Vitamins/Supplements during chemo???

Options

My naturopath gave me a list of supplements to take during chemo (and I have a bunch I already take). I brought the list to my onc and he kind of just shrugged at me -- apparently he thinks supplements are useless or something. I want to take some things to help with side effects and stuff but all the research I'm finding is SOOO controversial, like XYZ will increase the effectiveness of chemo but then another study says it does the opposite! I'm not sure what to do, I had hoped for at least a little guidance from my onc. I feel like I'm totally on my own and afraid I'll screw up. I'm starting treatment in just a few days. Part of me thinks I should err on the side of taking nothing, to ensure chemo works exactly as intended, but the other part of me is terrified of long-term side effects that could easily have been prevented or mitigated with supplements.

Comments

  • LtotheK
    LtotheK Member Posts: 2,095
    edited April 2013

    You are quite right to wonder. Your oncologist shouldn't be worried about supplements being useless, quite the opposite.

    Studies indicate a lot of things about supplements and naturopathic interventions during chemo, some good, some bad.  Some antioxidants, for instance, are believed to protect both good and bad cells.  Other supplements may block the efficacy of chemotherapy.

    The problem is, there will never be enough studies to definitively state all the effects. There are just too many supplements, for starters!  I made the decision to focus on the ones I felt had the most track record.  I used l-glutamine, and I did indeed avoid neuropathy.  Luck?  Hard to say.  The studies also indicate it, too may block some of the power of chemo.  I actually avoided almost all supplements during chemo active treatment.  My naturopathic intervention during chemo was diet (very high protein) and l-glutamine with focus on good foods.  When I finished chemo, I did a variety of cleanses and shifted my focus to supplements I thought worth considering.  I'm pretty spare--one doctor told me to only take US RDA of any supplement as other amounts may block the Tamoxifen I am on.  Again, never will be enough studies.  I stick to D, fish oil, calcium (for my sad post-chemo bones) and probiotics when I remember.

    Is there a possibility to work with a naturopath affiliated with your hospital?  That is what I did, and it was much easier to get cross flow of information.  I had to seek all this out myself, but I did find the balance of the two, with some even headedness on my part, was very helpful.

  • indenial
    indenial Member Posts: 504
    edited April 2013

    I don't think there are any naturopaths affiliated with my hospital. In fact, I think there are only 3 naturopaths in my whole state, and I've seen (and stopped seeing) all 3 at various points over the last couple years. The naturopath I see now is also my primary care doc and he missed my BC diagnosis (6 months earlier he brushed it off as "probably a cyst" and didn't even send me for tests or anything!) so I'm having a hard time trusting him at all. 

    I am thinking I want to do the l-glutamine because there is enough support for that and even my nurse recommended it. I'm not sure about regular vitamins, I may take them on an as-needed basis. I know I want to avoid Vit C & E in particular from what I've read. I'm worried about effects on the liver & was excited about milk thistle but then I realized the liver is one of the first places for mets so I don't want the chemo cleared out of there too quickly! So maybe that will be one to try AFTER I'm done with chemo, to repair the damage... Melatonin was recommended & seems to have some scientific backing (for both improving sleep & increasing survival substantially) but the dose studied is 20mg for some reason!! Usually 5mg is considered a high dose, I'm not sure I want to be taking 4 times that, and then I read something about it increasing estrogen, and it also seemed like most of the studies focused on patients with mets. 

    Really I just feel a bit helpless & out of control and want to DO SOMETHING to protect my body. At the same time, I am realizing years & years of eating clean, healthy, organic foods with carefully chosen supplements still didn't prevent me from getting BC so maybe I just need to chill out & let the chemo do it's thing. This is scary.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited April 2013

    Here's a study from Sloan Ketterling that claims L-glutamine is helpful during chemo...nothing about reducing effectiveness. In fact, I remember reading (when I was doing my own research) that glutamine can make cells more receptive to chemo...it was a study, not just a website, but I can't remember where I found it.

    http://www.mskcc.org/cancer-care/herb/glutamine

  • Anonymous
    Anonymous Member Posts: 1,376
    edited April 2013

    This may be somewhat off-topic but here is a link to fasting and cancer. http://www.economist.com/blogs/babbage/2012/02/fasting-and-cancer

    I know, the study was done on mice, but if you google fasting and longevity you'll find a lot of promising research regarding periodic fasting and humans.

  • indenial
    indenial Member Posts: 504
    edited April 2013

    I am so intrigued by the fasting studies! Unfortunately I can't try it becaues I used to be anorexic & it would be triggering for me. I wonder why my naturopath didn't recommend it though? He gave me a paper that specifically said keep calories up during treatment. Why can't all the docs & researchers get on the same page & give consistent advice??? LOL sorry I am just annoyed at the incongruities!! TY for the glutamine link, very reassuring!

  • SpecialK
    SpecialK Member Posts: 16,486
    edited April 2013

    I took 30g of L-Glutamine, 1500 mg of Acetyl L-Carnitine and a cap of B-6, all in the hopes of combatting neuropathy and cognitive dysfunction, and all with the blessing of my onc.  That was all I took during chemo though.  I did have mild neuropathy that resolved between treatments until the 5th one when it stayed in the bottoms of my feet, then it gradually dissipated over the few months after I completed chemo.  I have continued with the Acetyl L-Carnitine to support brain health, but lessened the dose to 500mg.  I did not take any antioxidant vitamins during chemo, but now take the RDA, along with a number of other supplements.  I did try to keep my protein intake as high as possible to support my hemoglobin and repair tissues being damaged by chemo, and to help heal from the multiple surgeries I had prior to starting.

  • LtotheK
    LtotheK Member Posts: 2,095
    edited April 2013

    Claire, that is AWESOME news about the l-glutamine!  I am really happy about that.  I will try to dig up the research I read otherwise, but I want to believe this one. indenial, I understand exactly how you feel.  It is so difficult when we feel like we already did everything right, and we want some control. You might try to incorporate some positive reinforcement through self talk to switch your fear to positive thoughts.  Sometimes, these "mantras" will come naturally. One that came to me was, "I have everything I need."  It helped me stop being frantic about research and the unknown.

    Sleep, water, exercise, l-glutamine, and high protein will do a lot to get you through treatment.  Maybe you don't need more than that for now, and then you can think about the others when you need to heal.

  • LtotheK
    LtotheK Member Posts: 2,095
    edited April 2013

    Claire, do you incorporate fasting into your regimen?  If so, would you share your method?  I've heard a lot of good stuff about it for weight loss, hormone management, and other things, too.

  • LtotheK
    LtotheK Member Posts: 2,095
    edited April 2013

    This covers some of the concerns about l-glutamine.  It can fuel tumor cell growth.  The in-vivo animal study data showed this not to be the case.  But as we know, animal studies are not human studies, or clinical trials. http://www.nhiondemand.com/viewcontent.aspx?mgid=519

    Anyway, I'm sticking with Sloan on this one!

  • Anonymous
    Anonymous Member Posts: 1,376
    edited April 2013

    LtotheK, I do a modified fast from time to time. I did fast 48 hours before chem and the day of, at least for ACDD. I tried to do it for taxol, too...but they were modified fasts (600 calories or less).

    Right now I'm starting the alternate day fast (one day fast, one day feed) which is supposed to be beneficial for health and weight loss.  The Univ of Chicago has done a lot of research on it....here's a link

    http://www.ahs.uic.edu/news/title,10771,en.html

    This is just a news article, but if you watch the PBS special named above you'll find the specific research support about alternate day fasting.

    http://www.dailymail.co.uk/health/article-1230347/Feast-famine-The-diet-wont-just-help-lose-weight-youll-live-longer-brainier.html

  • Denise-G
    Denise-G Member Posts: 1,777
    edited April 2013

    At the Univ of Michigan, they warned me not to take alot of supplements without permission - even juicing - as it can interfere with Chemo.  One of my Nurse Practitioners had her doctorate in Alternative Medicines and she warned me about it.  She said juicing can be so effective, it will fight Chemo. 

    Vitamin B was allowed...and I remember the Rad Onc saying not to take a bunch of supplements during Radiation either.  The minute I was done, I got the go ahead.

  • indenial
    indenial Member Posts: 504
    edited April 2013

    OK. Thank you all for your input and for calming me down! I think I have decided to go minimal on the supplements. I may take my cal/mag if my teeth grinding acts up, maybe give myself a B-complex injection if needed, maybe some vitamin D in half-doses in between treatments. Besides that, I guess I will just stick with the glutamine & let the chemo do it's thing and do some repair work once I'm finished. 

    And how on earth do you choke down the glutamine, by the way? I tried it today (in water) & it was gross. I'm supposed to do swish & swallow but not sure I can tolerate the taste if I get even a touch of nausea!

  • Anonymous
    Anonymous Member Posts: 1,376
    edited April 2013

    yep, the l-glutamine is kind of gross; some ladies put it in tea (I never had the time) or juice.  I just swallowed quickly and got on with my day! Good luck. I'll bet you do fine and we are all rooting for you!

    Smile

  • SpecialK
    SpecialK Member Posts: 16,486
    edited April 2013

    indenial - I dissolved the L-Gutamine powder, 10g 3 times a day, in tea.  I tried putting it in applesauce - NOT GOOD!  Tasted like chalk!

Categories