Tamoxifen or Aromatase Inhibitors for PREmenopausal patients?

Stranger_TK · October 2015

Hello there!
Please share your experience or help me with advise!
Which is better, more effective for PREmenopausal women:

1) only Tamoxifen,
2) Goserelin + Tamoxifen or
3) Goserelin + Aromatase inhibitors?

What do your doctors say? What do you think?

I am 36 years old, Breast cancer 2a stage (T1N1M0), hormone-positive Luminal B type.
IHC Er+ (90%), Pr+ (90%), Her2 +1, ki-67 43%.
I had radical mastectomy and chemotherapy 4AC+4T (with Goserelin injections during chemo) this year. Just finished.

Now I have to start hormonal therapy. Different doctors prescribe me different types of hormonal therapy, so I don't know which to chose!

inks · October 2015

You can google SOFT and TEXT trial results or search those terms on these boards and you will see that ovarian suppression with aromatase inhibitors is slightly more effective in younger women than the other regimens. Good luck!

Moderators · October 2015

Welcome Stranger,

As Inks mentioned, there are some really interesting study results about this. For more info, read the main Breastcancer.org site's research news articles about:

June 2014: Aromasin Plus Ovarian Suppression Reduces Recurrence Risk Better Than Tamoxifen Plus Ovarian Suppression in Premenopausal Women Who’ve Received Chemotherapy (with video)
December 2014: Aromasin Plus Ovarian Suppression Reduces Recurrence Risk Better Than Tamoxifen Plus Ovarian Suppression in Premenopausal Women

We hope this helps!

--The Mods

Stranger_TK · October 2015

Thank you so much! These links are very helpful!

Stranger_TK · October 2015

Thanks a lot! That's was what I needed!

peggy_j · October 2015

I was 46 and pre-meno when I started tamox. After two years, I lost bone density. Now that I am post-meno, I've gained back some of that loss. My MO says the bone loss does not happen to all patients. (I was already at high risk for osteoporosis). If you're concerned you can do a baseline DEXA scan now and then again in two years.