and make a point of walking 5 days a week, aiming for 150 minutes a week. I'm on a low carb diet and do try to watch what I eat. I know that the liver can take quite a hit with chemo and am wondering if others have had high cholesterol after tx. Any opinions on statins?

Thanks, Shari

Comments

  • vlnrph
    vlnrph Member Posts: 1,632
    edited March 2016

    Congrats on the 27 lb wt loss (and high HDL="good" cholesterol) plus being thru BC chemo twice!

    I assume you are reporting fasting lipid levels. Did the lab also calculate a ratio?

    With any family history of cardiac issues, statins might offer protection against heart attack, etc. Their anti-inflammatory action is a potential advantage. You could try a low dose taken at bed time for best results.

    A coenzyme Q supplement may be something else to consider especially if muscle achiness develops

  • muska
    muska Member Posts: 1,195
    edited March 2016

    Hi slv58, I had slightly elevated cholesterol levels soon after chemo and my PCP advised strenuous exercise for one hour 4 - 5 times a week. By that he means any type of aerobic exercise that gets your heart rate up like running, kickboxing, etc. I am nowhere near the target level but I try doing 'serious' exercise at least twice a week in addition to one or two more gym activities like yoga. Combined with diet, that lowered my cholesterol back to pre-treatment levels despite my taking an AI.


  • leggo
    leggo Member Posts: 3,293
    edited March 2016

    Hi ladies. Slv, yes I did get high cholesterol after chemo/hormonal treatment, but managed to get it down by cutting out ALL fat for several months. It never went back up, but I was also no longer on hormonals at that time. Could have been a coincidence. I actually use a statin, combined with metformin as an actual cancer treatment. Not a decision I expect everyone to be comfortable with, but I am curious about thoughts on the COq enzyme. Yes, statins deplete that, but I'm unsure that that's not the point when it comes to battling bc. I have read that supplementing the enzyme does more harm than good, but all of this is based on my family physicians opinion. A little Google research seems to confirm that but it's the internet :), so..... Anybody have any thoughts? Just spitballing while I do my own review of stuff I should/shouldn't be taking long term.

  • slv58
    slv58 Member Posts: 1,216
    edited March 2016

    Thank you for replies ladies. In Sept. I had bloodwork done that showed I was in diabetic range- this instigated me to start low carb diet and walking. I've been able to get it down to 'pre diabetes' range and have read that statins can cause blood sugar to rise. After my first time with chemo I was left with very sore joints. I'm being seen by a rheumatologist and he ran every test he could and diagnosed me with chemo related osteoarthritis. I'm nervous about statins causing this to intensify.

    I have read so many different opinions on statins and high cholesterol - I'm confused

  • SpecialK
    SpecialK Member Posts: 16,486
    edited March 2016

    slv - I had cholesterol that climbed from a normal-low reading for total number to above 200 after a total hyst/ooph at 45 - nine years prior to breast cancer diagnosis. I was put on a statin about half way through that time period - so I had been on it for several years prior to BC treatment. I did not have regular glucose readings during that time. My glucose readings were high throughout chemo, which also involved steroid use - which can raise blood sugar, and continued to be high afterward. I continued on the statin for a couple of years post-chemo, while also being on an AI. I did have muscle/joint pain (probably mostly due to the AI drugs), and my glucose remained in the pre-diabetic range. I asked my primary care if I could go off the statin and I started a step-down in dosage with the admonition that if the numbers went up I needed to stay on. I weaned off and the number remained stable enough that my PCP actually said that due to my ratio he was not sure I should have ever been put on a statin. I did not notice a measurable decline in muscle/joint pain, but I was glad to be taking one less med. I have remained stable on the cholesterol and ratio, but my glucose has remained relatively high. I did change my eating habits and actually dropped the total cholesterol number by 30 points, did decrease my joint pain because this eating change is anti-inflammatory, but my blood sugar remains higher than I would like. I attribute this to taking the statin, and am now going to pursue asking my MO about metformin. I had asked him previously and he said I should consult my PCP, they declined putting me on it because of the GI side effects and not enough data yet on benefits for breast cancer patients. I recently had the BCI test done to determine whether remaining on an AI past five years will provide benefit. Despite my recurrence risk coming back high on the test the drug benefit tested low, so I will be looking for answers regarding any ways I can mitigate future risk.

  • slv58
    slv58 Member Posts: 1,216
    edited March 2016

    Thank you for sharing SpecialK, I'm so tired of dealing with health issues. Shortly after my first chemo I had to beg my PCP to test my thyroid- I had several symptoms that warranted investigating but she really didn't think so. Turns out I was right and am on meds for that. I have read some information stating that metformin can reduce LDL levels. I did try - armed with lots of research, to get my PCP to put me on metformin after I finished tx the first time. She refused. I am thinking that I may ask her if I can try using metformin to lower LDL before statins. I really don't want to be on meds especially with the possible side effects that affect quality of life. Joint pain has been a very serious problem for me. On the other hand I just had an oophorectomy which may put me at higher cardiac risk.

  • SpecialK
    SpecialK Member Posts: 16,486
    edited March 2016

    slv - there is more discussion lately regarding cholesterol levels being less of a cardiac factor, and inflammation being more of one. That was yet another reason I decided to change what I eat, and I was quite surprised that both my glucose and A1C didn't fall lower - which may be more of an argument for me to try metformin. I did experience less joint pain though and did lose weight. Are you on any meds for the blood sugar issue? It seems like you would be a good candidate for trying metformin. I also have had some symptoms of thyroid symptoms, and test normally. At my last MO visit I had high blood calcium, he looked at my parathyroid - also normal test result.

  • slv58
    slv58 Member Posts: 1,216
    edited March 2016

    SpecialK, can I ask what you eat to reduce inflammation? At present I'm not taking anything for my blood sugar as I was told that the high level was probably due to steroids during chemo. It scared me and I did gain a lot of weight so I put myself on a low carb restricted diet and started walking. After 3 months I lost 20 pounds and lowered sugar quite a bit. Still trying to loose more to get into a healthy BMI. I've alwYs felt that inflammation was a cause of a lot of my problems. I'm not sure what my rheumatologist tested but said I didn't have markers for inflammation but I'm sure adopting an eating plan to reduce would only benefit.

    I have also read about a shift in thinking regarding cholesterol levels and cardiovascular health. I think the changing opinions is what makes it so hard to know what to do and I'm the type of person who likes to research options before deciding. I don't have the most faith in my PCP as she didn't even know what triple negative breast cancer was

  • SpecialK
    SpecialK Member Posts: 16,486
    edited March 2016

    slv - lol! It is more what I don't eat I follow the Virgin Diet (written by J.J. Virgin, definitely doesn't turn one back into a virgin, ha!) and you eliminate, and I mean completely, dairy, sugar, eggs, soy, corn, peanuts, and gluten - according to this diet for 30 days. Then you can add things back in one week at a time to see what things you react to. The only thing I added back was eggs, and I only eat them sparingly. I originally tried this because I had been unable to lose weight with old-school calorie counting and sensible eating combined with exercise, 5-6 miles daily and some gym work. I lost absolutely nothing and I was very frustrated as brisk walking daily with the South Beach diet had always worked for me in the past. My former boss tried the Virgin Diet to try to help arthritis in her hands - she is a blood banking medical technologist and her license requires her to be manually dexterous and she was really struggling with synovial cysts and pain. So, she tried this and could make a fist in less than a week! She was probably a size 8-10 prior to the diet and was not to lose weight, but she started losing, and she kept going until she was a size 4-6! She did not exercise at all. I started the diet in Jan 2014 and had three back to back surgeries in Mar/Apr/May so was not exercising and I still lost 22 lbs by the end of May. My LE was better, my joint pain was better and I just felt less bloated and slow, and dropped the cholesterol points - but not my blood sugar. This is a HARD diet, I will not lie. You have to be committed and really be a detective about labels and eat very little processed food. I found the best way to follow it is to eat whole food in its most natural form, and have go to condiments that you have researched and know are suitable. If you are interested I can certainly provide those. Here is a link to a blog that gives a good summary. I did buy the books, but if I had it to do over I would skip her first book and go straight to the cookbook because it explains enough about the premise of the diet.

    http://www.chewfo.com/diets/the-virgin-diet-by-jj-virgin-2012-what-to-eat-and-foods-to-avoid-food-list/

    Eeesh on the primary care not knowing what TN BC is - that makes it hard to be confident. I have a revolving door of primary care as I am seen at a military base - sometimes I get a new one and I haven't even met the outgoing one yet, lol! The saving grace is a women's health nurse practitioner that has been through BMX and recon, and the person who handles my referrals - who is also a nurse - who is the bomb, love her to pieces. I even took her flowers, she has been a great help.

Categories