Oncotype Gurus- asking for your assistance.

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PatRN10
PatRN10 Member Posts: 332
edited June 2015 in Stage I Breast Cancer

Oncotype Dx was not in last week when saw MO and she went on vacation. Since we discussed several scenarios she was OK with nurse e-mailing me the test.  just want to be sure I am interpreting the graph on page 2  right. My RS is a 23 or 15% on page 1. On the next page 2 , is  the solid bold line my expected benefit of Tam alone with the lighter lines the confidence interval above and below?   Just trying to wrap my head around this before next appt. These mid range scores are a bear.

Thanks


 

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  • MsPharoah
    MsPharoah Member Posts: 1,034
    edited June 2015

    Hi Pat.....so glad that you received your oncotype score. The graph attempts to show you the chemo benefit in terms of risk reduction for distant recurrence. It is the delta between the solid and dotted line. The mid range scores are so difficult...I know because my score is 24 (16% risk of distant recurrence with Tam). My report showed that I could possibly reduce the risk of distant recurrence from 16% to 12%. For me that was a lot. I took three other factors into consideration......first, the recommendation of my oncologist, second my overall health (would chemo be too difficult?), third...the opinions of my husband and two grown children. We were all agreed that chemo was a "go". I had 6 cycles of TC and did pretty good. I was fortunate in that I could work from home on those days when I felt lousy. Working was good for me...made me feel normal and removed the financial burden of being ill or in treatment. I hope that you find the peace that comes with a treatment decision. Whatever you decide...don't look back!
    Love, MsP
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  • PatRN10
    PatRN10 Member Posts: 332
    edited June 2015

    Thanks Ms P. ! Ok looks like I am on the right track. Ugh this is so hard! I am considering the following.

    1. ER is just 25%. Do I want to put all my eggs in that basket.

    but 2. Tumor is grade 1. will chemo be that  effective.?? 

    According to my report RS is 15% and chemo could get down to 11% .

    Thanks again!!!!

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  • MsPharoah
    MsPharoah Member Posts: 1,034
    edited June 2015

    Pat.....Ugh is right!!!! Do you have time to have the Mammaprint test done? That test does not have an intermediate result....either high or low. I didn't have time to have this test because my Oncotype test had to be redone with a new sample....the pathologist didn't send enough tumor!!!!! I just didn't want any more treatment delays.

    You make good points for consideration. My ER was 85% and PR was so low, considered negative, so the anti-hormonal was considered to be a "win" for me. My grade was a 1 too, with mitotic score a 1...but my K167 was 17% which is considered high proliferation. Do you know your mitotic and K167 scores?

    MsP

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  • voraciousreader
    voraciousreader Member Posts: 7,496
    edited June 2015

    Not sure of your age...however, if you are premenopausal and younger than 40....you might ask about the results of the SOFT/TEXT trials with respect to ovarian suppression for ER + HER2 NEGATIVE tumors.

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  • PatRN10
    PatRN10 Member Posts: 332
    edited June 2015


    Hi,  no I didn't get as mitotic score. No time for Mammoprint. My RO is chomping at the bit (surgery was 5/15) as Rads set up is 7/7. I also had to wait almost a month for this test for the same reason as yours!!! I would love to discuss with MO but she is on vacation. She indicated that unless score was really high to go forward with rads and can do chemo after if needed.

    The thing that makes this graph so confusing is that my RS of 23 is 15 % (CI of 18-12%) on page 1. Shouldn't that be where my bold solid line intersects at 23? Instead the light solid line is at 15 and bold solid line is at 11. and another light solid line at about 6. I thought this was representing the CI points spread for the RS but on page 1 that CI is between 18% and 12%. Shouldn't that tamoxifen only range be the same on both pages?

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  • PatRN10
    PatRN10 Member Posts: 332
    edited June 2015

    Hi VR. I am 52. So too old .

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  • MsPharoah
    MsPharoah Member Posts: 1,034
    edited June 2015

    The CI is expressed on page 1 that describes your recurrence score and % risk juncture. On page two there are two graphs with a line for Tam and a line for Tam +CMF (tam and chemo). And for each of these, there is a CI. You can call Genomics to get help reading your report. 8666626897.

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  • PatRN10
    PatRN10 Member Posts: 332
    edited June 2015


    I think I will. It seems to me the CI for tam alone should be the same on both graphs on page 1 and 2.

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