Aromasin is a beta blocker that can caused me to be hypothyroid

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pil
pil Member Posts: 315
hey peeps. After years on Aromasin I come to understand why I am hypo.

Just be aware of this. Now I am having to deal with this issue.

Comments

  • Sydneyluv
    Sydneyluv Member Posts: 26
    edited February 2015

    Dear Pil, Aromasin is not a beta blocker, so I'm not sure I understand your question. It sounds like you need to talk this through with your oncologist or primary care Doc. Best of luck to you

  • MelissaDallas
    MelissaDallas Member Posts: 7,268
    edited February 2015

    Thyroid disease is very common in aging women. The Exemestane studies showed no appreciable affect on thyroid function:

    Other Endocrine Effects: Exemestane does not bind significantly to steroidal receptors, except for a slight affinity for the androgen receptor (0.28% relative to dihydrotestosterone). The binding affinity of its 17-dihydrometabolite for the androgen receptor, however, is 100 times that of the parent compound. Daily doses of exemestane up to 25 mg had no significant effect on circulating levels of androstenedione, dehydroepiandrosterone sulfate, or 17-hydroxyprogesterone, and were associated with small decreases in circulating levels of testosterone. Increases in testosterone and androstenedione levels have been observed at daily doses of 200 mg or more. A dose-dependent decrease in sex hormone binding globulin (SHBG) has been observed with daily exemestane doses of 2.5 mg or higher. Slight, nondose-dependent increases in serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels have been observed even at low doses as a consequence of feedback at the pituitary level. Exemestane 25 mg daily had no significant effect on thyroid function [free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH)].


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