Here's what cheezed me off today

Purple, I had a really low moment today thinking about all the screw ups.

SAS
I soooooooooooo can relate !  Sure been there. I do a whole lot of " Monday morning quarterback" stuff which of course is not good at all.

At one time, I had an entire closet full of MRIs, test results,  etc ... from the past 15 yrs  ( My health went downhill with odd symptoms round that time-  I was 41.)  I trashed all of it last yr., and it still bothers me sometimes!

If all DRS treated their pts. the same way they would treat their own daughters or wives etc ... a whole lot more of us might be better off! I have an appt. with PCP for my ' mystery rash ' today - sure hope he listens.

Take Care , sas.

Hugz

SAS

I've just had soooo many firggen things happen which I have had to find "Novel" ways to treat them b/c standard treatments aren't working or dx may be done by another method.

I understand * all too well*!  Had to DX myself and usually drs. get very pi$$ed off when you do  ( hey, someone has to! )  he listened today, agreed with my DX and  helped.  Still wish I had all those old records!

sas

chronic uticaria caused by  sudden change in body temp /going into chilly pool. Problems with thermoregulation.  I have an autonomic disorder .  Also flared last summer when I tried to exercise until I stopped it all ( exercise induced uticaria. )  NOBODY could figure it out.  many tests and angst.

Doesnt sound like much , but lasted 5 mos. and with LE, skin was compromised, had to basically sit out the summer and now , here we go again.  Can get quite serious where one can go into shock...stupid me going into the pool again, but I did not know.    MY BP is extraordinarily low and ESP now as I have given up the saltshaker since my friend lymphedema joined me.

As for records, I'd like all of them!

Think I could have buily a lawsuit somewhere along the past 15 yrs. but then ...  who would be my DR?

sas

Not too sure what you are talking about,  but I will hunt around.

THX

  * Found it !  thanks.  Intriguing,  but not too similar to my case.  Mine stems more from terrible circulation, very very  low BP and DYSAUTONOMIA.

Exercised induced urticarial ---Light bulb!...........Seems to me , I knew some one ........It involves Histatmine.  Okay Autonomic stimulation somehow triggers  the  allergic cascade. At least a dozen steps. Interesting. Last I'd heard of it they hadn't made it beyond the histamine. (very long time ago). Now they've made it to autonomic control. Well that's nice. I'm assuming sympathetic versus parasympathetic.  ??????? ANS stimulates an allergic cascade---no shit. 

An allergic cascade only means that the steps of an allergic response have started. I'll say dozen or so. Benadryl is used to interrupt the step that releases histamine. Epinephrine is used to interrupt- LOL I forget. But it's late stage. Reverses the critical occurrences in an allergic response i.e. bronchospasm, blood vessel dilation which leads to collapse of blood pressure.

ROTFLOL-----that's the beta response. So, I remember part , but not all i.e. what stimulated the beta response. Probably wasn't funny to you .

But the allergic response is usually associated with an antibody --antigen contact. Antibody---body recognizes a foreign substance   i.e antigen. Antigens are protein based.

 The Body develops antibodies after being exposed to something that has  triggered the immune system. The why of triggering is still unknown---or maybe I haven't kept up. But if the why were known , we would be doing something about it. Since allergies are skyrocketing i.e.peanut allergies, I would say we haven't got a clue yet.

For example, bee sting first time---won't illicit a response, b/c antibodies haven't formed. Then antibodies may form and the 2nd sting  causes an allergic cascade from minor localized response , up to an including anaphylaxsis. Usually most people have heard of someone getting stung the first time and going into anaphyllaxsis. But there was a prior exposure thru inhaling bee dust. Hope that was a decent example.

I know there has been oodles of research re: allergies in kids and exposure to foods at an eraly age can lead TO ALLERGIES----LOTS MORE STUFF.... But

Purple, What have you found re: ANS stimulating the immune response

In a younger time, I'd get my adrenaline going and research the hell out of it. But my adrenals now just say F*ck-it

Going to go play

Purple, maybe this will help your study. Most of the bodies systems(7) have a "negative feedback mechanism" That allows the system to check if it's working.  Say the control is A. A sends a message to BCD to do something. EFG senses whether BCD are doing their job. E, F, G all sense something different. They independently send messages back to A. A decides what to do. If B,C, or D aren't performing right A sends out another message. A >>>BCD>>>EFG>>>A>>>BCD>>>EFG>>>A>>>etc.  It all happens rapidly and continuously. Until something interferes.

"blood vessel dilation which leads to collapse of blood pressure...."  " the vasodilation causes all the blood to pool to the extremeties "   First a description of the vascular circuit>>>heart>>Aorta(artery, slang Big Red) >>branching arteries>>arteriole>>capillary>>venule>>vien>>Vena Cava(vein, big Blue)>>Right heart>then lung circuit>then left heart.

The arteriole is responsible for constricting or relaxing which will increase or decrease  the pressure. Analogous to a garden hose with thingy on the end that you turn to change flow. Lol can't think of word.  When the arteriole doesn't work right then pressure changes can cause problems. If it constricts without responding to A's messages to relax, it results in too much tension in the line. i.e hypertension. Conversely, if the arteriole relaxes too much, there's too little tension in the line i.e. hypotension

In the case of the vascular system ---hypertension= high blood pressure, hypotension= low blood pressure. The arteriole is responsible for the changes. The ANS is responsible for changing the tension on the arteriole.

There is a pressure gradient in the vascular circuit. The arterial pressure is higher then the venus pressure. If the arteriole malfunctions and dilates the pressure within the capillary changes. This allows leakage of fluid from the capillary into the space outside the capillary. This fluid can flood the space outside the vascular circuit.  This happens in certain conditions i.e ANS dysfunction; Septic shock; Drugs that are meant to lower BP, but are working beyond what they are meant to do, infection, immune response

 If the pressure in the venus side changes by becoming to high, then it can reverse the flow by changing the pressure in the capillary . The capillary can't withstand the pressure and the fluid floods out into the space outside the vascular system.

Increased capillary permeability is the official wording. Causes>>changes in either pressure gradient from the arterial side or venous side. Changes caused by drugs. Changes caused by chemicals either internal, or external.

Flooding from the capillary can occur b/c of two different reasons. Either the arteriole failed/changed, or the venous system pressure was too great and back flowed.

Work to understand why the arteriole fails

What drugs are you on.

When edema occurs in the lower  extrmeties or anywhere, it creates a logjam. When the logjam occurs nothing flows right. Other structures are compressed because there too much pressure on them from the extra fluid.

A river logjam is an excellent analogy. Logs pile up the river stops flowing. The river banks overflow. What is around the river is covered. Say there was a pumping station that usually filtered the water from the river to be taken and cleaned to be dumped back into the river. The pumping station can't work right. It no longer is filtering the water from the river.

The logjam creates the flooded area, the pumping station can't get the gunk out of the water. It all is a mess. All this stuff just stagnates. Things start to grow.  The growing stuff affects the things around it.

The bodies usual protective mechanism is the lowly lymph system. The reason I say lowly lymph system is people in general don't know about the lymph system. The high and mighty nervous and cardiovascular system, even grade schooler's can talk about. But the lowly lymph system is ignored until something goes wrong.

The lymph system is analogous to the filtering pump station in the logjam example. The lymph system filters i.e. cleans the area around the cells, picks up the garbage thrown out by the cells, moves it to the transport system i.e. lymph network. The lymph fluid is taken to the lymph nodes which further cleans up the garbage. The fluid then continues from the lymph node and is transported to the thoracic duct where it's dumped back into the vascular system.

With edema, the lymph pathways can be compressed. It can't pick up the waste products that the cells throw out, and carry these waste products away. Those waste products can cause multiple problems, infection-cellulitus, rash associated with bodies immune response to stuff that's irritating cells.--release of histamine which causes an itch.

This is an area to study purple --"what is the bodies response when edema occurs". Hope some of this helps

Yay!!  Nips up one and all!  My boob check came back clean.  Whatever microcalcifications they saw 6 months ago are no longer there.  And to think they wanted to biopsy and disrupt the inners of my breast.  This just goes to show that sometimes you have to be your own advocate.  I even picked up my disk and when I looked at it this afternoon, I could see the calcs from last time kinda came together to make just a regular macocalcification.  The doctor said I was good for 1 year.  No more 6 month scares.  Happy Mother's Day!  When mom is happy, everyone is happy!

Accept is it mammo or MRI?  If mammo & mri rejoice.

Purple you are a perfect person to get on the bandwagon of genetic testing for drugs---------- i'll bring back the link, start with my posts in feb2014.

You have do to allot of study in order to protect yourself.

https://community.breastcancer.org/forum/73/topic/798301?page=6#idx_175

This last  post is a repost to protect yourselves---Ocd me trying to protect everyone sassy

Thanks everyone for the positive thoughts.  I was able to have a great mother's day knowing that my boobs can rest easy for another year... of course the mini paranoid voice in my head was thinking, hey is this really good that they are not looking every 6 months anymore and what about the scare that film reading doc put me through only to find it was nothing.  I crack myself up sometimes.  My new song for the year...

Let it go, let it go, I can make myself insane,

Let it go, let it go, I'm not in any pain,

Here I am with my boobs okay... Let's get on with life... 

There's always more shit anyway!

Hi, popping in. I was posting with another member. I thought sharing the below information may be helpful to you .

The link www.needymeds.org is to a web site started by a Social Worker and a doc. It is a tricky site to use. The first page leads to a several hundred resource pages. But I think this first page, does not project the wealth that lies beneath. Be patient when following the links within the site. There are sections that are disease and drug specific. The specific page then links to lists of organizations that provide monetary or other types of assistance.

Register first and do the request for assistances form. Reason: the request for assistance form is filed. If you apply to 1 or 20 organizations/companies, the forms don't need to be repeatedly filled out.  The system is designed to pull information from the original form. There may be a few particulars that need to be added to a companies/organizations form.

All the pharmaceutical companies have patient assistance programs. All the drug manufactures are listed there

The other way to reach drug manufactures is 1. call the manufactuer patient assistance number(goolge keywords: drug name and manufacturer, then to webpage>>>patient assistance. Very time consuming.

There is so much more on www.needymeds.org. It took a bit of time to wander through the whole site. I've shared a telephone walk through with many friends and relatives. I even called healthcare facilities to tell them about this link.

For completeness, there are many ways to get financial assistance for whatever you need. There are organizations that will do things for you i.e volunteers that buy groceries, drive, install handrails, build wheelchair ramps.

How to find the info besides from the link above?  FIND the SOCIAL WORKER(SW).  It's there job to know these things   Talk to all of the following 1. cancer center SW,  2.hospital SW, 3. Insurance companies SW, 4. County SW. 5. church outreach leader.

I requested from my insurance carrier, a consult with a SW. That one appointment with the insurance carrier Social Worker, led to grants totaling $10,550. The meeting with the cancer centers SW, led to coverage of neulasta  for $4000.00.

sas, what the heck did you write.... naughty stuff?