Old red dye shows promise as new cancer foe
http://newsdaily.com/2016/02/old-red-dye-shows-promise-as-new-cancer-foe/
Repurposing non-drugs, hmmmm....then charging more.
Comments
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Interesting. The sulfa drugs were developed from textile dyes.
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http://www.foodsafetynews.com/2010/07/popular-food...
Granted this is an older article but I still would have reservations about dyes....
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Interesting article Cp. I always knew that red and yellow dye were horrible. I read somewhere also that any processed "orange" food gets its color from fire retardant. That's scary. I wonder too about tattoo ink. My favorite artist refuses to use red, orange, yellow, pink and some shades of purple. I wonder if he knows something I don't when it comes to those ink colors. Hmmmm.
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leggo, that is very interesting about the tattoo ink colors. Have you ever asked your artist why?
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I had read somewhere, and can't find it again, that there is a connection with Adriamycin and the colorant used on our car's rear red light covers. That there is a chemical used in both of them that gives it the lovely red color. Any body else hear that?
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In the 1950s, an Italian research company, Farmitalia Research Laboratories, began an organized effort to find anticancer compounds from soil-based microbes. A soil sample was isolated from the area surrounding the Castel del Monte, a 13th-century castle. A new strain of Streptomyces peucetius, which produced a red pigment, was isolated, and an antibiotic from this bacterium was effective against tumors in mice. Since a group of French researchers discovered the same compound at about the same time, the two teams named the compound daunorubicin, combining the name Dauni, a pre-Roman tribe that occupied the area of Italy where the compound was isolated, with the French word for ruby, rubis, describing the color.[31] Clinical trials began in the 1960s, and the drug was successful in treating acute leukemia and lymphoma. However, by 1967, it was recognized that daunorubicin could produce fatal cardiac toxicity.[32]
Researchers at Farmitalia soon discovered that changes in biological activity could be made by minor changes in the structure of the compound. A strain of Streptomyces was mutated using N-nitroso-N-methyl urethane, and this new strain produced a different, red-colored antibiotic. They named this new compound Adriamycin, after the Adriatic Sea, and the name was later changed to doxorubicin to conform to the established naming convention.[18] Doxorubicin showed better activity than daunorubicin against mouse tumors, and especially solid tumors. It also showed a higher therapeutic index, yet the cardiotoxicity remained.[33]
here is the history of Adriamycin. No idea about the color and tail lights though. -
This is a very interesting thread. So is this why Macrobid turns some people's urine red?
To answer your question glennie, no he never said why. I didn't get a tattoo until after I was diagnosed with metastatic bc (bucket list and I didn't want to be one of those saggy tattoo seniors). When I filled out the consent form with all my medical history, the girl at the desk just recommended this guy, who subsequently said those colors are known to cause weird reactions in healthy people so I just took his advice when he said " why borrow trouble" and let him decide the colors. Got good vibes....cared about my health, knew his stuff.
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If a simple red dye could cure or prevent cancer, it would be all over the news and there would be a lot of people doing the dance with you.
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Yes, I read the article. Then I read that PFIZER holds the co-patent on PV-10, which will have to be used in combination ('cos they say so) and then I no longer had faith in it. Heaven forbid they inject us with some dye and we're all cancer free. You don't really think that's going to happen do you? Used alone maybe, anything's possible, with Pfizer's mitts on it....never.
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Sulfa was a "simple red dye." It's saved a huge number of lives.
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glennie19 your history of adriamycin is fascinating! Thanks for posting
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I've been searching for cancer cures for 8 years and, yes, this sounded promising (that's mainly why I posted it), but reading the part about Pfizer and combining PV-10 with Keytruda made me roll my eyes. A larger study could very well prove the drug or combination effective but if Pfizer/Merck/Provectus decided for their own profit-seeking reasons not to market the drug or the combination, they don't have to tell anyone the results of the study.
I wish we could do some crowdfunding, buy out Pfizer, and get the ball rolling on this ourselves!
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I clicked on one link and thought it was interesting how they differentiate rose bengal ablation from cryoablation or hyperthermal ablation, which was the question forming in my mind. It's the antigens!
Will read more later...thanks for the link.
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I find it interesting that the stock (an OTC) is only worth 45 cents a share. If you want to look it up, its called PVCT.
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Oh, and the co founder of the company just resigned! And also, the stock was selling for almost 3000 dollars a share in 2002. Oh, sorry, I saw where you just said that.
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I saw you there too! I hope your shares go back up!
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I found THIS very interesting:
Board Stats: 79 members / 555 guests Provectus Biopharmaceuticals, Inc.
PVCT / Message Board / Read Message
BOARD GROUPS return to message board, top of board Msg 27232 of 27259 at 3/3/2016 1:19:12 PM by NickSanta They're coming around!
The other day I posted about a breast cancer discussion forum where a member posted the Reuters article. I included their comments to show how blind they were to the potential of PV-10.
I decided to join and reply to them. I even provided a link to Dom's blog. Here's what they are saying now...
"I clicked on one link and thought it was interesting how they differentiate rose bengal ablation from cryoablation or hyperthermal ablation, which was the question forming in my mind. It's the antigens! Will read more later...thanks for the link."
"NickSanta - that does paint a better picture of the response rate. I truly do hope it pans out in the long run. I lost a friend to melanoma 3 years ago."
"I'm afraid I'm now preconditioned to be a bit skeptical of Phase 1 and 2 results because I participated in a neoadjuvant trial (Phase 3) that illustrated the difficult path to successful new treatments. In that study, Phase 1 and 2 returned pCR rates in the study arm that were 40 points higher than in the control group. It was phenomenal. But, once the protocol was tested in a large number of patients during Phase 3, the advantage completely disappeared. The final results were virtually identical in both arms of the study so statistically insignificant.
"I sometimes think of the years of work and vast sums of money that went into the study I was in and the researchers' surprise at the final outcome. Research like this is so unpredictable!"
"I hope this dye has continued success!"
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I found THIS very interesting:
Board Stats: 79 members / 555 guests Provectus Biopharmaceuticals, Inc.
PVCT / Message Board / Read Message
BOARD GROUPS return to message board, top of board Msg 27232 of 27259 at 3/3/2016 1:19:12 PM by NickSanta They're coming around!
The other day I posted about a breast cancer discussion forum where a member posted the Reuters article. I included their comments to show how blind they were to the potential of PV-10.
I decided to join and reply to them. I even provided a link to Dom's blog. Here's what they are saying now...
"I clicked on one link and thought it was interesting how they differentiate rose bengal ablation from cryoablation or hyperthermal ablation, which was the question forming in my mind. It's the antigens! Will read more later...thanks for the link."
"NickSanta - that does paint a better picture of the response rate. I truly do hope it pans out in the long run. I lost a friend to melanoma 3 years ago."
"I'm afraid I'm now preconditioned to be a bit skeptical of Phase 1 and 2 results because I participated in a neoadjuvant trial (Phase 3) that illustrated the difficult path to successful new treatments. In that study, Phase 1 and 2 returned pCR rates in the study arm that were 40 points higher than in the control group. It was phenomenal. But, once the protocol was tested in a large number of patients during Phase 3, the advantage completely disappeared. The final results were virtually identical in both arms of the study so statistically insignificant.
"I sometimes think of the years of work and vast sums of money that went into the study I was in and the researchers' surprise at the final outcome. Research like this is so unpredictable!"
"I hope this dye has continued success!"
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The enthusiasm "NickSanta" displayed for this PV-10 cancer drug is dubious.
A simple google boolean search confirmed my suspicions.
He's an investor in Provectus Biopharmaceuticals, the company running the PV-10 clinical trials.
He's been a regular on the investorvillage.com investment forum for the last couple months posting about the stock, PVCT.
Based on the posts, he scours the internet looking for any news related to the stock. It's no coincidence that he registered for this forum after Heidihill posted this news. His comment above "This is the first I'm hearing of it" is an obvious lie.
I also found his investorvillage.com post, here, condescending towards the ladies (see image below since link may not work)Is he a "caregiver"? Perhaps, but I seriously doubt it.
I find it a bit sad that he joined a cancer support forum to "talk up" an approach that doesn't have any relevance for this community.
While it's true that Provectus sponsored a PV-10 Phase 1 breast cancer trial, here, that ended in 2008 (15 patients), there appears to be no Phase II breast cancer trial on the horizon. We all know how the FDA drug approval process works, so EVEN if this was proven to work, it would be at least 5-10 years from the clinic.
Good luck with your penny stock Nick. -
I don't know how you did it, John Smith, thanks, I couldn't get the yellow part over here. I think he owns a LOT of stock in PVCT. And so he is probably hoping the stock goes up from its profoundly amazing price drop, from around $3000 a share in 2002, to its price of less than fifty cents today. A good price to buy, but not to sell. And it doesn't look like any "big pharma' is interested in buying out the drug or the company, that I know about.
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Sheesh...What else can I say? I hope the Mods do something about this.
Thanks, Tomboy and JohnSmith.
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I actually hope the Mods leave it up, as I did contact my local news.
m
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nicksanta- you are an ass. How dare you come on here and mislead people. Are you kidding me? We are bunch of women (and men) with breast cancer. You have the gall to join our forum and condemn a valid discussion, belittling us? I don't care how big or small your investment is, you are scum
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And after you have been outed, you are still trying to talk this trial up. You can guarantee that we are all completely dubious of any potential for this drug, and you have yourself to thank for that
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you are not even supposed to be on this site. It's a safe place for us and you violated that. It is not a place to advertise or tout drugs with which you are affiliated.
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Dear Members,
NickSanta reported himself to the Moderators with an apology and we subsequently banned him from further activity on the boards. Feel free to alert us via PM when you suspect that someone may be in violation of the community rules.
The Mods
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He reminds me of Martin Shkreli a little. Or maybe quite a bit.
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Well, we do know that said MS does have some time on his hands these days...
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OKaaaay, you two! Who is Martin Shkreli??!!?!
Mods, I was more concerned because what he did was a very feeble attempt at stock manipulation. It really wasn't about him being here, at all, at least for me. Stock manipulation is a very serious crime. I did take note of his not so nice remarks. That's okay, though: I did get screen shots of all of his posts before his existence was erased from here.
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Tomboy, google MS. He's a walking, talking, smirking example of karma catching up with a horrible human being.
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