Results of Vitamin D Study

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mike3121
mike3121 Member Posts: 410
edited June 2014 in Clinical Trials, Research News, Podcasts, and Study Results

Here's a link (sometimes my links don't work) to a short article about
Vitamin D and Breast Cancer. It doesn't refer to Vitamin D2 or D3, as to which
is better.

http://www.foxnews.com/health/2014/03/07/vitamin-d-linked-to-improved-breast-cancer-survival-rates/?intcmp=latestnews

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  • Moderators
    Moderators Member Posts: 25,912
    edited March 2014

    Mike - try posting your link again

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  • besa
    besa Member Posts: 1,088
    edited March 2014

    I think this should be the link to the original article. The abstract is also below.


    http://ar.iiarjournals.org/content/34/3/1163.full

    ANTICANCER RESEARCH 34: 1163-1166 (2014)"

    "Meta-analysis of Vitamin D Sufficiency for Improving
    Survival of Patients with Breast Cancer"
    SHARIF B. MOHR1, EDWARD D. GORHAM1,2, JUNE KIM1, HEATHER HOFFLICH2 and CEDRIC F. GARLAND1,2


    "Abstract. Background/Aim: To determine whether higher
    serum 25-hydroxyvitamin D [25(OH)D] at diagnosis is
    associated with longer survival of patients with breast cancer.
    Materials and Methods: A meta-analysis was performed of five
    studies of the relationship between 25(OH)D and mortality
    from breast cancer. A pooled hazard ratio was calculated
    using a random-effects model. The Der Simonian-Laird test
    was used to assess homogeneity. Results: Higher serum
    concentrations of 25(OH)D were associated with lower casefatality
    rates after diagnosis of breast cancer. Specifically,
    patients in the highest quintile of 25(OH)D had approximately
    half the death rate from breast cancer as those in the lowest.
    Conclusion: High serum 25(OH)D was associated with lower
    mortality from breast cancer. Serum 25(OH)D in all patients
    with breast cancer should be restored to the normal range (30-
    80 ng/ml), with appropriate monitoring. Clinical or field
    studies should be initiated to confirm that this association was
    not due to reverse causation."

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  • Anonymous
    Anonymous Member Posts: 1,376
    edited March 2014

    Heres some excerpts on VitD Ive kept on my HDD. At the time I didn't put the source links in where I got the info, but it shouldnt be hard to verify.

    25-hydroxyvitamin D blood test (25(OH)D blood test)
    Test that measures the amount of calcidiol circulating in the blood. The most accurate measure of the amount of vitamin D in the body. See blood calcidiol level.

    Blood level or blood calcidiol level
    The amount of 25(OH)D (calcidiol) circulating in the blood. For proper health, blood calcidiol levels should begin at 125 nmol/L (50 ng/mL), with optimal ranges from 125–200 nmol/L (50–80 ng/mL). When someone refers to vitamin D blood level, they are referring to blood calcidiol level. see 25-hydroxyvitamin D test.

    Calcidiol
    25(OH)D (25-hydroxyvitamin D). A prehormone in your blood that is produced in the liver from the metabolism of vitamin D3 cholecalciferol. When testing for vitamin D deficiency, this is the only form that should be tested for.Calcitriol
    1,25(OH)2D3 (1,25-dihydroxyvitamin D). Referred to as activated vitamin D, calcitriol is the most potent steroid hormone in the human body and has powerful anti-cancer properties. Calcitriol is made from calcidiol in the kidneys and other tissues and is also produced synthetically as an analogue. Calcitriol levels should never be used to determine if you are deficient in vitamin D.

    Cholecalciferol
    Vitamin D3. Cholecalciferol is the naturally occurring form of vitamin D. It is a prehormone that is synthesized naturally in the skin by ultraviolet B irradiation of 7-dehydrocholesterol. Cholecalciferol is real vitamin D. All other compounds are either metabolic products or chemical modifications.

    Vitamin D
    A prohormone that behaves similar to a steroid in that it binds to a receptor and has a regulatory effect on gene expression. Vitamin D plays an important role in: the maintenance of several organ systems, bone formation and mineralization, and the control of calcium and phosphorus metabolism. Vitamin D also performs immunosuppressive and anti-tumor functions and is vital for the maintenance of the blood/brain barrier. The term vitamin D also refers to vitamin D metabolites and synthetically-derived vitamin D analogues.
    Different forms of vitamin D:
    Vitamin D1: molecular compound of ergocalciferol and lumisterol (1:1 ratio).
    Vitamin D2: ergocalciferol or calciferol (made from ergosterol).
    Vitamin D3: cholecalciferol (made from 7-dehydrocholesterol). Vitamin D3 is real vitamin D. All other compounds are either metabolic products or chemical modifications.
    Vitamin D4: dihydrotachysterol 22,23-dihydroergocalciferol.
    Vitamin D5: sitocalciferol (made from 7-dehydrositosterol).

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