Neew hormone receptors to target when treating breast cancer

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cp418
cp418 Member Posts: 7,079
edited June 2014 in Clinical Trials, Research News, Podcasts, and Study Results

http://www.sciencecodex.com/researchers_discover_new_hormone_receptors_to_target_when_treating_breast_cancer-127326

Researchers discover new hormone receptors to target when treating breast cancer


 

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  • SelenaWolf
    SelenaWolf Member Posts: 1,724
    edited February 2014

    "Interestingly, these eleven normal breast cell types were categorized into four new hormonal differentiation groups (HR 0, 1, 2, 3), which were characterized by vitamin D, androgen and estrogen hormone receptor expression. "

    Interesting.  So, does this mean that they suspect breast cancer cells feed off Vitamin D?  And, if they do, what does the Vitamin D do: shut down growth or spur growth?

     

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  • cp418
    cp418 Member Posts: 7,079
    edited February 2014

    http://guardianlv.com/2014/02/breast-cancer-revelation-other-hormone-receptors-could-be-targeted-for-novel-therapies/

     

    "Other studies have shown that vitamin D and calcium play a role in regulating cell proliferation and death, in both healthy cells and breast cancer cells; many researchers have conjectured vitamin D to be capable of offering anti-carcinogenic properties that protect against breast cancer. The active form of vitamin D can bind to vitamin D receptors and prevent cell proliferation; the pro-hormone can also prevent growth of new blood vessels that feed malignant breast cells the nutrients required for continued growth."

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  • besa
    besa Member Posts: 1,088
    edited February 2014

    CP418 thanks for posting this.  Very interesting. 

    I have posted a link to (hopefully) the full text of the original article.

    http://www.jci.org/articles/view/70941

    They are postulating using estrogen receptor antagonists (an antagonist blocks and prevents normal signaling-- tamoxifen is an antagonist in breast tissue),  but for the other two receptors --the Vitamin D receptor and androgen receptor they are proposing using agonists (a drug that would bind and signal -- turning on the receptor) to treat breast cancer.

    "Response of breast cancer cell lines to HR inhibition. The HR0–HR3 classification of breast cancers not only correlated with clinically significant outcome groups, but may also provide insights about how the treatment of these patients might be personalized. For example, we envisioned that HR3 tumors might be treated using triple-hormone therapy (ER antagonists plus AR and VDR agonists), and tested some of these concepts in breast cancer cell lines."

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