rads percentages

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Sites like adjuvantonline, cancermath and predict don't give recurrence/mortality percentages for radiation. How much does radiation improve our chances?

I have Li Fraumeni syndrome, which increases my chances of new cancers by a higher percentage than for others without LFS, but it's unclear by how much. I'm considering skipping rads altogether.


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  • 09bankr
    09bankr Member Posts: 1
    edited May 2015

    Saw my Rads onc on Monday. He said rads lowers risk of recurrence by two thirds. Said risk for all women with all types of BC is 20-25% so that means it cuts risk to roughly 7-8%.

  • Cheesequake
    Cheesequake Member Posts: 264
    edited May 2015

    Wow, that's a big improvement. That makes it a very difficult decision. Thanks 09bankr.

  • Cheesequake
    Cheesequake Member Posts: 264
    edited May 2015

    Just wanted to update this thread with more information in case other people are seeking it out. I found a couple studies with some good info:

    Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: After breast-conserving surgery, radiotherapy to the conserved breast halves the rate at which the disease recurs and reduces the breast cancer death rate by about a sixth. These proportional benefits vary little between different groups of women. By contrast, the absolute benefits from radiotherapy vary substantially according to the characteristics of the patient and they can be predicted at the time when treatment decisions need to be made.

    Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: After mastectomy and axillary dissection, radiotherapy reduced both recurrence and breast cancer mortality in the women with one to three positive lymph nodes in these trials even when systemic therapy was given. For today's women, who in many countries are at lower risk of recurrence, absolute gains might be smaller but proportional gains might be larger because of more effective radiotherapy.

    This second study was boiled down to me by Dr David Gorski as follows: "Post-mastectomy radiation therapy is associated with a decrease in risk of local recurrence over 10 years from 26.8% to 8.1%, whereas in women with node-negative disease the difference is not statistically significant."

  • Italychick
    Italychick Member Posts: 2,343
    edited May 2015

    the numbers don't make sense to me. My MO said with surgery only, chances about 70-75%. Adding chemo she said gave me another boost to about 85-90%. So I am having trouble with the radiation increase because that would put me over 100%. I started another forum looking for research on lumpectomy/rads vs. mastectomy.

  • Cheesequake
    Cheesequake Member Posts: 264
    edited May 2015

    I was shocked to hear that the risk of local recurrence is 26.8% with a mastectomy, 8.1% with mastectomy and radiation. Really? I thought mastectomy alone has a 5% risk of local recurrence - because there isn't much place left for it to recur!! I'm so confused....

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