Artical on one of the Previvors groups... Dense breasts
Dr Rhodes at the Mayo Clinic, breastunit says that dense breasts cause high risk equal to women having the genes for breastcancer.
Comments
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You are misunderstanding what you are reading because that is incorrect. -
while increased breast density does make it much more difficult to see anything suspicious on mammo, it increases your overall risk slightly to moderately at most; nowhere near the very high risk of BRCA positive.
Anne -
A link/citation would be helpful. It is difficult to know the context of your statement, and if it was a direct statement from Dr. Rhodes, or if it was a statement from journalism. I tried for about 10 minutes to find a citation in Google, and I can't find one.
According to the Breast density site (kindly found by Beesie)
http://www.breastdensity.info/index.html- Approximately 50% of women undergoing screening mammography are classified as having either "heterogeneously dense" or "extremely dense" breasts. For all of these women, the patient letter will inform them that they have "dense breast tissue."
- Only 10% of all women have "extremely dense" breast tissue, which is associated with a relative risk of breast cancer of approximately 2 compared with average breast density. 40% of women have "heterogeneously dense" breast tissue, which is associated with a relative risk of approximately 1.2. Therefore, breast density is not a major cancer risk factor.
Note that in one breast cancer risk model for individuals, breast density only increased the accuracy of breast cancer prediction for individuals from about 0.59 to 0.66 (with rather large 95% confidence levels) http://jnci.oxfordjournals.org/content/98/23/1673.full.pdf -
Hi,
Dr Rhodes article was posted in a major american newspaper, I saw the printout one of the Previvors group forums.
Dont have time to give exact info. -
if you state something as fact you should be prepared to back up your statement. -
http://online.wsj.com/article/SB10000872396390444246904577573181463638846.html
Could this be the one? The article does mention "Studies" but doesn't elaborate on who did the studies or where. -
That is not correct. You are either misinterpreting or spreading misinformation. No where have I seen someone say density is on par of having a BRCA mutation.
Most women who are pre-menopausal (66%) have dense breasts, either heterogenously dense (50-75% density) and a smaller number have extremely dense breasts (75%+ density). A few (25%) continue to have dense breasts after menopause. All this means is there is a higher ratio of parenchymal & connective tissue compared to fatty tissue. As parenchymal and connective shows up white on mammograms, just like cancer, mammograms are less accurate and may lead to higher false negatives. As fatty tissue is dark on mammograms, the white of cancer is very visible.
Certainly you can see why saying 66% of premenopausal women and 25% of post-menopausal women have a LIFETIME breast cancer risk ranging from ~37% - ~85% (BRCA+ ranges) is odd and incorrect? Knowing the average risk is 12% LIFETIME risk.
There is some studies to indicate density is its own risk factor - as in not only can it hide cancer in mammograms but it can also encourage tumour growth but this may also be related to having more places to grow in the first place, or because younger and denser tissue often means more estrogen uptake, etc.
In any event it it still not a risk factor on par with a BRCA mutation.
A fourfold to fivefold risk as indicated in the linked WSJ article also does not mean 4 times the average risk of 12%, it means fourfold to fivefold of your base risk...which can be as little as 2-4%. So...your risk can still be the average of 12%....not 48%.
As someone with high risk assessment of 40% (familial) my dense breasts do mean I definitely do not trust mammograms alone, and I may have some increased risk from density, but it does not mean I take my risk of 40% and do a multiple of x3 or x4. It just means it may be an increase to my present risk and is something to take into account when screening. -
Dr. Rhodes actually says this:
But Mayo Clinic preventive medicine specialist Dr. Deborah J. Rhodes claims otherwise: “Dense breasts is a greater risk factor [for breast cancer] than having a mother or sister with the disease. The vast majority of women are capable of hearing this information and not freaking out.”
Obviously this applies to families without a known mutation and without a stronger pattern of familial cancer (such as several relatives with breast cancer).
Having ONE first-degree relative (mother, sister) is said to increase risk 2-fold (technically this is not "double the average of 12%" like some would believe) but I do sometimes see people then say risk is 20-25%. Either way, density as a "greater risk factor than having a mother or sister with disease" would still not put you into BRCA ranges. Greater risk than having an affected first degree relative can mean 8-10% (i.e. double your base risk), or it could mean 20% LIFETIME risk. It just is not clear. The first is definitely not high risk. The second would be high risk according to many guidelines (eg NCCN) but your actual 10-year risk might still only be, like, <1-2% depending on your age.
Dr. Susan Love has a great explanation of how to understand the concept of "risk" and statements like "double the risk", and the error in just multiplying the average risk when you hear such statements, in her book. -
A positive takeaway here is that MRI is the new standard for high-risk, dense breasted women thanks to these studies. It really wasn't even three years ago when I began my harrowing journey. So keep the faith, friends. I believe there will be major strides in the years ahead.
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