Anyone have a small grade 1 tumor that was node + ?

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  • kyliet
    kyliet Member Posts: 687
    edited March 2013

    My 3 positive nodes (not micro.) with extracap. extension didn't show up in original mammo and US. Nor did my satellite tumour. This makes me wary of trusting 'clear' mammo I just got. 

    Anyone else have this happen?

  • Runnergirl2013
    Runnergirl2013 Member Posts: 83
    edited March 2013

    My tumor was .6cm and was grade 1.....one of my nodes had a micromet of .15 cm. my tumor was too small that the oncotype came back inconclusive so the oncs recommended four rounds of TC chemo. I am just finishing rads and I just worry about it coming back. I had such a low chance to get cancer and got it. Then they told me I had such a low chance of lymph node involvement and got that,.....I now need to come to grips with moving forward. Hugs

  • nybc2013
    nybc2013 Member Posts: 13
    edited March 2013

    Hi, thank you for sharing this information. My IDC is .4 mm no nodes and grade 1.  Were your cells well differentiated as I am trying to understand 1B.  I am deciding between a quadrantectomy and a unilateral and  I too have been told that it won't come back.  Did you have a recurrence or was the node found at surgery?  

  • kira1234
    kira1234 Member Posts: 3,091
    edited March 2013

    Runnergirl2013, I'm surprised your onco test came back inconclusive. My tumor was also .6cm, and they had no trouble testing mine.  Icame back in the dreaded gray area at 24 which is a bummer to say the least, but at least I know!

  • Runnergirl2013
    Runnergirl2013 Member Posts: 83
    edited March 2013

    They ran the test two times each time the test came back inconclusive because the tumor was too small..... Such a bummer because I did do chemo I did four rounds of TC chemo

  • LW122713
    LW122713 Member Posts: 52
    edited April 2013

    My initial diagnosis was IDC stage 1 with 1.8 microcalcifications, nothing to feel, just cancer cells. The mammogram and Ultrasound showed no node involvement. My MO and surgeon said they didn't expect any surprises with the lumpectomy. The pathology showed 1 cm microcalcifications and a 4mm macromet in the sentinal node. I was upgraded to stage lla, grade ll. It was hard to swallow because all the original evidence and the professionals were indicated something much less invasive. We then went from only doing 33 rounds of radiation to now 6 rounds of chemo, plus the 33 rounds of radiation. I'm typing this while sporting my sleep cap that covers up my 90% bald head. It is really hard to wrap your head around how unpredictable this all can be.



    I hope you can all find peace with it. I'm still trying to find it!

  • gardengumby
    gardengumby Member Posts: 7,305
    edited April 2013

    My initial diagnosis was IDC stage 1 (slightly larger than 1cm).  Then they found DCIS (6 cm).  Then they found I had node involvement - moved to stage 2.  Then they found a second IDC - smaller than the first.  After the mastectomy (UMX) I finally got some good news that my oncotype was low (14).  The larger IDC was Grade 2, which was also the one they used for the oncotype testing.  I thought the smaller IDC was grade 3, but I haven't re-read my pathology report for a long time, so will have to re-read again one of these days.  In the meantime, I take my letrozole religiously and hope for goodt long term results.  Since there are no guarantees, though, I am retiring this year and moving on with more enjoyment of life.

  • kiwikid
    kiwikid Member Posts: 204
    edited April 2013

    Aussieched your stats are similar to mine. My micromet was .6mm, so tiny, and the tumor was 18mm. Both the biopsy of the tumor, and the actual tumor were tested, and both were grade 1 with mitotic counts of 1.

    My oncologist said my ki67 of 18% was unusual and indicated a propensity for travel.

    I worry about late recurrence, but I worry abut most things.

    Xx kk

  • kyliet
    kyliet Member Posts: 687
    edited April 2013

    kiwikid, thanks for that info. I had a ki67 of 20. I was told it was unusual with a grade 1, and not a good thing but I didn't understand why. 

  • kiwikid
    kiwikid Member Posts: 204
    edited April 2013

    Kyliet that's interesting. The radiation oncologist said that about 5% of low grade tumours have a high ki67. Maybe it's an age thing, how old are you?

    On the other hand, my second opinion medical oncologist said that a ki67 of 14% would have been the cut off an I wouldn't have been offered chemo if I was under that. He also said that the testing for it is unreliable and with a different lab tech on a different day I could've had a different number, so I don't know how much weight to put on it really

    Xx Kk

  • kyliet
    kyliet Member Posts: 687
    edited April 2013

    Kiwi - I am 45. My ki67 wasnt even mentioned till after chemo started but if you read my top line I had a few other issues other than the 3 nodes which factored in. 

    Sometimes I think they just don't know. I have been told by a few professionals that once it is in your lymph nodes the grade isn't very relevant any more. Not sure about that one.

  • lydiabest54
    lydiabest54 Member Posts: 18
    edited January 2014

    I know your post is almost 2 years old, but in your post you stated that your physician said that  because your tumor was so slow growing, you will need monitoring longer. You stated that you physician said that if you did get a recurrence, it would likely occur after 20 years? I had triple negative breast cancer wanted to know this.  Do slower growing tumors have a tendency to recur later?  The tumor i had was a grade 3 tumor and I was in stage 2.

  • kyliet
    kyliet Member Posts: 687
    edited February 2014

    Hi lydiabest, I am not sure about your situation but from what you are saying your tumour was grade 3 which is faster growing than my grade 1. There is a thread specifically for triple negative and I am sure some of the lovely women on there could answer some of your questions better than I can.  Hugs x

  • InspiredbyDolce
    InspiredbyDolce Member Posts: 1,181
    edited February 2014

    Lydiabest,

    I think it's hard to know what was inferred by a doctor's statement without knowing in what context he was speaking, etc.  So regarding the 20 years before a recurrence, I think it's just too ambiguous to know what that doctor meant.  Plus, if a bc occurs again after 20 years, I think it's called a new primary, not a recurrence.  

    Here is a link to the Mitotic Grading Scale and the information that goes into evaluating and grading each tumor to arrive at the Grade 1, 2 or 3 classification.  It's also worthy to note here as well that a Grade 1 tumor presents with node involvement or there is lymphatic invasion, then I believe they say that the tumor is acting aggressively -- and likewise a tumor that is Grade 3 and perhaps very large, like 5cm but not in the nodes or lymphatic system, would be acting less aggressively.

    So try to remember that the Grade is only one factor to estimate a patient's prognosis, it's one diagnostic tool and there are many tools by which the doctors use to assess and plan for our survivorship.

    http://pathology.jhu.edu/breast/grade.php

    From the link "The grade of a breast cancer is representative of the "aggressive potential" of the tumor; in a broad generalization, "low grade" cancers tend to be less aggressive than "high grade" cancers. Determining the grade is thus very important, and the clinicians use this information to help guide the treatment options for patients."

  • juneping
    juneping Member Posts: 1,594
    edited February 2014

    very interesting discussion. i think someone mentioned there're factors that cancer cells travel.

    it's the grade, proliferation. i don't think grade 1 means speed, it's more of the state, poorly differentiated or looked similar to normal cells. and speed is proliferation Ki67 %. i've been reading too many threads, and someone mentioned some cancer cells are just travelers and some are dwellers. 

    sometimes when i was so tired of reading the science of BC, i just felt it's all luck of the draw. some lady mentioned her mom had a MX without any TX and never had a recurrent for 25+ years. and someone went thru all the TX available and still got a recurrence. cancer sucks!!

  • edwards750
    edwards750 Member Posts: 3,761
    edited February 2014

    bahamamom...I am one of those people with a Grade 1 tumor and a micromet in the SN. I was staged at Stage 1 before my lumpectomy but the Path report after surgery showed a micromet in the SN. My BS was surprised; I was shocked. I asked my Oncologist why they didnt take out more nodes and she said because they didnt believe other nodes were affected because of the small size. She reassured me if they believed there was more node involvement they would have removed more nodes. My BS said they had to dissect and dissect again to find it and it would probably mean chemo. It didn't. My Oncologist ordered the Oncotype test and my score came back@11 with an 8% chance of recurrence following 33 RADS treatments and at least 5 years on Tamoxifen. The micromet was so small...thus micro...that it was labeled as node negative. My understanding is the lower the grade the better. We all know this is a crapshoot no matter what our stats are and no guarantees. More often than not lower stage tumors and grade levels enhance your chances of it not coming back but we all know the medical community isn't infalliable nor are the tests. Good luck. Diane

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