TNBC and fat

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Interesting press release not ready for clinical trials, but maybe worth trying as it might help and probably won't hurt unless you're dealing with cachexia, then you've got another problem to solve.

Triple-Negative Breast Cancers Depend on Fat as Fuel, Research Shows

UCSF Scientists Halt Growth of Challenging Tumors With Drug That Blocks Fatty Acid Metabolism

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  • JohnSmith
    JohnSmith Member Posts: 651
    edited March 2016

    This deals with cancer "metabolomics". There's a growing research community that believes cancer is partially a metabolic disease. Metabolomics exploits the Warburg effect, and the notion that all cancers have altered energy production.

    The general consensus is that many factors are necessary to induce cancer, including metabolic, genetic, and cell signaling issues. They are all interrelated.

    There's hundreds of labs already working on metabolomics. There are a half dozen chemo drugs that attack the cell division machinery, but also target metabolism. There's also many more drugs that are not developed for cancer, but may exploit cancer metabolism, such as the drug, Etomoxir, which is highlighted in this UCSF study for TNBC. The trouble is that Etomoxir has been shown in clinical trials to be highly toxic. Another drug which is theorized to affect with cancer metabolimcs is the diabetes drug, Metformin, which is in over 150+ diferent cancer clinical trials. Another one that comes to mind is the old malaria drug, Chloroquine (CQ) and Hydroxychloroquine (HCQ). There's so many more. Most of these fall under "drug-repurposing", the small but growing effort to take old drugs and turn them into cancer drugs.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited March 2016

    Longtermsurvivor, Thank you for posting this info.

    JohnSmith, I take the drug Hydroxychloroquine (Plaquenil) for my RA. In July I had a CT scan which showed a 6mm long nodule. I ran out of my Plaquenil several months ago and didn't get to the pharmacy to refill my prescription. My last CT showed that the 6mm nodule had grown to 1.5cm. This makes me wonder if the growth was due to me stopping the Plaquenil. I've since restarted Plaquenil and will be having a PET scan on March 18th. I'm very curious to know if restarting the Plaquenil will have an effect on the size of the nodule. Very interesting info you posted. Thank you.

  • Fallleaves
    Fallleaves Member Posts: 806
    edited March 2016

    I hope your next PET scan shows slowing or regression, Slowdeepbreaths. Please let us know what your scan shows. It would be nice if some of the old (and cheap) drugs turn out to be effective cancer treatments, as JohnSmith mentioned.

    I seem to recall reading that a low-fat diet is particularly beneficial to TN patients. This research would explain why. (I'd guess that a ketogenic diet should be avoided by this group!) Of course, it's hard to starve cancer, because it can be fueled by glucose, glutamine or alpha-ketoglutarate. But perhaps as the above research indicates, different types of cancer cells have different fuel preferences that can be exploited.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited March 2016

    Thanks Fallleaves!!

    I'm still waiting to hear. I'm anxious to know if it made a difference. Hopefully I will hear something tomorrow.

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