Drug to reverse breast cancer spread in development
Comments
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this is good news, thanks:)
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Sounds good.
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I've been scouring the web for more info on this but haven't found much except for what the above articles are saying and I'm unclear. When the gene was supressed, the mice didn't develop mets? How would they know it wouldn't have without the gene supression? Or, they already had metastatic disease and it remained stable? Also, could happen without the gene supression. The only thing I didn't see clearly spelled out is that the mice already had metastatic disease, but showed regresssion. If that's the case (and maybe I'm just not seeing it), that would be awesome, but the other two scenarios don't really excite me. If anyone has more info, I'd be really interested in hearing about it.
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http://www.walesonline.co.uk/news/wales-news/welsh-scientists-developing-treatment-prevent-6594333
"In recent studies, researchers identified a critical role for a potential cancer causing gene, Bcl3, in metastatic breast cancer.
In their current research, the team at Cardiff University are looking at ways to suppress this gene through treatment.
Using computer-aided modeling of how the Bc13 gene works, the group identified a pocket on the surface of the gene that is essential for its function.
They then identifed a drug that could inhibit the way the gene works.
When the compound was trialed on mice with metastatic disease, researchers found the drug completely stopped the development of the mice’s metastatic tumours.
The team are now working to test the compound in clinical trials with the aim of developing a treatment that can block metastatic disease in breast cancer and a variety of tumour types."
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I did read that. "When the compound was trialed on mice with metastatic disease, researchers found the drug completely stopped the development of the mice’s metastatic tumours". From that, I assumed the mice had metastatic disease and did not progress. My issue is that even us humans with metastatic disease sometimes don't progress for years, so I'm wondering how they know it's due to the gene supression therapy or if that would have been the case anyway. Guess I'll find out as more info becomes available. Thanks for the info cp. Always appreciate your posts.
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Guess what I'm hoping for, is somewhere down the road, the term "regression" is used.
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I've been trying to find out the name of the drug so I can keep an eye out for clinical trials, but so far I find almost nothing but more links with the exact same wording as the links in the original post. I did find one other article here which says the work was published online on January 26, 2014 in Cancer Research, with a link to the journal, but the most recent articles I saw on the Cancer Research Journal website (in the OnlineFirst section) are dated Jan 23. Very mysterious.
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There is no drug developed yed. Tiziana pharmaceuticals is trying to develop the drug.
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Wow, this would be an amazing breakthrough. Too many cancer "breakthroughs" don't make the transition from mouse experimentation to human use.
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@Srh242, the article says
"...the group identified a pocket on the surface of the gene that is essential for its function.
They then identifed a drug that could inhibit the way the gene works.
When the compound was trialed on mice with metastatic disease,
researchers found the drug completely stopped the development of the
mice’s metastatic tumours.
The team are now working to test the compound in clinical trials..."I want to know the name of what is referred to as "a drug" or "the compound" so I can look for more information and followup stories online. Since this is all happening in the UK, I don't imagine I will be able to participate in any of the clinical trials, but I would like to keep track of the further testing of this drug to see if it works on people as well as it did on the mice.
@leggo, I'd like to see the word "regression" too. The headlines use the word "reverse" but the text of the story doesn't say spread was reveresed, only that it was halted.
Another thing I'd like to know that isn't mentioned in the article...it says this compound completely stopped the development of the metastatic tumors. Do they mean permanently stopped, as long as the mice continued to receive the drug? Or is this another treatment like others, that after a while stops working?
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@curveball : the article should have said they id a substance and not a drug. For me adrug is something that has a patent.
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Check this link out: http://courses.cardiff?ac.uk/funding/R452.htm
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Check this link out: http://courses.cardiff.ac.uk/funding/R452.htm
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Probably they are not going to say the name of the compound, so they can sell it to big pharma.
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@Srh242, I copied and pasted the URL but got a "page not found" error. What is the link?
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I finally found the article in Cancer Research Journal. The title is "Bcl3 selectively promotes metastasis of ERBB2-driven mammary tumors", and it was published in January of last year. If you have access to PubMed (often available through public libraries)
there's a link to the full text of the article. I haven't read it yet
and don't know if I will understand it when I do.I guess what is new and prompted all the press releases this weekend is that Tiziana Pharmaceuticals has agreed to fund clinical trials of the drug that was tested earlier on mice.
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I can't even find a phone number for "Tiziana Pharmaceuticals".
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I found an address but no phone number. It looks like a small company. Weird.
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Looks like this pharma company is a tiny off-shoot of an investment company called BioVitas Capital.
*A UK–based biotechnology start-up company established by healthcare entrepreneur Gabriele Cerrone though BioVitas Capital Ltd., his international biotech incubator specialised in developing early stage discoveries in the biotech sector.
http://www.biovitas.com/Welcome_to_BioVitas_Capital___Home.html
I haven't had any luck getting through.
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I thought it was based in England,
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Biovitas is in Italy?
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For all I know, the pharma arm of this company is in England. There is so much about this that's ambiguous. Hopefully, they'll pick up their phone at some point.
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Yes, I will ask my english friend to find out.
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I'm going to speculate here that this is not quite a drug yet but still a "research compound". I agree it only made it into the news because this research got picked up by a biotech/pharma company willing to fund the clinical trials. Information about the drug compund will be scanty or not available for competitve reasons and because the clinical trials are still pending..... This is just my guess but hopefully we will see more in the news.
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I agree cp418
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hope its a major find ......this disease took my sister last year
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http://m.asia.wsj.com/articles/SB1000142405270230...
Here is an example of how altering genes can work in practice. The technology is there to implement if it's successful
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Apparently, the drug company is even "still in development", so I'm thinking it will be a long time before it sees the light of day. Since the compound and research is "owned" by a bio-tech company working on developing a pharmaceutical company, I'm not feeling to confident. I think money will be the deciding factor. So hope I'm wrong.
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Any news?
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