Fermara (Letrizole)

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Just finished chemo 3 weeks ago and now starting fermara. Can anyone tell me what to expect and what side effects you may have gotten?

Thanks for any info.. little nervous about starting it.

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  • Hopeful82014
    Hopeful82014 Member Posts: 3,480
    edited February 2015

    Thinking Positive - Congrats on finishing chemo. I hope you're starting to feel more like yourself again.

    Experiences vary widely with all of the AIs, so yours may be very different from mine:

    I've been on it since mid-October. So far I've had no real side effects - some maybes, but nothing definite. I had a few weeks of some breast tenderness that my PA said could have been related to Femara. She said that usually is transitory - and that's been my experience. I have had none of the stiffness or sore joints some women talk about but it is demonstrated that exercise helps reduce those effects, and I'm very consistent in my fitness program. My hair seemed a lot drier at first but I'd also been traveling a lot AND the weather was very cold and dry, so I won't chalk that up entirely to the drug.

    I think the first month or so you could see some adjustments - maybe feeling down a bit more than expected, feeling a bit out of synch with your body as it adjusts to the changes. I know many women though who do great on Femara, as I have, and for whom it's pretty much a non-issue.

    I take it just before bed so that if there are any issues with wooziness or tiredness they won't cause problems; once I'm in bed tiredness is welcome. It's also easy for me to remember at that time of the day.

    I hope you adapt to it easily and are very responsive to it. If it works for you it can be a really great tool in preventing recurrence as well as dealing with anything that might have survived chemo.

    Feel free to ask if you have any other questions.

  • ThinkingPositive
    ThinkingPositive Member Posts: 834
    edited February 2015

    Still not feeling 100%, get very tired, achy, taste not back completely. How does it make you feel? Concerned since it said can cause dizziness. Is it best to take in the morning or at night? I was told anytime, but just wondering if its better taken at night?

  • Kat-ski
    Kat-ski Member Posts: 212
    edited February 2015

    I am now taking letrizole after taking Armidex for a year or so. My doctor said to start letrizole 2 months after stopping Armidex. About three weeks of no AI.s, my backache went away. I tried taking letrizole at night but it reacted with my ambiem and my sleepless nights returned. I am taking letrizole when I get up and it does tire me but the backache did come back but it is better than before. When Spring arrives, it will be better for me as SAD gets bad in Feb. I do get the prollia shot to strengthen bones every 6 months. I just dislike the fact that all of the issues BC has given all of us. We just have to stay strong! My husband has been my main support but he is having heart-health problems now. I feel helpless because my trust in doctors are questionable and I have to support hubby in his decisions. Take care everyone!! Kat



  • ThinkingPositive
    ThinkingPositive Member Posts: 834
    edited March 2015

    Katski. thanks for the info. I see you also had radiation, what was the reason you needed to have radiation, if I may ask? Hope everything is okay with your husband.

  • Kicks
    Kicks Member Posts: 4,131
    edited March 2015

    I have been on Femara then letrozole for 5+ yrs with no issues (will be on it 'forever'). When I started, Femara was not available as the generic form letrozole. As soon as it was available in generic form, I went to letrozole. Have been on several different manufacturer, can't say I've seen any difference in them.

    I started Femara a week after starting Rads. I started Rads a week after last Taxol.


  • Hopeful82014
    Hopeful82014 Member Posts: 3,480
    edited March 2015
    Thinking Positive - I imagine getting over chemo takes a while but hope that most days are starting to feel better? Wouldn't it be nice if they could tell you when your taste will return to normal, etc.? Dizziness or light-headedness can be a SE of Femara but it's not something I've encountered. I do take melatonin at night as I've had sleep issues for years - long before cancer. I just haven't noticed any real difference with Femara with anything, really. It is bound to be better than chemo or radiation.
  • ThinkingPositive
    ThinkingPositive Member Posts: 834
    edited March 2015

    Thanks Hopeful8201...today is the first day I have felt somewhat better since chemo on Feb 5th. After reading your reply and a few others, I guess I will take before bed. Little bit nervous about taking it and what to expect, but as you said...it has to be better than chemo!!

  • Kicks
    Kicks Member Posts: 4,131
    edited March 2015

    Kat-ski - What do you do for your SAD? I've kept my SAD under control for many yrs with starting using my light box in Sept until May. I also increase my D supplements during that time.


  • Kat-ski
    Kat-ski Member Posts: 212
    edited March 2015

    Thinkingpositive: Radiation was just part of the whole treatment plan to search and destroy any funky cells. I had it twice. First in Canada on my left side(2006) for 15 days. The right side was stage 3 ILC so the standard procedure in Michigan is for 5-6 weeks. I questioned this as 15 days was very easy to do. But the team here said 33 days and I only had 28 days due to tissue expanders being removed so there were no markers for the boost. Looking back on on it now, I wish I just said enough at 15 or 20 days because my skin totally burned from the inside out 3 days after I finished. From reading it looks like the short-term is being considered more even if it is stage 3. I was told that I could not have radiation anymore.

    Kicks: I always have a very bright living room with all of the lights on all day. In the summer, I get more sun in the living room so I don't use the lights until the trees stop the sun coming in. I also take seroquel every night as I have bi-polar. I can feel the SAD mostly in February. I have just learned to cope with the moods. It has been challenging this year due to the fact my daughter and her two boys(4 and 2) moved in our bungalow in August. The noise levels get way too high at time.

  • Hopeful82014
    Hopeful82014 Member Posts: 3,480
    edited March 2015

    So you found the shorter course not just easier in terms of the time commitment, Kat-ski, but also as far as side effects? Do you recall if the total dosage was the same?

    Thanks for any additional info - and I hope you start getting some sun soon!

  • fizzdon52
    fizzdon52 Member Posts: 568
    edited March 2015

    HI there, just thought I would add that here in NZ I only had 15 radiation therapy treatments and 5 boosts (20 treatments all together). I also had mepitel film used so had no burns what so ever. My skin remained just as it was before radiotherapy. I have just come off Femara after over 6 months. I started off really well on Femara and could put up with side effects. However my blood pressure started going up really high (193/90 was the highest), and I have also been having terrible palpitations, vaginal bleeding and been feeling so unwell so my Oncologist has taken me off it for 2 months. I am probably going onto another one once they figure out what is going on with me.

  • Hopeful82014
    Hopeful82014 Member Posts: 3,480
    edited March 2015

    Fizzdon, I don't want to hijack the thread but am interested in your experiences with mepitel, as I've seen references to it by other Kiwis.

    Did you have any long-term or permanent change to the color of your skin? (For example, a permanent tan on the radiated side.) What about changes to the firmness of the breast itself? Did you cover the skin with mepitel at the start of radiation and just leave it on until the end or did you have to re-apply it on a regular basis? It doesn't sound as though you used any other lotions or treatments - just the mepitel?

    Thanks for any additional info you'd care to provide. I wish you much better results with your next A/I and that you'll be feeling better soon.

  • Nomatterwhat
    Nomatterwhat Member Posts: 587
    edited March 2015

    Kat-ski and Kicks -- does SAD have to do with sun deprivation? 

  • fizzdon52
    fizzdon52 Member Posts: 568
    edited March 2015

    Hi Hopeful, they applied it before my first treatment from memory. It's kind of like cling film (we call it glad wrap here in NZ). I don't have any kind of tan on my skin, my freckles haven't changed (I am very pale). The firmness is exactly the same as the other breast. In fact you would hardly know I had even had radiotherapy. I still have a slightly blue nipple a year out from surgery, so that and my scars (and a slightly smaller breast) are the only signs that I've had breast cancer. It is amazing stuff. Most of it stayed on the entire time, despite showering every day. The only part that came off a few times was the part they put over my cleavage. I don't know why but that bit just didn't want to stick. By the end (after 20 treatments) it was looking a big raggedy and I couldn't wait to peel it off myself. Wonderful stuff and I can't understand why more countries aren't using it. I didn't use any other lotions, although I got some heat bumps between on my cleavage area towards the end, not blisters but tiny little heat bumps, kind of luck heat rash so they gave me some ointment for that, but I think I only used it once. Hope this helps. By the way - I had cellulitis which put me in hospital me a couple of weeks after surgery so they stuck it around that wound and I had no problems in that area either.

  • Hopeful82014
    Hopeful82014 Member Posts: 3,480
    edited March 2015
    Thank you - that truly is helpful. I'm so glad it all worked so well for you and hope that it continues. I am definitely going to have a discussion with my RO about it. Good luck getting the endocrine therapy straightened out. Take care.

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