P53??????Anyone here knows????????what it is?????

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netty46
netty46 Member Posts: 296
edited June 2014 in Triple-Negative Breast Cancer
P53??????Anyone here knows????????what it is?????
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  • netty46
    netty46 Member Posts: 296
    edited April 2013

    On your path reportvit mention ki67. And p53. What is it?

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  • pip57
    pip57 Member Posts: 12,401
    edited April 2013

    The p53 gene is responsible for regulating cellular growth.  If it is defective, the cells are prone to reproducing uncontrolled.  The p53 gene was involved in my teenage daughter's cancer so I was tested for the defect when I was dx with bc.  Although I have  a slight variation in the gene, they did not consider it significant enough to be the cause for my own cancer.

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  • sheilajoe
    sheilajoe Member Posts: 2
    edited April 2013

    Positive gene mutation is a considered LFS or Li Fraumeni Syndrome...

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  • tasoulla_s
    tasoulla_s Member Posts: 6
    edited April 2013

    If it says in the report p53+, what this means?

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  • netty46
    netty46 Member Posts: 296
    edited April 2013

    Not many on this board know what it is.

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  • pip57
    pip57 Member Posts: 12,401
    edited April 2013

    From my research, it looks like the + is a good thing that means there are no mutations in the gene.  Apparently, the - sign would mean that there are defects or mutations from the original gene.

    http://answers.yahoo.com/question/index?qid=20071015132620AAqztTr

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  • Charz
    Charz Member Posts: 48
    edited April 2013

    Hi pip, maybe you can answer my questions. I was recently tested for p53. My results are very confusing. 

    when my tumor was analyzed, the pathology says "Rare tumor cells were positive for p53 (<5%)"

    I am very scared of this. Im not sure how to interpret this, but i have read that p53 means that there is much more likely to recur and metastasize. Do you know if this true?

    I don't really know how bad my results are and there doesn't seem to be much info on it. It is really strange because my oncotype came back as low risk and my cancer is hormone sensitive with very low ki67, but apparently it does not take into account p53. now i am worried that i skipped chemo when i should have had it and i just dont know what to think about my future. i feel doomed. and i also read p53 can interfere with tamoxifen metabolization.

    im not sure if your doctor told you anything more about p53? its a few months before i see my doctor again and i am just sick with worry. 

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  • Charz
    Charz Member Posts: 48
    edited April 2013

    sheila, i think that li fraumeni syndrome is the familial p53 syndrome. i also think it is possible to have p53 mutation in breast cancer as well as a whole range of other cancers unrelated to the familial syndrome (the syndrome is very, very rare) whereas i read up to 20-40% of breast cancers have p53 mutation. i don't think they are necessarily the same thing. 

    this is what i read, but im not sure how much of it is accurate. there is so little information on the internet. im just not sure what the pathology report means when it indicates <5 percent in my case and what the heck that tells me... ughhh

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  • pip57
    pip57 Member Posts: 12,401
    edited April 2013

    I really don't know much more than what you posted above about the p53 gene.  My daughter was dx with a very aggressive sarcoma when she was 14 and a defective p53 gene was involved.  At the time, we were involved in a study asking questions that centered around the testing of this gene.  For example, if they could test an infant for this defect, would you want to know?  It was funny how my answer to that same question would change depending on where we were in tx.

    Fast forward to my dx.  When they discovered the family history that included my daughter, they suspected that I too carried the defect.  So I was tested.  The results came back saying that there was a "silent change" to my p53 gene that was not considered to be a factor in my case.

    I think that they are still learning more about this gene and the role it plays.

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  • slousha
    slousha Member Posts: 312
    edited May 2013

    HI,

    I got information from a medical oncologist saying:

    “P 53 is a tumor suppressor gene. If it is mutated it can be involved in carcinogenesis of many solid cancers, not only breast cancer. If it is highly expressed in breast cancer, it is associated with poor prognosis, even in hormone receptor positive disease.”

     I hope this could be the answer to your question.

    Best Usha

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  • Charz
    Charz Member Posts: 48
    edited May 2013

    Thanks Slousha, i wonder what "highly expressed" means... how much is high?

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  • slousha
    slousha Member Posts: 312
    edited May 2013

    Hi Charz,

    Can't answer this moment, try http://en.wikipedia.org/wiki/P53

    Best Usha

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  • netty46
    netty46 Member Posts: 296
    edited May 2013

    It sounds like it's a tumor supressor but I heard not in the case of breast cancer. Don't know how true that is. I did hearv if you have the p53 with p63 that's good.

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