Here's what cheezed me off today

I wish they'd just approve the marijauana for all states. It's just creating a legal quagmire. It'll be approved within a few years anyway. The avalanche has started. Interesting that it's coming from the cancer folks.

Whats really sick is just us writing about this puts on a watch list. George Orwell was right with 1984. He was just off by a few decades. I suppose what's even more amazing is he wrote the book in 1936.

reposted from the Hot Flash forum. In the middle of this post is a reference to Freedman publishing an article specifically about Lexapro and it not being affective. I'm still trying to locate another post for you. I should be able to then find Freedmans article on Lexapro. Completely forgot about this one. So, this is cool, a study on lexapro. Freedman is one of the premiere researchers in the world on Hot Flashes.

Jul 30, 2011 12:37am, edited Aug 1, 2011 12:04am by sas-schatzi

Ren-I just don't get it -------all the breakthrough in science and brain function. AND this small thing ----in comparison to what is known , befuddles me. It is like so many other womens issues. It seemed that Freedman had made head way. I then found two other articles by him dated 2007 and 2011. Essentially updating his 2005 article, with no breakthroughs. It wouldn't surprise me if we haven't put him on a new path.

On of the things on the publish or perish thing. I learned on one job around in 1979. Is look at the bibliographies of whatever you are searching first, if you keep seeing the same articles quoted in the first few bibs. Forget what your reading and go find those articles. To much of what happens in the P&P publish and Perish scenario . Is authors are really just looking at old work and writing something. But does that something have merit. It has enough merit to get publish, but just is a rehash of old news.

 The thing that we , keep identifying as a group is the "something -Aura". All those somethings have an origin in the midbrain or brainstem. So, if that be true, I haven't seen much focus on that.

 BUT there is so much info on the internet. AND so, much is so technical that even after studying it for years, as it used to be a favorite, but I have fallen away in the last x number of years. It may seem like I'm harping on something, but their is that one little spot for each of us that starts the cascade and then we are in a full blown flash.

Let me use the clotting mechanism as an example, there are last I knew, about say 12 steps, once the body recognizes a disruption or bleed, that sends a whole cascade of things occurring to form a clot. Similarly, in an allergic response from the moment the body recognizes an antigen b/c an antibody has been formed b/c of a prior exposure, a whole cascade of events occur , again it is a dozen plus steps. All of this has been discerned by science beginning many many years ago. Drugs have been formulated for each, to interrupt the cascades at a certain point. Why we should be in such infancy stages of understanding hot-flashes, doesn't make sense.

We are still in the phase of what I call Paintball drug therapy. The drug is used and lets see if it works. Doesn't work we find another one. It's like throwing paintballs at the wall and seeing if it sticks.  Freedman did publish an article about Lexapro and that it didn't show to be effective. His comment I found interesting " We would never have done the study if we didn't think it was going to be successful." Well that is the scientific method--develop a question>>hypothesis>>procedure>>test>>evaluate results>>publish.

We are into a phase now and it is being pushed by the public with docs following rather slowly. Cytochrome 450 genetic DNA testing of liver pathways. Many pathways are recognized, but only a few have DNA testing available. It has been quite a few years that the routes /paths have been required to be in a drugs profile for the PDR and Pharmacopoeia. This is where medicine is going . When I brought up to our ONCS, mine blankly stared, My DH's said I don't even know that stuff. 6 months later they were getting training house wide.

2D6, 2,C9, 2C19. 25% of all drugs take a first pass through 2D6path in the liver. One of the biggest routes is 3A4--no test for it yet. When there is, that will change much, it will be huge. This genetic testing will show how drugs compete for the same path, whether we are slow , medium , or fast metabolizers. We will then enter a new phase of pharmacology. It will no longer be paintball therapy. We are there now, if you want to ask you doc for testing. It will be interesting to see what their responses will be. If they say it's not available. let them know that you know it is. I did and it has changed the practice of 7 docs in 4 facilities. Plus my councelor is so into it b/c after learning what it means ---he saw how it fit into how psychotropic or psych therapy drugs may or may not have worked for his patients. He is already influencing other professional in Psychotherapy in the county. It will be a domino affect. It all happened in with the ONC docs b/c I did my homework and said why can't we alter Dh's drugs during chemo b/c there are too many fighting for the same pathway. Relating frustration to the counselor, he picked up on it's value right away without any pushing.

Some may see this as a tangent---could be. But the timings right, to be on  the leading edge with your doc's. Watch their eyes, if the are blank---they haven't kept up and you are ahead of them.

Some posts ago-----can't check who said it otherwise I will loose this very pontificating/ wordy post. She said each time she explained what was happening to her her docs looked at her as if she were_______(forget what word she used to describe). I meant to write right away------the reason they reacted that way is they didn't have a clue, but didn't have the integrity to say "I don't know". I've always valued that in any person. No bluff, no dancing around the question to make you think they know. Just a simple "I don't know". I have no problem like we are trying to do here, is trying to put puzzle pieces together. That's healthy. All ideas may lead to new explorations

Well may be I'll go and look at Menopret, haven't done that yet. Glad it's working for some, sorry not for others. REN-----your Coreg response stands right up there with Clonidine, and Effexor and the other drugs doing their magic. Now if we only knew why?

Another old post that should be helpful

Jul 19, 2011 11:58pm, edited Jul 19, 2011 11:59pm by sas-schatzi

To all-have seen multiple posts re: which new thing is working. Just a phrase to add to all the other info that clogs our brains. A WASHOUT PERIOD.  This is a time when you stop one treatment and start another. In studies, this washout period can last from weeks to months. It depends on the study or drug. 8- 12 weeks, in general, is an acceptable washout period.

What the washout does is prevent giving credit or discredit for a treatment response -- bad, good or no response to the new tx.  Just as many responders have said, "I did 2-3 things different at one time, I didn't know which one is working". That's how a washout helps. When I quit Arimidex, I did a 2 1/2  month washout before starting Femara. When Femara started with s.e. within 3 weeks, there was no question in my mind they were attributable to Femara. Conversely, when the Arimidex sledgehammar hit. the  s.e. were growing for a time, but then I started Celexa. The hammer further came down within 2 weeks. I chose to quit both drugs b/c I couldn't tell which one was the offender.

When we are so desperate for a response, too many things may be changed at once. If something goes bad like an increase in s.e which drug/tx do we blame. Again , conversely, if things go well. Is it b/c of all or only one. Are we then adding something to the regimen that could have been left out. Some may say, if it's all good who cares, I'll just keep doing them all. I get that. But all drugs have consequences, we may not be aware at first what they are, but long term could be a problem. . When we run to a new tx, this must not hurt us in the long term, i.e other system dysfunction years down the road. So, just a suggestion to try and leave a washout period between new tx's. I know it easier said then done.

Consideration of a washout or lapse time between new treatments will allow a drug or tx to be able to be given full credit or discredit for a change.

This is a NIH/gov article. I likely read it in 2010-11, but DON'T REMEMBER. What caught my eye this time was the response for Gabapentin at 900mg --a decrease of 46%. So, if someone's got a neuropathy problem and hotflash problem it'd be a two for one drug. Anyways here it is

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826783/

Rohanna love you babe, but I'm now bored with the subject. Part of the ADHD that my counselor thinks I have. He says my mind isn't still clear enough to say for sure I'm ADHD. But it will suffice for now. The characteristic that he feels I possess with ADHD is that i can be extremely focused if I'm interested. Once the interest is gone, I'm done. Great excuse. Eh? Love you babe. LOL sassy

hello ladies...Thank you for welcoming me.  I just have to say even before I found out I had bc I thought the pink ribbon thing was way over done...I felt guilty like I was an uncomapssionate slob.  The when I found out I had bc I thought see what you get for having those bad thoughts!!!  I cannot tell you how amused I was when I came here to this site and so many women felt the same way. 

Ps...I tried Lexapro years ago for depression and stayed on it for two days...my DR said a side effect was losing weight.  That wasn't even enough insentive for me to stay on it!

Have a wonderful nite ladies....

Spookiesmom...lol

RC...couldn't have said it better and I work for the electric company in my state 

Spookie I'm so cheap by choice , I drove my toyota for several years in central florida east coast without AC.

Ro -dear friend would you like to ask another question? LOLOLOLOLOL took me a couple hours----way beyond what you ever cared to know. ButI know you accept me just the way I am...... L&H's sassy

PD......hey

Lovewins:)

Realty chic Welcome

Rocky good night

And I did toooooooo many years on an UN air conditioned school bus. In Pinellas traffic.

HAPPY LABOR DAY ------CHEESERS-----SASSY

Back at'cha cheezers!

Hi Cheezers!

LOL Skigirl! You go girl!

Here's what cheezed me off today:

I am trying my hardest to keep a positive outlook on everything. I have one treatment left and I have questions about all of it now that I am almost to the end. I get on Facebook and every one of my 150 friends are moaning about their lives. Cars giving them trouble, dinner going to be late again, kids in a bad mood and just ruined their day, boyfriend off to serve country and girlfriend cheats on him, brother and his wife splitting up because she didn't realize what an azz he was when she married him after living with him for 3 years, big party that was planned has been cancelled due to person having party has to work late tonight, blah blah blah...I posted on my wall "For crying out loud people, can't you just be happy for one freaking day? Life could be so much worse! I felt better Thank you very much! I how have 115 likes after posting it. LOL