TORADOL (ketorolac) linked to Recurrence Prevention

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  • Stephmoen
    Stephmoen Member Posts: 563
    edited September 2015

    well I have a hematoma on my right side non cancer side may need to go back into surgery :( my hemoglobin is also low at 8 May need a transfusion

  • Stephmoen
    Stephmoen Member Posts: 563
    edited September 2015

    no more toradol for me I'm cut off due to the bleeding :(

  • geewhiz
    geewhiz Member Posts: 1,439
    edited September 2015

    Oh gosh Stephmoen - I'm praying for you to feel better quickly!


  • Loveroflife
    Loveroflife Member Posts: 5,563
    edited September 2015

    So sorry Steph for the complication.I would think the risk of bleeding with Toradol is higher in those with tissue expander(s) placement ( secondary toforeign objects in the cavity) vs. those without. Any comments on this Dr. Retsky ? Hope you are still with us.

  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited September 2015

    Stephy, just woke up. Hematoma.Chit. Sorry Steph. Well that deep-sixed.the day. Why can Forget have > 1000 and no bleeding and this doc has one with a hematoma.

    What dose did she use preincision? What dose did she give you post op and how long after the first dose? What was the interval between doses? Are you taking your pain med--Norco . Were you wrapped? Did you lift anything? The baby? How long after last dose did you think you had a hematoma? Is the incision together? Did you use that arm to get out of bed? Did you log roll or push off with arm that has hematomaDid you use that arm for toileting? What color is your skin--pale white? What color is your hair?


    Your HGB is 8, what was it preop, What is your hematocrit preop. What were your platelets preop, What was your estimated blood loss in surgery? Relevant questions, but obscure too you now.

    Are they going to do a repeat Hemaglobin/hematocrit before deciding to do a transfusion? Ask that a platelets be run too.

    Is your pain under control?

  • HomeMom
    HomeMom Member Posts: 1,198
    edited September 2015

    I am past all of my surgery except the nipple recon, so I'm not sure this is something I could or should look at. Was this mainly for the cancer surgeries and not recon?

  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited September 2015

    Homemom, Lost my post. Stick around . That's an answer that is unknown. Theoretically, toradol could prevent existing dormant cells from awakening. When's your surgery.

  • HomeMom
    HomeMom Member Posts: 1,198
    edited September 2015

    I am going to schedule it for next month - third or fourth week

  • Fallleaves
    Fallleaves Member Posts: 806
    edited September 2015

    Stephmoen, I'm so sorry you had such a rough night with pain, and that you are dealing with a hematoma and low hemoglobin. Wish I could help you out in some way, and I really hope I didn't HURT you by jumping on the anti-opiate bandwagon. Hope things start going better for you VERY soon.

    For anyone worried about opioids, Sassy is absolutely right, pain management is the number one priority. Opioids are a mixed bag, and there seems to be a movement to minimize them. But in providing pain relief they provide a large benefit. If using them is all that work, your body is still coming out ahead by avoiding the effects of pain. As Sassy mentioned, it's dose dependent, as well. So, low doses of opioids, switched up with other pain relievers aren't going to be harmful.

  • solfeo
    solfeo Member Posts: 838
    edited June 2018

    Oh Steph, so sorry to hear it! As I said yesterday I so hope that doesn't happen to me because it will put my surgeon off of using the Toradol for anyone else in the future. I need to have a talk with her about that and tell her I'm willing to take the risk and ask her not to give up on the idea completely if I do have complications

  • Stephmoen
    Stephmoen Member Posts: 563
    edited September 2015

    yes I'm doing ok now on norco hading pain my drs do say toradolay have played a role but not to dwell on it I will be honest getting through this without opiods is very difficult I am avoiding morphine because that's what must studies are based on but I do need pain meds hemoglobin is at 7.7 hoping it goes up now bleeding stopped and won't need transfusion

  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited September 2015

    Steph, did you get any other number? Unusual bleeding to be caused this long. Platelets/hematocrit. Your nurse will give you your preop and post op numbers all you have to do is ask. Docs can say it played a roll, but unless a full chart review is done that is laying blame on a drug is an excuse not an answer. Sorry, you are going through this sweetie sassy

  • solfeo
    solfeo Member Posts: 838
    edited June 2018

    Probably not something anyone here has thought of with regard to Toradol, but since it came up for me there is bound to be someone to come along later with the same experience. My EKG was abnormal in my pre-op physical last week. It showed a condition called Long QT, which is a heart rhythm disorder. Sometimes it is genetic, but it can also be caused by certain medications or nutritional deficiencies. This was the first time for mine so there was probably a temporary cause for it, although I think the genetic variety can spring up out of nowhere later in life as well.

    When I was looking up a list of drugs to be avoided, I found a study with ketorolac on a list of meds that can cause Long QT when used after surgery. There are others and it's not that unusual after surgery, but it's temporary. Not something you want to make worse in someone who already has it though.

    That was the morning after I spent all night in the ER with my husband who had a MRSA infection. I was very dehydrated, hadn't eaten and had been running myself ragged dealing with his problem while trying to get everything done I needed to do for the cancer. I had a feeling that was what was causing the problem, and that there was nothing really wrong with my heart. I was concerned about the Toradol under the circumstances so asked my doctor to repeat the test in a week to give me a chance to take better care of myself.

    I worked on my nutrition, getting plenty of fluids, and getting my electrolytes back in balance - all stuff we should all be doing all the time, but it is hard sometimes when we have so much going on at this very stressful time in our lives. Went back for the follow-up test this morning and all was normal. Now I go into the surgery with at least one concern about the Toradol handled. Removing any drugs or supplements that might be causing it is another way, but that didn't happen to apply to me.

    So if this ever happens to anyone else, there are probably ways you can reverse the Long QT by taking care of yourself, or removing any offending substances. Unless your problem is genetic and permanent. In either case you would want to have a conversation with your surgeon about the Toradol. It wouldn't necessarily mean you can't use it, but they should be aware that the Toradol can make things worse so they are watching for problems. I had spoken to my surgeon about the Long QT before I asked for the Toradol, but she didn't mention any possibility of aggravating the condition. I think this is one more thing that not all doctors are going to know about.

    JMO as always, but I don't think it is anything anyone should worry about unless they actually have Long QT, but wanted to put the information out there for those who do. Hope it helps someone.

  • Stephmoen
    Stephmoen Member Posts: 563
    edited September 2015

    my preop hemoglobin was 12.6 now it's 7.7 they stopped the bleeding so we will see if numbers go up I did not ask about platelets but I will

  • Stephmoen
    Stephmoen Member Posts: 563
    edited September 2015

    they say this is an issue that can occur and not necessarily from the toradol but obviously they do t want to give me something that can cause the bleeding issues to become worse I still am happy I did it pre op like I said this could be an issue for anyone not just from the toradol

  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited September 2015

    Stephy where exactly is the bleeding? Armpit, breast? Sorry, I know you aren't up to questions, but it's my thing. Detective work. Hoping for a smooth recovery.

  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited September 2015

    Solfeo, Talk with a Cardiologist. I wouldn't take Toradol. I'm and old Cardiac nurse too. But not well versed in long Q_T syndrome. Can be real trouble. Please, see what a Cardiologist says. Your surgeons a cutter. She has minimal to no knowledge about EKG's. She should have said so. Each doc has a skill. Once they are done with residency, the things they learned about the other specialties during residency rotations fades away.

  • Stephmoen
    Stephmoen Member Posts: 563
    edited September 2015

    around my draining tube I guess the tube was also blocked this is very typical for me to go 2 steps forward and 1 step back had my share of issues neutropenia in hospital after first chemo for a week after 5th infusion my port was infected and I went septic in hospital for a week with that and on antibitics iv for a month now this only good thing my pet scans and ultrasound showed cancer was gone! Can't wait for pathology reports come back

  • solfeo
    solfeo Member Posts: 838
    edited June 2018

    My PCP did speak to a cardiologist (and ran some extra bloodwork at his request - they cleared me), but regardless I don't really have it so it's not an ongoing concern for me. It was caused by the dehydration and not eating much for a few days straight. Good suggestion to speak to a cardiologist about Toradol and possible safety issues in patients with Long QT, in addition to making your surgeon aware.

  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited September 2015

    Stephy, Here I go said I wouldn't question Dying to know preop and post op Platelet counts. Ask her too if they did chemistries? Ask her to just make a list of all abnormalities on CBC and Chemistries.

  • Stephmoen
    Stephmoen Member Posts: 563
    edited September 2015

    norco is starting to upset my tummy and I'm worried about liver I had iv tylenol do you guys think small amount of morphine is ok my only ither option

  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited September 2015

    Solfeo, Oh my, my nose is bumping things.

    https://cardiology.ucsf.edu/care/clinical/inhere/arrhythmia/qt.html

    (this is just portions of info taken from this web page)

    Diagnosing LQTS can be difficult because individuals with the condition do not always have abnormal EKGs and QT prolongation can be intermittent. In fact, about a quarter of people with LQTS have normal EKGs and those with a long QT interval on one EKG may have normal EKGs at other times.


    Since LQTS syndrome is a genetic condition, the family members of someone who has the condition may be at risk of developing the abnormal heart rhythms. Close relatives (parents, siblings, and children) of someone with LQTS should be evaluated for the condition by consulting a cardiologist familiar with LQTS or through genetic testing if the gene mutation associated with the condition in the family has been found.

    Electrophysiologists are cardiologists who are experts in abnormal heart rhythms. Appointments can be made with the electrophysiologists at UCSF by calling (415) 353-2554. Electrophysiologists at other hospitals can be located by searching on this website.

    Precautions

    Individual recommendations should be made with the help of a cardiologist. Individuals with LQTS are often advised to avoid medications that prolong the QT interval. Such medications can bring out arrhythmias and can even cause cardiac arrest. A list of medications to avoid is maintained at www.qtdrugs.org. Additionally, people with LQTS should stay hydrated since dehydration can also provoke abnormal heart rhythms. It is a good idea for people with LQTS to wear a medical alert necklace or bracelet.

    Dangerous heart rhythms are sometimes associated with specific triggers in LQTS. There are different types of LQTS and certain event triggers have been associated with the different types. Sometimes individuals with LQTS are advised to avoid certain triggers such as exercise, particularly swimming, sudden loud noise, and extreme emotion depending upon their past symptoms and the type of LQTS they have.

    For more information on long QT syndrome:


  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited September 2015

    Stephy yes re' Morphine. Ask nurse to total amount of milligrams you've had of Tylenol since first does. Remember Norco has Tylenol in it

  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited September 2015

    Stephy you could ask for dilaudid. Great pain control

  • Fallleaves
    Fallleaves Member Posts: 806
    edited September 2015

    Wow, Steph, sounds like you've been through the wringer a few times already! Glad to hear your bleeding has stopped, and I hope your blood numbers come back quickly. That's pretty spectacular that your scans showed the cancer is gone! Hope your path results are great, too. I'm wishing you much smoother sailing from here on out!

  • Fallleaves
    Fallleaves Member Posts: 806
    edited September 2015

    Sassy and Steph, this paper, "Morphine Use in Cancer Surgery" ( http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151591/ ) offers some alternatives to morphine: tramadol, buprenorphine, and gabapentin among others. Don't know if any of those is appropriate for you Steph, but just wanted to pass along the info.

  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited September 2015

    Okay Steph there you have some alternatives. Just b/c Morphine on your list , doesn't mean nurse can't call for an alternative. It's done all the time. Tramadol is best choice

  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited September 2015

    Stephy, please, ask them as a nursing measure since you are acutely anemic, to either put you on or getan order for 2 liters of oxygen

  • solfeo
    solfeo Member Posts: 838
    edited June 2018

    I appreciate the concern, but I don't want to turn this into a discussion about me. I've never had an abnormal EKG before, no one in my very large family has it, and there was an obvious to everyone immediate cause for it (Occam's Razor - "The simplest explanation is usually the correct one"). There is really no cause for concern, I just wanted to help inform others since I hadn't seen the issue mentioned.

    I'm more concerned about Steph's bleeding, and my own risks since our procedures are similar. What Loveroflife said made sense to me that the risk of bleeding could be higher in one procedure vs. another. We don't really know do we? I wonder if anyone does?

    Steph, I have also had some visits from Murphy's Law along this journey (just not as far along as you), so I kind of know how you feel about nothing seeming to work out right. Congrats on the clean scans - that's big so enjoy the good news.

    I have had way too much waiting time to go back and forth about my surgery, but now I'm wondering if delayed reconstruction might be a better idea for me since I really want the Toradol. Opinions? Does anyone think having the BMX and reconstruction separately would lower my risk? Or if I'm gonna bleed I'm gonna bleed? I know some people are just more prone to it.

  • sas-schatzi
    sas-schatzi Member Posts: 19,603
    edited September 2015

    Solfeo, today i'm reaching brain dead. But perhaps I can call Forget. Called Retsky, why not?

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