Antibiotics, mitochondria and cancer treatment

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Some antibiotics might be a useful anti-cancer treatment because of their effects on mitochondria (energy producing organelles in cells, abundant in cancer cells, and descended from free-living bacteria).

http://www.sciencedaily.com/releases/2015/01/150128081957.htm

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  • JohnSmith
    JohnSmith Member Posts: 651
    edited January 2015

    This was an interesting read.

    Resistance issues might be a problem though. Some low-grade hospital bugs (bacteria) are now resistant to all antibiotics.

    In the lab, science has identified 15-20 known mechanisms of drug resistance with cancer. How this plays out with antibiotic resistance is beyond me.

    Lets hope this leads to new therapies though.



  • Lojo
    Lojo Member Posts: 303
    edited January 2015

    That's a very interesting point. Presumably, mitochondria aren't rampantly sharing gene bits with each other, the way bacteria do, though possibly they might within a cell, it seems less likely between cells. I know some of the mitochondrial genes are actually now in the nucleus, and not solely within the mitochondria themselves. If you haven't read about how trauma triggers sepsis via massive release of mitochondrial proteins, see if you can find those articles. Mitos are still similar enough to their bacterial kin that the immune system goes nuts when a lot of mt proteins are outside the cells. I need to think about the interplay between bacterial resistance and mitochondria more.

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