This anti-inflammatory drug kills breast cancer stem cells!

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heartnsoul76
heartnsoul76 Member Posts: 1,648
edited January 2015 in Clinical Trials, Research News, Podcasts, and Study Results

Breast cancer cell replication can be blocked by a drug used to prevent organ transplant rejection, according to a study conducted by scientists at the University of Michigan Comprehensive Cancer Center.


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  • heartnsoul76
    heartnsoul76 Member Posts: 1,648
    edited January 2015

    The rest of the article:

    'For the study, Max S. Wicha, MD, distinguished professor of oncology and director of the U-M Comprehensive Cancer Center, and colleagues identified a receptor on cancer stem cells which, in response to inflammation and tissue damage, triggered growth of stem cells. Additionally, the research team reported that repertaxin, a drug used to prevent rejection after organ transplant, not only blocked the receptor that triggered cell growth, but also killed breast cancer stem cells and prevented cell metastasis in the mice that they studied.

    "Developing treatments to effectively target the cancer stem cell population is essential for improving outcomes. This work suggests a new strategy to target cancer stem cells that can be readily translated into the clinic," Dr Wicha noted.

    The results revealed that mice treated with repertaxin or the combination of repertaxin and chemotherapy had dramatically fewer cancer stem cells than those treated with chemotherapy alone. Furthermore, repertaxin-treated mice developed significantly fewer metastases than mice treated with chemotherapy alone.

    "These studies suggest that important links between inflammation, tissue damage, and breast cancer may be mediated by cancer stem cells. Furthermore, anti-inflammatory drugs such as repertaxin may provide a means of blocking these interactions, thereby targeting breast cancer stem cells," Dr Wicha concluded.

    The study's findings were published in the Journal of Clinical Investigation (Epub ahead of print).'

    I want it available NOW!

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  • JohnSmith
    JohnSmith Member Posts: 651
    edited January 2015

    Awesome.

    Where's the link?

    Thanks.

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  • SpecialK
    SpecialK Member Posts: 16,486
    edited January 2015


    http://www.jci.org/articles/view/39397

     

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  • JohnSmith
    JohnSmith Member Posts: 651
    edited January 2015

    ok, cool, but that link refers to an article published in 2010.

    Is this supposed to be new research?

    confused... :|

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  • heartnsoul76
    heartnsoul76 Member Posts: 1,648
    edited January 2015

    Sorry, John. It is from 2010 - I saw it on Oncology Nurse Advisor. I plan to ask my oncologist if she knows about this study and if she has or will prescribe the repertaxin. I don't know if there is anything more recent on this.

    Ah, another article from 2012: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294043/

    Thanks for that great link, SpecialK!

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  • macygrace
    macygrace Member Posts: 205
    edited January 2015

    I just don't have time to dig into this any further right now, so have at it!

     

    http://clinicaltrialsfeeds.org/clinical-trials/results/term=repertaxin

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  • SpecialK
    SpecialK Member Posts: 16,486
    edited January 2015

    I looked at the study linked in macy's post - looks like only one would apply to breast cancer - and it is a window of opportunity pre-surgery trial.  It also looks quite limited as they anticipated enrollment is only 40 patients.

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  • glennie19
    glennie19 Member Posts: 6,398
    edited January 2015


    heartnsoul:  it is not commerically available. Still in Clinical Trials.

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  • heartnsoul76
    heartnsoul76 Member Posts: 1,648
    edited January 2015

    Well, I guess I'm glad they're being thorough.

    Just wish they would be that thorough before they approve all the things happening to our food that can actually CAUSE cancer. Sigh...

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